A5088378966- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Glaucoma and retinal disorders
- Retinal and Optic Conditions
- Plasma Applications and Diagnostics
- Studies on Chitinases and Chitosanases
- HER2/EGFR in Cancer Research
- Blood Pressure and Hypertension Studies
- Ophthalmology and Visual Impairment Studies
- Estrogen and related hormone effects
- Cerebrovascular and Carotid Artery Diseases
- Optical Coherence Tomography Applications
- Lung Cancer Diagnosis and Treatment
- RNA modifications and cancer
- Peptidase Inhibition and Analysis
- Lung Cancer Research Studies
- Inflammatory mediators and NSAID effects
- Lung Cancer Treatments and Mutations
- Electrohydrodynamics and Fluid Dynamics
- Traditional Chinese Medicine Studies
- Ophthalmology and Visual Health Research
- Frailty in Older Adults
- Atherosclerosis and Cardiovascular Diseases
- Ferroptosis and cancer prognosis
- Acute Kidney Injury Research
Moorfields Eye Hospital NHS Foundation Trust
2022-2025
University College London
2022-2025
National Health Service
2024
National Institute for Health Research
2024
Xi'an Jiaotong University
2008-2024
Chongqing Medical University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2024
Moorfields Eye Hospital
2024
Hanzhong Central Hospital
2024
Columbia College
2024
Abstract Medical artificial intelligence (AI) offers great potential for recognizing signs of health conditions in retinal images and expediting the diagnosis eye diseases systemic disorders 1 . However, development AI models requires substantial annotation are usually task-specific with limited generalizability to different clinical applications 2 Here, we present RETFound, a foundation model that learns generalizable representations from unlabelled provides basis label-efficient adaptation...
Cadaveric studies have shown disease-related neurodegeneration and other morphological abnormalities in the retina of individuals with Parkinson disease (PD); however, it remains unclear whether this can be reliably detected vivo imaging. We investigated inner retinal anatomy, measured using optical coherence tomography (OCT), prevalent PD subsequently assessed association these markers development a prospective research cohort.
To test clinically relevant factors associated with quantitative artifact-free deep capillary plexus (DCP) metrics in patients diabetes mellitus (DM).563 eligible eyes (221 no diabetic retinopathy [DR], 135 mild DR, 130 moderate and 77 severe DR) from 334 subjects underwent optical coherence tomography-angiography (OCT-A) a swept-source OCT (Triton DRI-OCT, Topcon, Inc., Tokyo, Japan). Strict criteria were applied to exclude analysis those DCP images artifacts of poor quality, including...
Purpose To examine the association of physical activity (PA) with glaucoma and related traits; to assess whether genetic predisposition modified these associations; probe causal relationships using Mendelian randomization (MR). Participants UK Biobank participants data on self-reported or accelerometer-derived PA intraocular pressure (IOP) (N=94 206 N=27 777, respectively); macular inner retinal optical coherence tomography (OCT) measures (N = 36 274; N=9 991); status (N= 86 803; N=23 556)....
Better understanding of primary open-angle glaucoma (POAG) genetics could enable timely screening and promote individualized disease risk prognostication.
Purpose: Smoking may influence measured IOP through an effect on corneal biomechanics, but it is unclear whether this factor translates into increased risk for glaucoma. This study aimed to examine the association of cigarette smoking with biomechanical properties and glaucoma-related traits, probe potential causal effects using Mendelian randomization (MR). Methods: Cross-sectional analyses within UK Biobank (UKB) Canadian Longitudinal Study Aging (CLSA) cohorts. Multivariable linear...
Abstract Background Sensory changes due to aging or disease can impact brain tissue. This study aims investigate the link between glaucoma, a leading cause of blindness, and alterations in connections. Methods We analyzed diffusion MRI measurements white matter tissue large group, consisting 905 glaucoma patients (aged 49-80) 5292 healthy individuals 45-80) from UK Biobank. Confounds group differences were mitigated by matching sub-sample controls subjects. compared classification using...
Increasing evidence has indicated that the splicing factor hnRNPA2B1 plays a direct role in cancer development, progression, gene expression, and signal transduction. Previous studies have shown knocking down breast cells induces apoptosis, but mechanism other functions of are unknown. The goal this study was to investigate biological function, clinical significance, cancer. expression 92 adjacent normal tissue pairs analyzed by immunohistochemical staining. Stable clones exhibiting...
To examine the associations of alcohol consumption with glaucoma and related traits, to assess whether a genetic predisposition modified these associations, perform Mendelian randomization (MR) experiments probe causal effects. Cross-sectional observational gene–environment interaction analyses in UK Biobank. Two-sample MR using summary statistics from large consortia. Biobank participants data on intraocular pressure (IOP) (n = 109 097), OCT-derived macular inner retinal layer thickness...
Abstract Few metrics exist to describe phenotypic diversity within ophthalmic imaging datasets, with researchers often using ethnicity as a surrogate marker for biological variability. We derived continuous, measured metric, the retinal pigment score (RPS), that quantifies degree of pigmentation from colour fundus photograph eye. RPS was validated two large epidemiological studies demographic and genetic data (UK Biobank EPIC-Norfolk Study) reproduced in Tanzanian, an Australian, Chinese...
Aberrant epigenetic and transcriptional events that drive cancer progression could be precisely targeted. We aimed to uncover the roles of RBBP7 on breast (BCa) stemness metastasis. The bioinformatic analysis was used assess clinical significance in BCa. CCK8, colony formation, Transwell assays were utilized estimate oncogenic functions RBBP7. ChIP-qPCR dual-luciferase reporter investigate mechanisms Tumor sphere formation conducted self-renewal abilities BCa cells. Tail vein injection...
Background Lower respiratory infections (LRI), caused by various pathogens, have significant impacts on global health. Air pollution is a major environmental factor in the development of LRI, and with ongoing urbanization industrialization, it has become critical public health concern. The older adult population, declining immune function physiological capabilities, exhibits reduced resistance to air pollution, making them high-risk group for LRI. However, spatiotemporal trends LRI burden...
This study aims to describe the grading methods and baseline characteristics for UK Biobank (UKBB) participants who underwent retinal imaging in 2009-2010, characterise individuals with features suggestive of age-related macular degeneration (AMD), glaucoma retinopathy.Non-mydriatic colour fundus photographs optical coherence tomography (OCT) scans were manually graded by Central Administrative Research Facility certified graders quality assured clinicians Network Ophthalmic Reading Centres...
Due to the extremely high bond energy of N≡N (∼941 kJ/mol), traditional Haber–Bosch process ammonia synthesis is known as an energy-intensive and CO2-emission industry. In this paper, a cascade N2 reduction with dielectric barrier discharge (DBD) plasma oxidation electrocatalytic alternative route first proposed. oxidized be reactive nitrogen species (RNS) by nonthermal plasma, which would then absorbed KOH solution electroreduced NH4+. It found that production NOx function length, power,...
Background/aims To determine whether a combination of baseline and change in spectral domain-optical coherence tomography (SD-OCT)-based biomarkers can predict visual outcomes eyes with diabetic macular oedema (DMO) treated antivascular endothelial growth factors (VEGF) injections. Methods This is retrospective cohort study conducted Hong Kong, China. 196 centre-involving DMO, who received anti-VEGF injections between 1 January 2011 30 June 2018 were recruited. Medical records the...
To identify residents' perceived barriers to learning phacoemulsification surgical procedures and evaluate whether virtual reality simulation training changed these perceptions.The ophthalmology residents undertook a course proficiency assessment on the Eyesi system using previously validated modules of intracapsular navigation, anti-tremor, capsulorrhexis, cracking/chopping. A cross-sectional, multicenter survey difficulties in performing tasks patients, based International Council...
<h3>Importance</h3> Understanding the effects of modifiable risk factors on for multiple sclerosis (MS) and associated neurodegeneration is important to guide clinical counseling. <h3>Objective</h3> To investigate associations alcohol use, smoking, obesity with odds MS diagnosis macular ganglion cell layer inner plexiform (mGCIPL) thickness. <h3>Design, Setting, Participants</h3> This cross-sectional study analyzed data from community-based UK Biobank health behaviors retinal thickness...
Abstract Background and purpose The eye is a well‐established model of brain structure function, yet region‐specific structural correlations between the retina remain underexplored. Therefore, we aim to explore describe relationships retinal layer thicknesses magnetic resonance image (MRI)‐derived phenotypes in UK Biobank. Methods Participants with both quality‐controlled optical coherence tomography (OCT) MRI were included this study. Retinal sublayer total macular thickness derived from...
Aim To examine the correlation of best-corrected visual acuity (BCVA) with intercapillary area (ICA) measured from optical coherence tomography angiography (OCT-A) in patients diabetes, and to compare strength associations between BCVA ICA other OCT-A metrics. Methods A cross-sectional study involved 447 eyes 299 diabetes. All participants underwent a swept-source OCT (Triton DRI-OCT, Topcon, Tokyo, Japan). An automated customised MATLAB programme was used quantify (the mean 10 largest areas...
PurposeTo examine the association of baseline choroidal sublayers metrics with risk diabetic retinopathy (DR) progression over 2 years, adjustment for confounding factors that affect measurements.DesignProspective, observational cohort study.ParticipantsOne hundred three eyes from 62 patients diabetes mellitus (DM).MethodsPatients were followed up at 6-month intervals least years. Choroidal including area, thickness (CT), and vascularity index measured both (1) choriocapillaris plus...