A5101644213- Retinal Imaging and Analysis
- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Noise Effects and Management
- Vehicle Noise and Vibration Control
- Aortic aneurysm repair treatments
- Respiratory Support and Mechanisms
- Aortic Disease and Treatment Approaches
- Cardiac, Anesthesia and Surgical Outcomes
- S100 Proteins and Annexins
- Trauma Management and Diagnosis
- Mesenchymal stem cell research
- Cardiac Structural Anomalies and Repair
- Hedgehog Signaling Pathway Studies
- Glycosylation and Glycoproteins Research
- Trauma and Emergency Care Studies
- Oral microbiology and periodontitis research
- Cardiac Valve Diseases and Treatments
- Sirtuins and Resveratrol in Medicine
- Nonmelanoma Skin Cancer Studies
- Protease and Inhibitor Mechanisms
- Acute Ischemic Stroke Management
- Periodontal Regeneration and Treatments
- Medical and Biological Ozone Research
- Pain Mechanisms and Treatments
Nanjing Drum Tower Hospital
2023-2025
Affiliated Hospital of Nantong University
2023-2024
Nantong University
2023-2024
Second Affiliated Hospital of Nantong University
2024
Nanjing Jiangning Hospital
2023
Nanjing Medical University
2023
University of Hong Kong
2023
Nanjing University
2023
Chinese University of Hong Kong
2021-2022
Air Force Medical University
2004-2007
Abstract Cutaneous squamous cell carcinoma (cSCC) is a malignant tumor originating from epidermal or appendageal keratinocytes, with rising incidence in recent years. Understanding the molecular mechanism driving its development crucial. This study aims to investigate whether miR-34a-5p involved pathogenesis of cSCC by targeting Sirtuin 6 (SIRT6).The expression levels and SIRT6 were determined 15 tissue specimens, normal specimens cultured cells via real-time polymerase chain reaction...
Abstract Aims Methyltransferase like 3 (METTL3) plays a crucial role in cardiovascular diseases, but its involvement atrial fibrillation (AF) remains unclear. The study aims to explore the relationship between METTL3 and AF myocytes. Methods results protein level of was evaluated left appendages (LAAs) from patients with persistent experimental models. cAMP-responsive element modulator (CREM) transgenic mice CaCl2-acetylcholine (ACh)-injected were used as globally conditionally deleted vivo...
Cranial neural crest-derived ectomesenchymal cells may be pluripotent stem that are capable of generating a range phenotypes. The fate these appears to determined in part by intrinsic genetic programs and also the influence extracellular signals local environment. extent lineage determination once crest have migrated first branchial arch is not clear, although pattern thought result predetermination. aim present study was test hypothesis show properties cells, which directed specific...
PurposeTo examine the association of baseline choroidal sublayers metrics with risk diabetic retinopathy (DR) progression over 2 years, adjustment for confounding factors that affect measurements.DesignProspective, observational cohort study.ParticipantsOne hundred three eyes from 62 patients diabetes mellitus (DM).MethodsPatients were followed up at 6-month intervals least years. Choroidal including area, thickness (CT), and vascularity index measured both (1) choriocapillaris plus...
Abstract Purpose To investigate the features of small‐to‐medium (choriocapillaris and Sattler’s layer) large (Haller’s sized vessel layers macular choroid in normal‐tension glaucoma (NTG) patients using swept‐source optical coherence tomography (SS‐OCT). Methods We conducted an observational cross‐sectional study 234 NTG eyes from 134 patients, 203 normal 109 non‐glaucomatous control subjects. used Image J to segment choroidal layer then a Python script measure average thickness (MCT)...
Purpose: Artificial intelligence (AI) deep learning (DL) has been shown to have significant potential for eye disease detection and screening on retinal photographs in different clinical settings, particular primary care. However, an automated pre-diagnosis image assessment is essential streamline the application of developed AI-DL algorithms. In this study, we validated a DL-based module photographs, targeting quality (gradable vs. ungradable), field view (macula-centered...
Purpose: We aimed to develop and test a deep-learning system perform image quality diabetic macular ischemia (DMI) assessment on optical coherence tomography angiography (OCTA) images. Methods: This study included 7,194 OCTA images with diabetes mellitus for training primary validation 960 from three independent data sets external testing. A trinary classification the presence or absence of DMI were labeled all Two DenseNet-161 models built both tasks superficial deep capillary plexuses,...
To establish models for predicting descending thoracic aortic diameters and provide evidence selecting the size of stent graft TBAD patients.A total 200 candidates without severe deformation aorta were included. CTA information was collected 3D reconstructed. In reconstructed CTA, a 12 cross-sections peripheral vessels made perpendicular to axis flow aorta. Parameters cross sections basic clinical characteristics used prediction. The data randomly split into training set test in an 8:2...
Introduction: In proliferative diabetic retinopathy (PDR), retinal neovascularization is the essential pathogenic process that linked to endothelial-to-mesenchymal transition (EndoMT) induced by high glucose (HG). This pathophysiological may be regulated a G-protein-coupled chemoattractant receptor FPR2 (mouse Fpr2), involved in inflammatory cell migration and proliferation. current study, we investigated role of Fpr2 regulating EndoMT underlying mechanisms during progression. Methods:...
Prior studies on the association between traffic noise and mental health have been mostly conducted in low-density settings. However, evidence is lacking high-density settings where more pervasive varies by topography vertical elevation of residential unit. This study aimed to assess impact one world’s most urbanised populations. Data were analysed from 13,401 participants aged ≥15 years a prospective cohort Hong Kong 2009 2014. Residential level was estimated using 3D-geocoding validated...
体液过载相关大B细胞淋巴瘤是第5版WHO造血与淋巴组织肿瘤分类中大B细胞淋巴瘤一种新的亚型。该肿瘤老年人多见，发生于体腔与体液过载相关，缺乏淋巴结受累和结外占位性病变以及潜在免疫缺陷，且预后较好；是不同于原发性渗出性淋巴瘤的一类独立病变实体。本文报道1例该类典型病例，观察其临床病理特征及分子改变，并复习相关文献，旨在加深对此类新分类淋巴瘤的认识，避免误诊。.
Objective. This study aimed to determine the risk factors of new-onset postoperative atrial fibrillation after ascending aortic replacement in acute type A dissection patients, with emphasis on biochemical parameters. Methods. From Jan 2020 Dec 2021, a total 435 patients who underwent and without history were retrospectively analyzed this study. Perioperative data these obtained from hospital’s database. The 30-day follow-up was via telephone interviews. multivariate regression analysis used...
Introduction: Coronary microcirculation dysfunction (CMD) is recognized as a pivotal pathophysiological change of coronary artery disease (CAD) with diabetes, however, there little evidence for CMD medication treatment. Though enhanced external counterpulsation (EECP), non-invasive therapy to increase shear stress flow, has been proved release angina and restore endothelial capacities, whether EECP could attenuate remains unknown. Hypothesis: in patients CAD diabetes. Methods: This single...