A5046355810- Dermatologic Treatments and Research
- Autoimmune Bullous Skin Diseases
- Hair Growth and Disorders
- Eosinophilic Esophagitis
- Dermatology and Skin Diseases
- Dermatological and Skeletal Disorders
- Retinal Diseases and Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Computational Drug Discovery Methods
- Immunotherapy and Immune Responses
- Retinal Imaging and Analysis
- Contact Dermatitis and Allergies
- T-cell and B-cell Immunology
- Asthma and respiratory diseases
- Social Media in Health Education
- Mathematics, Computing, and Information Processing
- Microscopic Colitis
- Cutaneous lymphoproliferative disorders research
- Skin Protection and Aging
- T-cell and Retrovirus Studies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Autoimmune and Inflammatory Disorders
- Health Literacy and Information Accessibility
- Animal testing and alternatives
- Gene Regulatory Network Analysis
King's College London
2018-2025
Guy's and St Thomas' NHS Foundation Trust
2020-2025
University of Houston
2025
St Thomas' Hospital
2017-2024
University of Southampton
2013-2017
University Hospital Southampton NHS Foundation Trust
2014
Southampton General Hospital
2013
Imperial College London
2010-2011
National University of Singapore
2006-2007
Keloids and hypertrophic scars (excessive scarring) are relatively understudied disfiguring chronic skin conditions with high treatment resistance.
Frontal fibrosing alopecia (FFA) is an increasingly prevalent form of follicular lichen planus, causing irreversible hair loss predominantly in postmenopausal individuals. An earlier genome-wide meta-analysis female FFA identified risk loci genes implicated self-antigen presentation and T-cell homeostasis, including HLA-B*07:02, ST3GAL1, SEMA4B. However, CYP1B1, which important for hormone metabolism, was also with the substitution serine asparagine at position 453 (c.1358A>G, p.Asn453Ser)...
Abstract Few metrics exist to describe phenotypic diversity within ophthalmic imaging datasets, with researchers often using ethnicity as a surrogate marker for biological variability. We derived continuous, measured metric, the retinal pigment score (RPS), that quantifies degree of pigmentation from colour fundus photograph eye. RPS was validated two large epidemiological studies demographic and genetic data (UK Biobank EPIC-Norfolk Study) reproduced in Tanzanian, an Australian, Chinese...
Fragrance contact allergy is common and currently screened for using the following European baseline series fragrance markers: mix (FM)I, FMII, Myroxylon pereirae hydroxyisohexyl 3-cyclohexene carboxaldehyde.To investigate validity of patch testing these markers in detecting to 26 individual substances which cosmetic ingredient labelling mandatory within Union.We conducted a retrospective review test records all patients with eczema who underwent series, extended during period from 2015...
Langerhans cells (LCs) are able to orchestrate adaptive immune responses in the skin by interpreting microenvironmental context which they encounter foreign substances, but regulatory basis for this has not been established. Utilising systems immunology approaches combining silico modelling of a reconstructed gene network (GRN) with vitro validation predictions, we sought determine mechanisms regulation human primary LCs. The key role Interferon factors (IRFs) as controllers cell response...
Abstract Background Few metrics exist to describe phenotypic diversity within ophthalmic imaging datasets, with researchers often using ethnicity as an inappropriate marker for biological variability. Methods We derived a continuous, measured metric, the retinal pigment score (RPS), that quantifies degree of pigmentation from colour fundus photograph eye. RPS was validated two large epidemiological studies demographic and genetic data (UK Biobank EPIC-Norfolk Study). Findings A genome-wide...
Primary cutaneous nodular amyloidosis (PCNA) presents as solitary or multiple firm, waxy nodules with a predilection for acral areas. Histologically, PCNA can be identical to myeloma-associated systemic monoclonal immunoglobulin light chain deposits. We describe patient in whom developed scar an area affected by chronic plaque psoriasis. has previously been associated other autoimmune diseases, but our knowledge, this is the first association Interestingly, T helper (Th)17 cells, which are...
<h3>Introduction</h3> The normal count for intraepithelial lymphocytes (IELs)/100 enterocytes in the colon has been defined at 20. Normal eosinophil counts are harder to identify. In caecum, eosinophils more numerous and up 40/high power fields (HPF) is suggested be normal. Irritable Bowel Syndrome (IBS), by definition not associated with pathology microscopy but colonic innate immune disorder implicated some patients. aim of this study was define cell a group subjects compare these IBS...