Pseudomyxoma peritonei (PMP) is a complex disease with unique biological behavior that usually arises from appendiceal mucinous neoplasia. The classification of PMP and its primary neoplasia contentious, an international modified Delphi consensus process was instigated to address terminology definitions. A developed, it agreed "mucinous adenocarcinoma" should be reserved for lesions infiltrative invasion. term "low-grade neoplasm" supported "cystadenoma" no longer recommended. new...

Gastrointestinal stromal tumor or smooth muscle (GIST) is the designation for a major subset of gastrointestinal mesenchymal tumors that histologically, immunohistochemically, and genetically differ from typical leiomyomas, leiomyosarcomas, schwannomas. Because GISTs, like interstitial cells Cajal, pacemaker cells, express CD117 (c-kit protein), origin GISTs Cajal has been recently proposed. Comparison primary in omentum mesentery to tubular tract particular diagnostic histogenetic interest...

We reviewed 84 cases coded as mesenteric lipodystrophy (ML), panniculitis (MP), or retractile mesenteritis and sclerosing (SM), grading fibrosis, inflammation, fat necrosis, evaluating clinical subgroups. There was no gender racial predominance. Patient age range 23-87 years (average 60). Patients most often presented with abdominal pain a palpable mass. A history of trauma surgery present in four patients. The common site involvement the small bowel mesentery single mass (58 84) an average...

Background. The current understanding of appendiceal epithelial tumors is based on series composed relatively small numbers patients and case reports. aim this study was to perform clinicopathologic correlation, particularly concerning prognosis, a large with tumor-like lesions the human vermiform appendix. Methods. One hundred eighty-four cases simple mucoceles, hyperplastic polyps, adenomas, carcinomas, mucinous uncertain malignant potential (UMP) were reviewed. Retrospective follow-up...

Aims: To determine the prevalence of colorectal polyps different types in an unselected population, and to correlate morphological diagnoses with BRAF mutation analysis. Methods: Cases diagnosed at endoscopy were retrieved from files Southern.IML Pathology. All slides reviewed lesions classified histologically. A diagnosis sessile serrated adenoma was made even if characteristic features present only focally. If there more than one polyp a particular type any patient, lesion chosen random so...

Abstract Background : Multimodal therapeutic strategies have improved the outcome of peritoneal metastases (PM). However, objective assessment therapy response remains difficult in PM, since radiological studies a poor accuracy for low-volumetric disease. There is an obvious need histological gold standard allowing tumor to treatment PM. Content We propose perform punch biopsies with diameter 3 5 mm all four abdominal quadrants. four-tier Peritoneal Regression Grading Score (PRGS), defined...

Colorectal cancer peritoneal metastasis (CPM) confers an exceptionally poor prognosis, and traditional treatment involving systemic chemotherapy (SC) is largely ineffective. Cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal (HIPEC) increasingly advocated for selected patients CPM; however, opinions are divided because of the perceived lack evidence, high morbidity, mortality, associated costs this approach. As there no clear consensus, aim study was to compare outcomes...

Calcification and fibrosis in mesenteric carcinoid tumor: CT findings pathologic correlation.L Pantongrag-Brown, P C Buetow, N J Carr, E Lichtenstein L BuckAudio Available | Share

To determine the effect of pathological severity cirrhosis on survival in patients with alcohol-related cirrhosis.Liver biopsies from 100 were scored for Laennec score cirrhosis, and medical notes reviewed to various clinical factors, including drinking status. Up-to-date mortality data obtained using National Health Service Strategic Tracing Service.Southampton General Hospital between 1 January 1995 31 December 2000.A total consecutive biopsy proven alcohol-induced liver cirrhosis.Laennec...

Aims The four‐tiered peritoneal regression grading score ( PRGS ) assesses the response to chemotherapy in metastasis PM ). is used, for example, assess pressurised intraperitoneal aerosol PIPAC However, reproducibility of currently unknown. We aimed evaluate inter‐ and intraobserver variability . Methods results Thirty‐three patients who underwent at least three treatments as part ‐ OPC 1 or 2 clinical trials Odense University Hospital, Denmark, were included. Prior each therapy cycle,...

The aim of this study was to explore whether CD34 immunoreactivity can distinguish between different types gastrointestinal stromal tumour, i.e. smooth muscle and neurogenic. We studied 87 tumours from sites in the tract, as well omentum mesentery, using a monoclonal antibody (QBEND10). also determined immunoexpression specific actins, S-100 protein, cytokeratin, desmin vimentin. In addition, 15 cases mesenteric fibromatosis were tested for CD34. Immunoexpression observed 40 correlated with...

The differential expression of cytokeratin (CK) 7 and 20 by carcinomas may help in determining the primary site a metastatic tumour. aim this study was to extend published data on CK7 CK20 epithelial neoplasms gastrointestinal tract considering degree differentiation including some unusual neoplasms.Cases referred Armed Forces Institute Pathology were studied prospectively for immunohistochemical CK20. Lesions from 105 patients analysed. Adenocarcinomas upper positive both 78% cases; only...

Pelvic multivisceral resection offers the possibility of cure in patients with locally advanced rectal cancer. This study assessed clinical outcome and determinants survival local recurrence undergoing for T4 primary cancer.This was a cohort consecutive resections carried out single centre from 2000 to 2009. Determinants were examined by means Kaplan-Meier curves Cox regression analysis.The included 42 patients, median age 62 (range 41-83) years, who underwent surgery follow-up 30 2-102)...

This study presents a detailed histological analysis of two cases splenosis, including one the largest nodules to be reported. Splenosis may exhibit red and white pulp that appears histologically immunohistochemically normal by routine methods, well‐developed capsule trabeculae form. The thicker than in spleen but is otherwise indistinguishable contain fibrous, elastic smooth muscle elements. These findings are contrast previously published works which have described poorly‐developed pulp,...

Due to increased cognitive and social congruence with their tutees, near peer teachers (NPTs) may be capable of more effectively delivering course material. This study examines NPTs as pathology tutors alongside traditional (e.g., consultants registrars) explore acceptability, effectiveness, years 'distance' between tutees.In total, 240 first- second-year undergraduate medical students were taught set material in a tutorial setting by (fourth-year students), registrars, or consultants....

Abstract Context.—Carcinomas of the appendix are usually well-differentiated mucinous adenocarcinomas that tend to produce pseudomyxoma peritonei and do not show metastatic spread until late in disease process. In contrast, colon rectum rarely result frequently metastasize, even if well differentiated. These differences behavior may be reflected by at molecular level. Objectives.—To examine their precursor lesions (adenomas) colorectum determine whether exist numbers proliferating apoptotic...

A multicenter retrospective review of cases diagnosed as spirochetosis was performed to determine the presenting symptoms and histological changes. total 113 were retrieved from archives, consisting 97 colorectal specimens 16 appendices. In only 25 symptom recorded diarrhea. Of specimens, 87 (90%) showed no mucosal abnormality (apart spirochetes); other 10 inflammation but 6 them had a diagnosis another inflammatory disease process accounting for Five appendices acute appendicitis; 11...

To investigate the association of serum levels proangiogenic cytokines with different indices social support and loneliness by measuring expression two important cytokines, vascular endothelial growth factor (VEGF), interleukin-6 in tumors colon rectum. Lack has been prospectively associated cancer progression.Fifty-one newly diagnosed patients colorectal (mean age, 68.3 years) completed measures 1 to 2 days before their surgical treatment. The first was an explicit self-report...