A5036381603- Inflammatory Bowel Disease
- Colorectal Cancer Screening and Detection
- Microscopic Colitis
- Genetic factors in colorectal cancer
- Gastric Cancer Management and Outcomes
- Mycobacterium research and diagnosis
- Neuropeptides and Animal Physiology
- Diverticular Disease and Complications
- Intraperitoneal and Appendiceal Malignancies
- Helicobacter pylori-related gastroenterology studies
- Ovarian cancer diagnosis and treatment
- Autoimmune and Inflammatory Disorders
- Eosinophilic Esophagitis
- Gastrointestinal disorders and treatments
- Appendicitis Diagnosis and Management
- Neuroendocrine Tumor Research Advances
- Gastrointestinal motility and disorders
- Receptor Mechanisms and Signaling
- Radiomics and Machine Learning in Medical Imaging
- Gastrointestinal Tumor Research and Treatment
- Cancer Genomics and Diagnostics
- Colorectal Cancer Surgical Treatments
- Esophageal Cancer Research and Treatment
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Treatments and Studies
University of Washington
2019-2025
Wake Forest University
2025
Seattle University
2019-2022
University of Calgary
2011-2020
Calgary Laboratory Services
2011-2019
Foothills Medical Centre
2016-2019
Sheba Medical Center
2015
Cornell University
2014
McGill University
2014
Memorial Sloan Kettering Cancer Center
2014
Histological remission is evolving as an important treatment target in UC. We aimed to develop a simple histological index, aligned endoscopy, correlated with clinical outcomes, and suited apply artificial intelligence (AI) system evaluate inflammatory activity.Using set of 614 biopsies from 307 patients UC enrolled into prospective multicentre study, we developed the Paddington International virtual ChromoendoScopy ScOre (PICaSSO) Histologic Remission Index (PHRI). Agreement multiple other...
Discordance between endoscopic and histologic assessments in Crohn's disease (CD) have been observed, however the prevalence cause are unclear. To assess if a protocolized approach to biopsy collection facilitates understanding of this discordance patients with ileal CD. Patients known CD underwent colonoscopy activity assessment. Three biopsies were taken respectively from an ulcer edge, 7-mm, 14-mm away edge discrete ulcer(s). In no ulcers as controls, same 3-site protocol was applied...
Dye spraying chromoendoscopy (DCE) is recommended for the detection of colonic neoplastic lesions in inflammatory bowel disease (IBD). The majority are visible endoscopically and therefore targeted biopsies appropriate surveillance colonoscopy. To compare three different techniques colonoscopy to detect IBD patients: high definition (HD), (DCE), or virtual (VCE) using iSCAN image enhanced colonoscopy.A randomized non-inferiority trial was conducted determine rates patients with longstanding...
Colorectal glandular-neuroendocrine mixed tumor is an uncommon entity with ill-defined clinicopathologic characteristics. We describe the clinicopathology of 23 new cases and review 67 previously reported cases. Clinically, patients (mean age, 61.9 y; male: female, 1.0:1.1) presented a positive fecal occult blood test or visible rectal bleeding (44%), abdominal pain change in bowel movement pattern (25%), obstruction (19%), weight loss (19%). Endoscopically, tumors as polypoid lesion (57%),...
Inflammation, fibrosis, and muscular hypertrophy lead to thickened bowel in Crohn's disease forming strictures. Ultrasound shear wave elastography (SWE) measures wall stiffness. Contrast-enhanced ultrasound (CEUS) uniquely detects inflammation. We aim correlate SWE of ileal vivo CEUS peak enhancement pathology grades inflammation, hypertrophy.In a prospective institutional review board-approved study, 105 consecutive patients with received ultrasound. At maximal thickness (>4 mm), were...
<b>Background and study aims:</b> A novel high definition colonoscopy imaging technique (i-Scan) can characterize, in detail, colonic mucosa patients with ulcerative colitis, may provide additional information about mucosal healing. The aim of this was to create a more refined histological endoscopic criteria based on order redefine inflammatory activity <b>Patients methods:</b> total 78 colitis were assessed by as well white light endoscopy (WLE). Mayo subscores assigned according WLE...
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignant tumor. Acinar-to-ductal metaplasia (ADM) and pancreatic intraepithelial neoplasia (PanIN) are both precursor lesions that lead to the development of PDAC. Reg family proteins (Reg1A, 1B, 3A/G, 4) group calcium-dependent lectins promote islet growth in response inflammation and/or injuries. The aim this study was establish role for PDAC their clinical value as biomarkers. We found Reg1A Reg3A/G were expressed ADM tissues...
Abstract Background Characterization of colonic lesions in inflammatory bowel disease (IBD) remains challenging. We developed an endoscopic classification visual characteristics to identify colitis-associated neoplasia using multimodal advanced imaging (Frankfurt Advanced Chromoendoscopic IBD LEsions [FACILE] classification). Methods The study was conducted three phases: 1) development – expert panel defined signs and predictors dysplasia and, multivariable logistic regression created the...
Although somatic mutations in colorectal cancer are well characterized, little is known about the accumulation of normal colon before cancer. Here, we have developed and applied an ultrasensitive, single-molecule mutational test based on CRISPR-DS technology, which enables mutation detection at extremely low frequency (<0.001) from patients with without This testing platform revealed that carries common genes, but these more abundant Oncogenic KRAS were observed one third none Patients also...
Ulcerative colitis (UC) is an inflammatory bowel disease (IBD) affecting the colon and rectum characterized by a remitting-relapsing course. To detect mucosal inflammation associated with UC, histology considered most stringent criteria. In turn, histologic remission (HR) correlates improved clinical outcomes has been recently recognized as desirable treatment target. The leading biomarker for assessing presence or absence of neutrophils. Therefore, finding this cell in specific structures...
Pneumatosis cystoides intestinalis (PCI) is a condition with multiple gas-filled cysts within the bowel wall, associated diverse background diseases. Its pathogenesis still mystery. Some previous observations scattered in literature have suggested an association of cystic spaces PCI lymphatics.To further investigate whether results from ballooning lymphatic channels.We did immunostaining podoplanin, mucoprotein preferentially expressed endothelial cells, 13 cases (8 men, 5 women; age range,...
Inflammatory bowel disease [IBD] results particularly from an aberrance of CD4+ helper and regulatory T cells comprises histopathologically chronic active enterocolitis with features reflecting both activity chronicity mucosal inflammation. The exact immunological–histological correlation in IBD is not understood. We studied the between colonic cell subsets [Th1, Th2, Th17, Th22 Treg] histological changes ulcerative colitis [UC] Crohn’s [CD]. subtyping enumeration were achieved by flow...
Aims Inflammatory bowel disease (IBD)-associated precancerous lesions may be adenomatous or non-adenomatous with various histomorphologies. We aim to validate the newly proposed classification, explore neoplastic nature of and elucidate molecular mechanisms underlying different Methods 44 background precursor identified in 53 cases surgically resected IBD-associated colorectal ileal carcinomas were reviewed for histomorphological features (classified into adenomatous, mucinous, sessile...
Abstract Background and Aims A composite endoscopic‐histologic remission is increasingly explored as an important endpoint in ulcerative colitis (UC). We investigated combined for predicting clinical outcomes at 12 months compared with endoscopic alone using the high definition virtual chromoendoscopy (VCE) Paddington International ChromoendoScopy ScOre (PICaSSO) histology scores. Methods Ulcerative patients, prospectively enrolled from 11 international centres, underwent VCE targeted...
Fecal calprotectin (FC) is a common surrogate marker of mucosal healing (MH) in patients with ulcerative colitis (UC) and Crohn's disease (CD). We investigated the optimum FC thresholds for defining endoscopic remission (ER) histological (HR) using advanced techniques.In this cross-sectional study, we collected clinical, endoscopic, data, from 76 UC 41 CD patients. Receiver operating characteristic curves were created to evaluate cut-off predict ER evaluated by Mayo Endoscopic Score (MES),...
Objective Endoscopic and histologic healing in ulcerative colitis (UC) is hypothesized to progress proximally distally, with of the distal rectosigmoid occurring last. However, this has not been empirically verified. Methods We performed a prospective cohort study patients pancolonic UC commencing treatment tumor necrosis factor (TNF) antagonist or vedolizumab. Four biopsies were obtained from each five colonic segments at colonoscopy, both baseline 16–24 weeks after initiation. Independent,...