A5003324835- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- CRISPR and Genetic Engineering
- Colorectal and Anal Carcinomas
- Evolution and Genetic Dynamics
- Colorectal Cancer Screening and Detection
- Colorectal Cancer Treatments and Studies
Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol
2021-2022
University of Washington
2021-2022
Seattle University
2021
Although somatic mutations in colorectal cancer are well characterized, little is known about the accumulation of normal colon before cancer. Here, we have developed and applied an ultrasensitive, single-molecule mutational test based on CRISPR-DS technology, which enables mutation detection at extremely low frequency (<0.001) from patients with without This testing platform revealed that carries common genes, but these more abundant Oncogenic KRAS were observed one third none Patients also...
ABSTRACT While somatic mutations in colorectal cancer (CRC) are well characterized, little is known about the accumulation of normal colon prior to cancer. Here we have developed and applied an ultra-sensitive, single-molecule mutational test based on CRISPR-DS technology, which enables mutation detection at extremely low frequency (<0.001) from patients with without CRC. We found oncogenic KRAS one third CRC but none Patients also carried more TP53 than cancer, these were pathogenic...
<div>Abstract<p>Although somatic mutations in colorectal cancer are well characterized, little is known about the accumulation of normal colon before cancer. Here, we have developed and applied an ultrasensitive, single-molecule mutational test based on CRISPR-DS technology, which enables mutation detection at extremely low frequency (<0.001) from patients with without This testing platform revealed that carries common genes, but these more abundant Oncogenic...
Supplementary Data from Colorectal Cancer Is Associated with the Presence of Driver Mutations in Normal Colon
Supplementary Figure from Colorectal Cancer Is Associated with the Presence of Driver Mutations in Normal Colon
Supplementary Figure from Colorectal Cancer Is Associated with the Presence of Driver Mutations in Normal Colon
Supplementary Data from Colorectal Cancer Is Associated with the Presence of Driver Mutations in Normal Colon
<div>Abstract<p>Although somatic mutations in colorectal cancer are well characterized, little is known about the accumulation of normal colon before cancer. Here, we have developed and applied an ultrasensitive, single-molecule mutational test based on CRISPR-DS technology, which enables mutation detection at extremely low frequency (<0.001) from patients with without This testing platform revealed that carries common genes, but these more abundant Oncogenic...