A5085753911- Gastrointestinal motility and disorders
- Neuropeptides and Animal Physiology
- Ion channel regulation and function
- Helicobacter pylori-related gastroenterology studies
- Congenital gastrointestinal and neural anomalies
- Gastroesophageal reflux and treatments
- Diet and metabolism studies
- Infant Health and Development
- Gut microbiota and health
- Neuroscience and Neuropharmacology Research
- Pediatric Hepatobiliary Diseases and Treatments
- Ion Channels and Receptors
- Gallbladder and Bile Duct Disorders
- Neuroscience of respiration and sleep
- Microscopic Colitis
- Receptor Mechanisms and Signaling
- Cardiac electrophysiology and arrhythmias
- Neuroendocrine regulation and behavior
- Spaceflight effects on biology
- Inflammatory Bowel Disease
- Adenosine and Purinergic Signaling
- Regulation of Appetite and Obesity
- Epilepsy research and treatment
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Ion Transport and Channel Regulation
University of Vermont
2014-2023
Michigan State University
2017
Council of Science Editors
2012
University of Calgary
2004-2012
University of Minnesota
2000
University of Washington
1998
Columbia University
1985-1991
The Ohio State University
1983-1988
* Abbreviations: ASD — : autism spectrum disorder GI gastrointestinal 5-HT serotonin Autism disorders (ASDs) are a set of complex neurodevelopmental defined behaviorally by impaired social interaction, delayed and disordered language, repetitive or stereotypic behavior, restricted range interests. ASDs represent significant public health issue with recent estimates indicating that as many 1% children in the United States diagnosed an ASD.1,2 Many individuals have symptoms associated...
5-HT released from enterochromaffin cells acts on enteric nerves to initiate motor reflexes. 5-HT's actions are terminated by a serotonin reuptake transporter (SERT). In this study, we tested the hypothesis that inflammation leads altered mucosal signaling. Colitis was induced 2,4,6-trinitrobenzene sulfonic acid (TNBS), and experiments were conducted day 6. content, number of 5-HT-immunoreactive cells, proportion epithelial increased twofold in colitis. The amount under basal stimulated...
Serotonin (5-hydroxytryptamine, 5-HT) has been shown to be a neurotransmitter in the enteric nervous system (ENS). Although 5-HT is mediator of slow excitatory postsynaptic potentials evoked by stimulation interganglionic connectives, precise role it plays physiology gut unclear. Research hampered an inadequate knowledge types receptor ENS and thus lack well-characterized antagonists. We now report identification two classes neural receptor, effects activating these receptors on myenteric...
Abstract Patients with postinfective irritable bowel syndrome and Trichinella spiralis ‐infected mice share many features including visceral hypersensitivity disordered motility. We assessed enterochromaffin (EC) numbers serotonin transporter (SERT) using National Institute of Health (NIH) female studied for up to 56 days post‐ T. infection. The effects steroid treatment the T‐cell dependence observed responses were by infection hydrocortisone‐treated or receptor knock out [TCR ( β × δ ) KO]...
The electrical and synaptic properties of myenteric neurones in normal inflamed guinea‐pig distal colons were evaluated by intracellular microelectrode recording. Chronic inflammation was established 6 days following administration trinitrobenzene sulfonic acid (TNBS). In S neurones, only altered inputs as the amplitude fast excitatory postsynaptic potentials significantly larger (31 ± 2 mV compared to 20 1 mV) they more likely receive slow input (85% 55%). AH displayed colitis control...
This investigation was conducted to establish whether guinea-pig trinitrobenzene sulfonic acid (TNBS)-colitis associated with a change in the number of neurones myenteric plexus, and, if so, select subpopulations were affected. Total quantified human (Hu) antiserum, and evaluated antisera directed against choline acetyltransferase, nitric oxide synthase, calretinin, neuronal nuclear protein or vasoactive intestinal peptide (VIP). Colitis loss 20% neurones, most which occurred during first 12...
Fecal microbiota transplantation (FMT) is a promising new strategy in the treatment of Inflammatory Bowel Disease, but long-term delivery systems are lacking. This randomized study was designed as safety and feasibility FMT subjects with mild to moderate UC using frozen, encapsulated oral (cFMT).Subjects were 1:1 receive induction by colonoscopy, followed 12 weeks daily administration frozen cFMT or sham therpay. Subjects for 36 longitudenal clinical assessments included multiple subjective...
Enteroendocrine cells act as sensory transducers, releasing 5-HT and numerous peptides that are involved in regulating motility, secretion, gut sensation. The action of mucosal is terminated by a reuptake transporter (SERT). In this study, we examined the hypothesis ileitis leads to changes enteroendocrine cell populations availability. Ileitis was induced guinea pigs intraluminal injection 2,4,6-trinitrobenzenesulfonic acid experiments were conducted 3, 7, 14 days after treatment. number...
Abstract Regulated release of serotonin (5‐HT) from enterochromaffin (EC) cells activates neural reflexes that are involved in gut motility, secretion, vascular perfusion and sensation. The 5‐HT‐selective reuptake transporter (SERT) terminates serotonergic signalling the intestinal mucosa. aim this investigation was to determine whether mucosal 5‐HT content, release, and/or altered a murine model immune cell‐mediated colitis. Experiments were conducted 6 days after colitis induced by...