A5009105120- Genetic factors in colorectal cancer
- Microscopic Colitis
- Gastrointestinal motility and disorders
- Gut microbiota and health
- Eosinophilic Esophagitis
- BRCA gene mutations in cancer
- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
- Gastrointestinal disorders and treatments
- Biomedical and Engineering Education
- Inflammatory Bowel Disease
- COVID-19 Clinical Research Studies
- Pancreatic and Hepatic Oncology Research
- Helicobacter pylori-related gastroenterology studies
- Clostridium difficile and Clostridium perfringens research
- Gastrointestinal Tumor Research and Treatment
- IgG4-Related and Inflammatory Diseases
- Ovarian cancer diagnosis and treatment
- SARS-CoV-2 and COVID-19 Research
- Gallbladder and Bile Duct Disorders
- Colorectal and Anal Carcinomas
- Colorectal Cancer Treatments and Studies
- Neonatal Health and Biochemistry
- Liver Disease Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
Case Western Reserve University
2024
Royal Shrewsbury Hospital
2021-2022
Princess Royal Hospital
2022
University of Vermont Medical Center
2011-2021
Health Net
2021
University of Vermont
2011-2021
St. Johns Hospital
2021
University of Siena
2021
American Society for Clinical Pathology
2018
Beth Israel Deaconess Medical Center
2018
Fecal microbiota transplantation (FMT) is a promising new strategy in the treatment of Inflammatory Bowel Disease, but long-term delivery systems are lacking. This randomized study was designed as safety and feasibility FMT subjects with mild to moderate UC using frozen, encapsulated oral (cFMT).Subjects were 1:1 receive induction by colonoscopy, followed 12 weeks daily administration frozen cFMT or sham therpay. Subjects for 36 longitudenal clinical assessments included multiple subjective...
Abstract Background Decreased gallbladder smooth muscle (GBSM) contractility is a hallmark of cholesterol gallstone disease, but the interrelationship between lithogenicity, biliary stasis, and inflammation are poorly understood. We studied mouse model disease to evaluate development GBSM dysfunction relative changes in bile composition onset sterile cholecystitis. Methods BALB/cJ mice were fed lithogenic diet for up 8 weeks, tension generated by strips was measured. Smooth Ca 2+ transients...
Genomic medicine is transforming patient care. However, the speed of development has left a knowledge gap between discovery and effective implementation into clinical practice. Since 2010, Training Residents in Genomics (TRIG) Working Group found success building rigorous genomics curriculum with tools aimed at pathology residents postgraduate training years 1–4. Based on TRIG model, interprofessional Undergraduate (UTRIG) was formed. Under aegis Medical Educators Section Association...
Sarcina are gram-positive anaerobic bacteria found to be associated with delayed gastric emptying and outlet obstruction. We describe two cases of co-existing Helicobacter pylori organisms in pediatric siblings presenting within four months each other pyloric obstruction secondary severe gastritis/duodenitis. The co-existence has not, our knowledge, been previously reported. Its characteristic tetrad packeted morphology permits readily identified on routine sections. Detection these biopsies...
- Isolated loss of PMS2 staining is an uncommon immunophenotype in colorectal carcinomas, accounting for approximately 4% tumors with microsatellite instability. Limited information regarding these available the literature.- To compare clinicopathologic features carcinomas isolated by immunohistochemistry to those other forms mismatch repair deficiency.- Ninety-three and 193 deficiency were identified. Forty (43%) cases 35 control (18%) had a known germline mutation or clinical diagnosis...
Hereditary diffuse gastric cancer (HDGC) is a rare, inherited syndrome with at least one fourth of HDGC patients having an autosomal dominantly mutation CDH1 (E-Cadherin). Penetrance relatively high (70-80% lifetime risk for cancer). It important pathologists to recognize the syndrome's phenotype in early lesions: patchy intramucosal signet ring cells often associated pagetoid spread. Due insidious nature this lesion, surveillance limited and currently prophylactic gastrectomy option chosen...
In Brief BACKGROUND: Stage-specific survival for colon cancer improves when more lymph nodes are reported in the surgical specimen. This has led to a minimum standard of identifying 12 as quality indicator. OBJECTIVE: The aim this study was determine whether addition Schwartz solution increases node yield and impacts pathologic staging. DESIGN: is prospective cohort study. SETTING: conducted an academic medical center. PATIENTS: Included were 104 consecutive patients with colorectal cancer....
Embryonal (undifferentiated) sarcoma of the liver (ESL) is a rare malignant neoplasm composed undifferentiated sarcomatous tissue. We are presenting case 74-year-old woman diagnosed with an ESL arising from mesenchymal hamartoma (MHL). Both lesions occur typically in childhood, only reported cases adults. Histologically, mass consisted primarily loose myxoid stroma admixed bland spindle cells and extensive, cystic (lymphangioma-like) degeneration. However, also present peripherally were...
Glomus tumor (glomangioma) is an uncommon pericytic neoplasm derived from glomus cells, which are modified smooth muscle cells of the body. Malignant tumors (glomangiosarcomas) extremely rare mesenchymal neoplasms. There limited reports metastatic malignant within gastrointestinal tract in literature. We report a case 80-year-old woman who presented with vague epigastric discomfort. On computed tomography (CT) imaging, 7.1 cm solid enhancing mass was seen originating gastric antrum and...
Context.— Developing skills related to use of computer-based tools is critical for practicing genomic pathology. However, given the relative novelty genomics education, residency programs may lack faculty members with adequate expertise and/or time implement training. A virtual team-based learning (TBL) environment would make pathology education available more trainees. Objective.— To translate an extensively implemented in-person TBL workshop into a and evaluate both knowledge skill...
Abstract Context.—Recent advances in the understanding of genetic conditions involving female genital tract and mechanisms carcinogenesis this setting affect patient management thus n...