Stephanie N. Spohn

ORCID: 0000-0002-9667-9956
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About
Contact & Profiles
Research Areas
  • Gastrointestinal motility and disorders
  • Gut microbiota and health
  • Helicobacter pylori-related gastroenterology studies
  • Microscopic Colitis
  • Asthma and respiratory diseases
  • Neurobiology of Language and Bilingualism
  • Biomedical and Engineering Education
  • Clostridium difficile and Clostridium perfringens research
  • Pharmacological Effects of Natural Compounds
  • X-ray Spectroscopy and Fluorescence Analysis
  • Probiotics and Fermented Foods
  • Cultural Heritage Materials Analysis
  • Cancer, Stress, Anesthesia, and Immune Response
  • Metallurgy and Cultural Artifacts
  • Alzheimer's disease research and treatments
  • Connexins and lens biology
  • Phenothiazines and Benzothiazines Synthesis and Activities
  • Dementia and Cognitive Impairment Research
  • Herbal Medicine Research Studies
  • Immune Cell Function and Interaction

Bio-Rad (United States)
2020

University of Vermont
2015-2018

Universität Ulm
2016

University of Detroit Mercy
2012

Individuals with higher cognitive reserve are more able to cope pathological brain alterations, potentially due the application of efficient strategies. The extent which an individual's performance can be increased by advantageous conditions differs substantially between patients Alzheimer's dementia (AD) and healthy older adults assessed Testing-the-Limits (TtL) approach. Thus, TtL has been proposed as a tool for early diagnosis AD. Here, we report diagnostic accuracy memory paradigm...

10.3233/jad-151141 article EN Journal of Alzheimer s Disease 2016-05-10

5‐HT 4 receptors are expressed in colonic epithelium, and activation with receptor agonists causes mucus secretion from goblet cells, chloride enterocytes, release enterochromaffin cells. We tested whether this could serve a protective role models of colitis under basal conditions. CD‐1 mice were given DSS (4% w/v for 5 days drinking water) or TNBS (7.5 mg/mL) on day 0. agonist (Tegaserod, 1mg/kg), vehicle, antagonist (GR 113808) plus was delivered by enema daily 1–7 (prevention) 6–15...

10.1096/fasebj.30.1_supplement.1023.10 article EN The FASEB Journal 2016-04-01

The link between inflammatory bowel disease (IBD) and decreased bone density is not completely understood. It known that serotonin can have a negative impact on formation via preosteoblast 5-HT1B stimulation, serotonin-selective reuptake transporter (SERT) expression in inflamed intestinal epithelium, leading to increases 5-HT entering the blood stream from gut. Therefore, we tested hypothesis acting receptors contributing factor colitis-related deficits. Colitis was induced by adding...

10.1096/fasebj.29.1_supplement.854.5 article EN The FASEB Journal 2015-04-01

We have previously shown that 5-HT4 receptors are expressed in colonic epithelium, and agonists produce physiological responses such as mucus secretion from goblet cells, chloride enterocytes, serotonin release enterochromaffin cells. These may protective actions the colon conditions like colitis. To test this hypothesis, we induced colitis CD-1 mice using 4% DSS (w/v) drinking water or a single enema of TNBS (7.5mg/mL 50% ethanol) treated with receptor agonist, Tegaserod (1mg/kg), plus...

10.1096/fasebj.29.1_supplement.854.6 article EN The FASEB Journal 2015-04-01
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