A5041248693- Colorectal Cancer Surgical Treatments
- Anorectal Disease Treatments and Outcomes
- Pelvic floor disorders treatments
- Genetic factors in colorectal cancer
- Coronary Interventions and Diagnostics
- Diverticular Disease and Complications
- Colorectal and Anal Carcinomas
- Cardiac Imaging and Diagnostics
- Gastric Cancer Management and Outcomes
- Acute Myocardial Infarction Research
- Hemophilia Treatment and Research
- Peripheral Artery Disease Management
- Cardiac, Anesthesia and Surgical Outcomes
- Platelet Disorders and Treatments
- Colorectal Cancer Treatments and Studies
- Cancer Genomics and Diagnostics
- Helicobacter pylori-related gastroenterology studies
- Colorectal Cancer Screening and Detection
- Congenital gastrointestinal and neural anomalies
- Inflammatory mediators and NSAID effects
- Appendicitis Diagnosis and Management
- Cerebrovascular and Carotid Artery Diseases
- Intraperitoneal and Appendiceal Malignancies
- Hernia repair and management
- Cutaneous Melanoma Detection and Management
Saint Luke's Hospital
2006-2023
University Hospital Southampton NHS Foundation Trust
2014-2022
University of Southampton
2004-2021
Southampton General Hospital
2008-2021
Saint Luke's Health System
2018-2020
The US Oncology Network
2018
University of Chicago Medical Center
2018
University of Missouri–Kansas City
2011-2017
Deaconess Hospital
2017
Beth Israel Deaconess Medical Center
2017
Twenty-four patients with familial adenomatous polyposis who had previously undergone prophylactic colectomy and advanced duodenal were entered into a randomized trial to assess the effect of non-steroidal anti-inflammatory drug sulindac on rectal polyps. Polyp size number assessed by videotaped duodenoscopy (and rectoscopy in 14 patients) at entry after 6 months treatment; tapes compared two assessors unaware randomization shuffled chronological order recordings. Mucosal cell proliferation...
BACKGROUND: Patients with stomas face many difficulties both physical and psychological. Little is known about the long-term problems impact on patient lifestyle of a permanent stoma. This study was designed to address faced by patients stomas. METHODS: were identified from Stoma Care Department records for years 1985 1992 contacted mail. A questionnaire assess postoperative care, quality life issues, equipment problems. Responses recorded either visual analog scale, choice yes-or-no...
Prophylactic factor replacement in patients with hemophilia B improves outcomes but requires frequent injections. A recombinant IX Fc fusion protein (rFIXFc) a prolonged half-life was developed to reduce the frequency of injections required.
Abstract Aim Little is known about the pathophysiology of low anterior resection syndrome (LARS), and evidence concerning management patients diagnosed with this condition scarce. The aim LARS Expert Advisory Panel was to develop practical guidance for healthcare professionals dealing LARS. Method ‘Management guidelines syndrome’ (MANUEL) project promoted by a team eight experts in assessment After face‐to‐face meeting, strategy agreed create comprehensive, guide covering all aspects that...
Despite the introduction of screening, surveillance, and prophylactic colectomy surgery, patients with familial adenomatous polyposis (FAP) are at risk dying from other malignancies.In order to quantify this identify causes mortality, a retrospective life table analysis was performed on 222 who had undergone total ileorectal anastomosis between 1948 1990. These FAP were compared an age- sex-matched group general population relative calculated.Of patients, 53 have died. In matched expected...
To explore the association between duodenal adenoma and carcinoma in patients with familial adenomatous polyposis (FAP).A multicentre survey of 1262 FAP yielded 47 cases cancer. The cancer was assessed these cases.Adenomatous tissue found within 29 44 (66%) mucosa adjacent to 31 42 (73%) such patients. Adenomas were as a component of, or to, 38 45 (84%) patients.These observations support existence adenomacarcinoma sequence duodenum FAP. Factors associated malignant change included villous...
Abstract The risk of rectal cancer in 224 patients with familial adenomatous polyposis an ileorectal anastomosis has been estimated by life-table analysis. Until the age 50 years cumulative is reasonably low at 10 per cent (95 confidence interval 4.5–16 cent), increasing sharply to 29 18–40 cent) 60 years. This means that surveillance retained rectum older must either be improved or they should undergo restorative proctocolectomy earlier middle age.
The phenotypic expression in familial adenomatous polyposis (FAP) is variable. This study compares the phenotype of 27 patients with an identical 5 base pair (bp) deletion at codon 1309 a group 61 matched FAP where knowledge specific mutations not available and seven other different 24 subjects. Patients have significantly more colorectal polyps time colectomy than age sex controls (p = 0.0001). median number specimens was 4000 (interquartile (IQ) range 3000-4875), compared 600 (IQ 488-1400)...
Internal rectal prolapse (rectal intussusception) and rectocele are frequent clinical findings in patients suffering from refractory constipation that may be best characterized as obstructive defecation syndrome. However, there is still no clear evidence whether the stapled transanal resection (STARR) procedure provides a safe effective surgical option for symptom resolution with syndrome, evidence-based guidelines functional long-term results missing. On basis of need objective evaluation,...
Background Optimal surgical intervention for low-grade haemorrhoids is unknown. Rubber band ligation (RBL) probably the most common intervention. Haemorrhoidal artery (HAL) a novel alternative that may be more efficacious. Objective The comparison of HAL with RBL treatment grade II/III haemorrhoids. Design A multicentre, parallel-group randomised controlled trial. Perspective UK NHS and Personal Social Services. Setting 17 Trusts. Participants Patients aged ≥ 18 years presenting (second-...
PURPOSE: Nonsurgical treatment of anal cancer by radiotherapy alone or combined with chemotherapy is the standard therapy for epidermoid carcinoma canal. Surgery only recommended failures. Very few studies have been devoted to outcome this salvage surgery. The aim study evaluate these results. METHODS: A retrospective review from 1986 1995 revealed 21 patients residual recurrent canal after initial radiotherapy, operated on abdominoperineal resection. Patients were reviewed as age, gender,...
The stapled transanal rectal resection (STARR) in patients with defecation disorders is limited by the shape and capacity of circular stapler. A new device has been recently developed, Contour Transtar stapler, order to improve safety effectiveness STARR technique. study designed confirm this declaration.From January June 2007 a prospective European multicentre consecutive disorder caused internal prolapse underwent assessment perioperative morbidity functional outcome after 6 weeks, 3 12...
We sought to determine the impact of subintimal plaque modification (SPM) on early health status following unsuccessful chronic total occlusion (CTO) PCI.Intentionally dilating space during CTO PCI facilitate flow through dissection planes and improve success repeat attempts is a technique used by some hybrid operators, may restoring distal vessel despite PCI.We studied 138 patients who underwent in 12-center registry. Safety was assessed comparing in-hospital outcomes undergoing with...
Accurate and reliable imaging of pelvic floor dynamics is important for tailoring treatment in disorders; however, two modalities are available. Barium proctography (BaP) widely used, but involves a significant radiation dose. Magnetic resonance (MR) allows visualization all midline structures patients supine. This project investigates whether there measurable differences between BaP MR proctography. Patient preference the tests was also investigated.Consecutive referred were invited to...