A5047910418- Cancer Research and Treatments
- interferon and immune responses
- vaccines and immunoinformatics approaches
- Bacteriophages and microbial interactions
- Virus-based gene therapy research
- Adipokines, Inflammation, and Metabolic Diseases
- ATP Synthase and ATPases Research
- Metabolism and Genetic Disorders
- Hemophilia Treatment and Research
- Kidney Stones and Urolithiasis Treatments
- Platelet Disorders and Treatments
- Regulation of Appetite and Obesity
- Blood Coagulation and Thrombosis Mechanisms
- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Amino Acid Enzymes and Metabolism
- Cancer, Lipids, and Metabolism
- Microbial Metabolic Engineering and Bioproduction
- Tea Polyphenols and Effects
- Nuts composition and effects
- Gut microbiota and health
- Chronic Lymphocytic Leukemia Research
- Biochemical Analysis and Sensing Techniques
- Pediatric Urology and Nephrology Studies
- Porphyrin Metabolism and Disorders
Synlogic (United States)
2017-2024
St. James's Hospital
2014-2018
Biogen (United States)
2013-2014
Beth Israel Deaconess Medical Center
2006-2011
Harvard University
2006-2011
Hadassah Medical Center
2005
Prophylactic factor replacement in patients with hemophilia B improves outcomes but requires frequent injections. A recombinant IX Fc fusion protein (rFIXFc) a prolonged half-life was developed to reduce the frequency of injections required.
An engineered E. coli strain lowers blood ammonia, improves survival in models of hyperammonemia, and demonstrates safety healthy volunteers.
Abstract Purpose: SYNB1891 is a live, modified strain of the probiotic Escherichia coli Nissle 1917 (EcN) engineered to produce cyclic dinucleotides under hypoxia, leading STimulator INterferon Genes (STING) activation in phagocytic antigen-presenting cells tumors and activating complementary innate immune pathways. Patients Methods: This first-in-human study (NCT04167137) enrolled participants with refractory advanced cancers receive repeat intratumoral injections either alone or...
Methionine is an essential proteinogenic amino acid, but its excess can lead to deleterious effects. Inborn errors of methionine metabolism resulting from loss function in cystathionine β-synthase (CBS) cause classic homocystinuria (HCU), which managed by a methionine-restricted diet. Synthetic biotics are gastrointestinal tract-targeted live biotherapeutics that be engineered replicate the benefits dietary restriction. In this study, we assess whether SYNB1353, E. coli Nissle 1917...
<i>Background:</i> Decreased circulating levels of adiponectin, an adipocyte-secreted hormone and endogenous insulin sensitizer, have been associated with several obesity-related malignancies. Thiazolidinedione administration, which increases adiponectin levels, decreases risk for lung cancer. Whether are cancer and/or whether receptors expressed in remains unknown. <i>Methods:</i> We conducted a case-control study 85 patients incidental, histologically confirmed 170...
Short-term energy deprivation reduces leptin concentrations and alters the levels of circulating hormones hypothalamic-pituitary-peripheral axis in lean subjects. Whether reduction concentration during long-term weight loss obese individuals is linked to same neuroendocrine changes seen lean, leptin-sensitive subjects remains be fully clarified.In this study, 24 overweight adults (16 women eight men; body mass index (BMI): 27.5-38.0 kg/m(2)) were prescribed a hypocaloric diet (-500 kcal/day)...
Summary In the phase 3 B‐LONG (Recombinant Factor IX Fc Fusion Protein [ rFIXF c] in Subjects With Haemophilia B) study, rFIXFc demonstrated a prolonged half‐life compared with recombinant factor ( rFIX ), and safety efficacy for prophylaxis treatment of bleeding subjects moderately‐severe to severe haemophilia B. this sub‐analysis, c was evaluated requiring major surgery. Dosing investigator‐determined. Assessments included dosing, consumption, bleeding, transfusions haemostatic response. A...
Introduction: Ammonia levels are used to assess hepatic encephalopathy, but their highly variable in clinical practice. Methods: We studied factors associated with variation ammonia values cirrhotic patients without previous encephalopathy and healthy volunteers (HVs). Results: increased by 12% 18% at 1 2 hour, respectively, after a protein meal 64 ( P < 0.001). In 237 HVs, varied significantly between sites 0.0001). New site-specific upper limits based on HV using strict analysis...
Abstract Understanding the pharmacology of microbiome‐based therapeutics is required to support development new medicines. Strains E. coli Nissle (EcN) were genetically modified and administered cynomolgus monkeys at doses 1 × 10 9 12 colony‐forming units (CFU)/day for 28 days. A clinical study evaluate exposure clearance EcN in healthy volunteers was also performed. Healthy subjects received oral EcN, 2.5 25 CFU 3 times daily days or a single day. In monkeys, replicating strains yielded...
Objective Leptin is an adipocyte secreted hormone and important regulator of neuroendocrine, metabolic, immune function. Both r-metHuLeptin IGF1 administration result in reduced central adipose tissue subjects with highly active antiretroviral therapy-induced metabolic syndrome (HAART-MS) but whether the effects leptin are mediated through increasing IGF levels remains unknown. Methods To assess improves HAART-MS by regulating circulating IGFBPs, we first conducted a cross-sectional study...
Abstract The development of therapeutics depends on predictions clinical activity from pre-clinical data. We have previously described SYNB1618, an engineered bacterial therapeutic (synthetic biotic) for the treatment Phenylketonuria (PKU), a rare genetic disease that leads to accumulation plasma phenylalanine (Phe) and severe neurological complications. SYNB1618 consumes Phe in preclinical models, healthy human volunteers, PKU patients. However, it remains unclear what extent consumption by...
The letter by von Eynatten et al. (1) provides unpublished data on the sensitivity of high–molecular weight (HMW) adiponectin versus total in predicting metabolic outcomes. authors focus only one assay source (enzyme-linked immunosorbent assay; ALPCO Diagnostics, Salem, NH) and do not consider its predictive ability comparison to other assays. Whereas different sample sizes may have contributed varying levels statistical significance, previously derived (2) effect estimates are largely...
Abstract Introduction: SYNB1891 is a live, modified strain of the probiotic E. coli Nissle engineered to produce cyclic dinucleotides under hypoxia leading stimulator interferon genes (STING)-activation in phagocytic antigen-presenting cells tumors and activating complementary innate immune pathways. Methods: This first-in-human study (NCT04167137) enrolling patients with refractory advanced solid or lymphoma receive an intratumoral (IT) injection on Days 1, 8 15 first 21-day cycle then Day...
<h3>Background</h3> SYNB1891 is a live, modified strain of probiotic E. coli Nissle engineered to produce cyclic dinucleotides under hypoxia leading stimulator interferon genes (STING)-activation in phagocytic antigen-presenting cells tumors and activating complementary innate immune pathways. <h3>Methods</h3> This first-in-human study (NCT04167137) enrolled patients with refractory advanced solid receive intratumoral (IT) injections monotherapy or combination atezolizumab. Patients the arms...