A5057006819- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Screening and Detection
- Cardiac, Anesthesia and Surgical Outcomes
- Intraperitoneal and Appendiceal Malignancies
- Hernia repair and management
- Pancreatic and Hepatic Oncology Research
- Surgical Simulation and Training
- Colorectal and Anal Carcinomas
- Gastric Cancer Management and Outcomes
- Bariatric Surgery and Outcomes
- Genetic factors in colorectal cancer
- Pelvic and Acetabular Injuries
- Gallbladder and Bile Duct Disorders
- Anorectal Disease Treatments and Outcomes
- Appendicitis Diagnosis and Management
- HIV Research and Treatment
- Enhanced Recovery After Surgery
- Colorectal Cancer Treatments and Studies
- Sports injuries and prevention
- Pelvic floor disorders treatments
- Neuroendocrine Tumor Research Advances
- Intestinal and Peritoneal Adhesions
- Ovarian cancer diagnosis and treatment
- Abdominal Surgery and Complications
- Minimally Invasive Surgical Techniques
St Mary's Hospital
2013-2025
Imperial College London
2015-2025
Imperial College Healthcare NHS Trust
2012-2023
St Mary's Hospital
2011-2021
St. Mary's Hospital
2000-2021
Newcastle upon Tyne Hospitals NHS Foundation Trust
2020
St. Mary’s Hospital
2002-2019
Warwick Hospital
2018
University of Birmingham
2015-2018
St Mary's Hospital
2018
BackgroundRadical surgery via total mesorectal excision might not be the optimal first-line treatment for early-stage rectal cancer. An organ-preserving strategy with selective could reduce adverse effects of without substantially compromising oncological outcomes. We investigated feasibility recruiting patients to a randomised trial comparing an excision.MethodsTREC was randomised, open-label study done at 21 tertiary referral centres in UK. Eligible participants were aged 18 years or older...
Training within a proficiency-based virtual reality (VR) curriculum may reduce errors during real surgical procedures. This study used scientific methodology for development of VR training laparoscopic cholecystectomy.Inexperienced (had performed fewer than ten cholecystectomies), intermediate (20-50) and experienced (more 100) surgeons were recruited. Construct validity was defined as the ability to differentiate between three levels experience, based on simulator-derived metrics nine basic...
Virtual reality (VR) simulation provides unique training opportunities. This study evaluates whether the deliberate practice (DP) can be successfully applied to simulated laparoscopic cholecystectomy (LC) for enhancement of quality surgical skills.Twenty-six inexperienced surgeons underwent a program LC on VR simulator. Trainees were randomly allocated 1 2 specific protocols 10 sessions comprising total 20 LCs. For each session, control group performed LCs separated by 30 minutes...
Colorectal cancer (CRC) is a major cause of morbidity and mortality in developed countries. Despite operative advances the widespread adoption combined-modality treatment, 5-year survival rarely exceeds 60%. Improving our understanding biological processes involved CRC development progression will help generate new diagnostic prognostic approaches. Previous studies have identified altered metabolism as common feature carcinogenesis, quantitative measurement this activity...
Abstract Aims This study aims to evaluate the long-term effect of bariatric surgery on cardiovascular outcomes patients with obesity. Methods and results A nested cohort was carried out within Clinical Practice Research Datalink. The included 3701 database who had undergone age, gender, body mass index-matched controls. primary endpoint composite fatal or non-fatal myocardial infarction ischaemic stroke. Secondary endpoints alone, stroke incident heart failure, mortality. median follow-up...
BACKGROUND:: Breath VOCs have the potential to noninvasively diagnose cancer.Exhaled breath samples were collected using 2-L double-layered Nalophan bags, and analyzed selected-ion-flow-tube mass-spectrometry. Gold-standard test for comparison was endoscopy luminal inspection computed tomography (CT) confirm cancer recurrence. Three studies conducted: RESULTS:: CONCLUSION:: This study suggests association of a single biomarker with primary presence recurrence CRCa. Further multicenter...
Background Optimal surgical intervention for low-grade haemorrhoids is unknown. Rubber band ligation (RBL) probably the most common intervention. Haemorrhoidal artery (HAL) a novel alternative that may be more efficacious. Objective The comparison of HAL with RBL treatment grade II/III haemorrhoids. Design A multicentre, parallel-group randomised controlled trial. Perspective UK NHS and Personal Social Services. Setting 17 Trusts. Participants Patients aged ≥ 18 years presenting (second-...
Postoperative pain is an important adverse event following inguinal hernia repair. The aim of this trial was to compare postoperative within the first 3 months and 1 year after surgery in patients undergoing open mesh repair using either a self-gripping lightweight polyester or polypropylene fixed with sutures.Adult men Lichtenstein for primary were randomized ProGrip™ standard sutured mesh.In total 557 included final analysis (self-gripping 270, 287). Early scores lower than mesh: mean...
One major obstacle in assessing the efficacy of treatment haemorrhoids and comparison trials has been lack a standardized, validated symptom severity score. This study aimed to develop an objective, symptom-based score for that can be used compare treatments, monitor disease assist surgical decisions.A quality-of-life questionnaire was developed from literature conjunction with expert opinion. The circulated patients confirmed haemorrhoids. A statistical model derive weighted symptoms most...
<h3>ABSTRACT</h3> The older surgical patient is well known to be at high risk of increased mortality and medical complications in the perioperative period. These occur due a variety service related factors. need for physician support recognised liaison models care can reduce length stay (LOS) some specialties. Limited evidence exists evaluating their role emergency planned gastrointestinal surgery. We aimed establish evaluate geriatric elective found that embedded geriatrician process change...
Gut inflammatory diseases cause microbial dysbiosis. Human immunodeficiency virus-1 (HIV) infection disrupts intestinal integrity, subverts repair/renewal pathways, impairs mucosal immunity and propels However, metabolic mechanisms driving repair in virally inflamed gut are not well understood. We investigated the capability of microbes to restore epithelial barriers by using a multipronged approach: an vivo simian virus (SIV)-infected nonhuman primate model HIV/AIDS, ex HIV-exposed human...