A5033164065- Glycosylation and Glycoproteins Research
- Gut microbiota and health
- Esophageal Cancer Research and Treatment
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Inflammatory Bowel Disease
- Helicobacter pylori-related gastroenterology studies
- Galectins and Cancer Biology
- Esophageal and GI Pathology
- Immunotherapy and Immune Responses
- Cancer-related gene regulation
- Pancreatic and Hepatic Oncology Research
- Stress Responses and Cortisol
- Immune Response and Inflammation
- Cancer Cells and Metastasis
- Cytomegalovirus and herpesvirus research
- IL-33, ST2, and ILC Pathways
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Clostridium difficile and Clostridium perfringens research
- Synthesis and biological activity
- Listeria monocytogenes in Food Safety
- Pediatric health and respiratory diseases
- Gastric Cancer Management and Outcomes
- Bacteriophages and microbial interactions
- Health, psychology, and well-being
University of Alabama at Birmingham
2012-2025
University of Kentucky
2020-2023
Emory University
2023
Western Kentucky University
2017
Birmingham–Southern College
2009
Idaho State University
1991
Activation by multi-epitope peptide plus mTOR inhibition depletes flagellin-reactive CD4 + T cells and prevents intestinal inflammation.
The role of aberrant glycosylation in pancreatic ductal adenocarcinoma (PDAC) remains an under-investigated area research. In this study, we determined that the ST6GAL1 sialyltransferase, which adds α2,6-linked sialic acids to N-glycosylated proteins, is upregulated patients with early-stage PDAC, and further increased advanced disease. A tumor-promoting function for was elucidated using tumor xenograft experiments human PDAC cells. Additionally, developed a genetically-engineered mouse...
Gut inflammatory diseases cause microbial dysbiosis. Human immunodeficiency virus-1 (HIV) infection disrupts intestinal integrity, subverts repair/renewal pathways, impairs mucosal immunity and propels However, metabolic mechanisms driving repair in virally inflamed gut are not well understood. We investigated the capability of microbes to restore epithelial barriers by using a multipronged approach: an vivo simian virus (SIV)-infected nonhuman primate model HIV/AIDS, ex HIV-exposed human...
Programmed cell death promotes homeostatic turnover in the epithelium but is dysregulated cancer. The glycosyltransferase ST6Gal-I known to block apoptosis through α2,6-linked sialylation of receptor TNFR1 many types. However, its role has not been investigated gastric epithelial cells or tumorigenesis. We determined that human antral rarely expressed ST6Gal-I, number ST6Gal-I–expressing increased significantly with advancing premalignancy leading mRNA expression levels ST6GAL-I and SOX9...
Locally advanced rectal cancer is typically treated with chemoradiotherapy followed by surgery. Most patients do not display a complete response to chemoradiotherapy, but resistance mechanisms are poorly understood. ST6GAL-1 sialyltransferase that adds the negatively charged sugar, sialic acid (Sia), cell surface proteins in Golgi, altering their function. We therefore hypothesized could mediate chemoradiation inhibiting apoptosis. Patient-derived xenograft and organoid models of lines were...
Toll-like receptor (TLR) 5 has been shown to maintain intestinal homeostasis and regulate host defense against enterobacterial infection. However, how TLR5 expression is regulated its function in the intestine have not fully elucidated. Here we demonstrate that mucosal dendritic cells (DCs), but splenic DCs, express high levels of protein. Alternatively spliced Tlr5 transcripts were identified it did explain selective on DCs. Treatment with various bacterial ligands downregulated BMDC...
Progress in understanding the two naturally occurring central nervous system (CNS) manifestations of listeriosis (meningitis/meningoencephalitis and rhombencephalitis) has been limited by lack small animal models that can readily distinguish between these distinct infections. We report here certain neurotropic strains Listeria monocytogenes spread to brains young otherwise healthy mice cause neurological deficits without causing a fatal bacteremia. The novel described fall within...
Abstract Background Early life stress (ELS) is an environmental trigger believed to promote increased risk of IBD. Our goal was identify mechanisms whereby ELS in mice affects susceptibility and/or severity gut inflammation. Methods We utilized 2 published animal models ELS. In the first model, newborn were separated from dam daily for 4 8 hours starting on postnatal day and then weaned early 17. Control left undisturbed with dams until weaning 21. second fed dexamethasone or vehicle ad...
Cultivating an environment of mutualism between host cells and the microbiota is vital, dysregulation this relationship associated with multiple immune disorders including metabolic skin diseases, asthma, allergy, Inflammatory Bowel Disease (IBD). One prominent mechanism for maintaining homeostasis protective regulatory T cell (Treg)- Immunoglobulin A (IgA) pathway toward antigens, in which Tregs maintain provide critical survival factors to IgA+ B cells. In order amplify Treg-IgA pathway,...
Early life stress (ELS) is an environmental trigger linked to increased risk of inflammatory bowel disease (IBD). Our goal was identify mechanisms whereby ELS in mice affects susceptibility to, and/or severity of, intestinal inflammation. We hypothesized that alters the delicate balance typical homeostatic mediators microenvironment, predisposing ELS-exposed individuals IBD onset or worsened upon a pro-inflammatory triggering event within gut. utilized 2 published animal models ELS. In first...
Abstract The role of aberrant glycosylation in pancreatic ductal adenocarcinoma (PDAC) remains an under-investigated area research. In this study, we determined that the ST6GAL1 sialyltransferase, which adds α2,6-linked sialic acids to N -glycosylated proteins, is upregulated patients with early-stage PDAC, and further increased advanced disease. A tumor-promoting function for was elucidated using tumor xenograft models human PDAC cells. Additionally, developed a genetically-engineered mouse...
Intestinal stromal cells (SCs), which synthesize the extracellular matrix that gives mucosa its structure, are newly appreciated to play a role in mucosal inflammation. Here, we show human intestinal vimentin
Abstract Background In inflammatory bowel disease (IBD), including Crohn’s (CD) and ulcerative colitis (UC), CD4+ T cell-responses to unknown microbial antigens drive intestinal inflammation. Both hypo- or hyperactive anti-microbial innate immunity may underlie these pathogenic T-cell responses. Previously, IgG responses Lachnospiraceae flagellins were detected in spontaneously colitic mice with an immune defect adult CD patients complicated disease. However, whether occur therapy-naïve...