A5059466613- Gut microbiota and health
- Stress Responses and Cortisol
- Birth, Development, and Health
- T-cell and B-cell Immunology
- Sodium Intake and Health
- Inflammatory Bowel Disease
- Climate Change and Health Impacts
- Fatty Acid Research and Health
- Microfluidic and Bio-sensing Technologies
- Nutritional Studies and Diet
- Cystic Fibrosis Research Advances
- Circadian rhythm and melatonin
- Vitamin D Research Studies
- Adrenal Hormones and Disorders
- Erythrocyte Function and Pathophysiology
- Diet and metabolism studies
- Health, psychology, and well-being
- Immunodeficiency and Autoimmune Disorders
- Hormonal Regulation and Hypertension
- Tryptophan and brain disorders
- Thermoregulation and physiological responses
- Infant Nutrition and Health
- Immune Cell Function and Interaction
- Escherichia coli research studies
Johns Hopkins Medicine
2024
Johns Hopkins University
2024
University of Alabama at Birmingham
2020-2023
Abstract Excess dietary salt and salt-sensitivity contribute to cardiovascular disease. Distinct T cell phenotypic responses high hypertension as well influences from environmental cues are not understood. The aryl hydrocarbon receptor (AhR) is activated by ligands, promoting systemic homeostasis. We hypothesized that activating AhR supports CD4+ homeostatic functions, such cytokine production mobilization, in response intake while mitigating salt-sensitive hypertension. In the intestinal...
The gut microbiome regulates many important host physiological processes associated with cardiovascular health and disease; however, the impact of on aldosterone is unclear. Investigating whether microbiota regulate can offer novel insights into how affects blood pressure. In this study, we aimed to determine aldosterone. We used enzyme-linked immunosorbent assays (ELISAs) assess plasma renin activity (PRA) in female male mice which are intact, suppressed, or absent. addition, examined...
Abstract Background Early life stress (ELS) is an environmental trigger believed to promote increased risk of IBD. Our goal was identify mechanisms whereby ELS in mice affects susceptibility and/or severity gut inflammation. Methods We utilized 2 published animal models ELS. In the first model, newborn were separated from dam daily for 4 8 hours starting on postnatal day and then weaned early 17. Control left undisturbed with dams until weaning 21. second fed dexamethasone or vehicle ad...
Significance Both IL10 and ICOSL are risk alleles for inflammatory bowel disease (IBD). The role of IL-10 in preventing gut inflammation is well established experimentally clinically. However, it unclear whether how functions the intestines, might impact susceptibility to inflammation. We found that mice, absence associated with increased accumulation IL-10–producing CD4 T cells but dramatic reductions anti-commensal antibodies, resulting limited recognition antigens implicated progression...
Early life stress (ELS) is an environmental trigger linked to increased risk of inflammatory bowel disease (IBD). Our goal was identify mechanisms whereby ELS in mice affects susceptibility to, and/or severity of, intestinal inflammation. We hypothesized that alters the delicate balance typical homeostatic mediators microenvironment, predisposing ELS-exposed individuals IBD onset or worsened upon a pro-inflammatory triggering event within gut. utilized 2 published animal models ELS. In first...
Abstract To limit immune responses to gut-resident microbes, mucus and the epithelial barrier physically separate host system from microbial communities. Immunoglobulin A (IgA) antibodies are known help regulate colonization functions of mucus-associated commensals. However, mechanisms whereby other isotypes, including IgG, interface with components promote tolerance MA microbes still being unraveled. Our lab previously showed that, in mice impaired production T-dependent (TD) anti-commensal...
Abstract Flagellins from bacteria in the Lachnospiraceae family are immunodominant antigens inflammatory bowel disease. Flagellin is basic unit of flagella which used for bacterial motility and recognized by toll-like receptor 5 (TLR5). Due to diversity flagellated organisms that reside proximity intestinal epithelium, we asked whether this resulted distinct interactions between commensal flagellins immune system. Analysis over 200 flagellins, primarily organisms, revealed a divergence...
OBJECTIVES/GOALS: The overall goal of this study was to determine the effect early life stress (ELS) on intestinal CD4+ T cell immune compartment, at homeostasis and after induction experimental Inflammatory Bowel Disease (IBD). METHODS/STUDY POPULATION: We used a mouse model ELS, maternal separation with weaning (MSEW). IL-10 reporter mice enable analysis IL-10-producing cells. Mice were examined postnatal day 28 impact ELS gut regulatory Plasma levels corticosterone (rodent response...
High salt diets (HSD) promote both inflammation and immunosuppression as shown in numerous studies utilizing salt-sensitive or hypertensive models. However, mechanisms involved the homeostatic immune response to HSD, alone, have not been fully elucidated. Regulatory T cells (FOXP3 + CD4 cells) play a role host protection against disease environmental stressors. Further, recent show that RORt expression by Tregs may represent functional adaptation alterations diet. Thus, we hypothesized these...
Inflammatory bowel diseases (IBD) are chronic disorders of the gastrointestinal tract with peak onset during adolescence. The etiology IBD remains poorly understood, but is believed to involve genetic susceptibility, improper immune regulation, and environmental factors. Psychological stress one trigger that has been associated an increased risk inflammatory diseases. Specifically, previous studies have linked early life (ELS) hypothalamic-pituitary-adrenal (HPA) axis dysfunction ultimately...
Abstract Inflammatory bowel diseases (IBD) are chronic disorders of the gastrointestinal tract with peak onset during adolescence. The etiology IBD remains poorly understood, but is believed to involve genetic susceptibility, improper immune regulation, and environmental factors. Psychological stress one trigger that has been associated an increased risk inflammatory diseases. Specifically, previous studies have linked early life (ELS) hypothalamic–pituitary–adrenal (HPA) axis dysfunction...