A5004197565- Stress Responses and Cortisol
- Fibroblast Growth Factor Research
- Gallbladder and Bile Duct Disorders
- T-cell and B-cell Immunology
- Biliary and Gastrointestinal Fistulas
- Anesthesia and Pain Management
- Nerve Injury and Rehabilitation
- Hypothalamic control of reproductive hormones
- Gut microbiota and health
- Neurological diseases and metabolism
- Nutritional Studies and Diet
- Osteoarthritis Treatment and Mechanisms
- Cystic Fibrosis Research Advances
- Medical Device Sterilization and Disinfection
- Sodium Intake and Health
- Liver Disease Diagnosis and Treatment
- Fatty Acid Research and Health
- Silk-based biomaterials and applications
- Microscopic Colitis
- Inflammatory Bowel Disease
- Abdominal vascular conditions and treatments
- Immune Cell Function and Interaction
- Pediatric Pain Management Techniques
- Mycobacterium research and diagnosis
- Veterinary Oncology Research
University of Alabama at Birmingham
2021-2023
Royal Perth Hospital
2015-2023
Oncology Specialists
2022
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2018-2021
National Institutes of Health
2018-2020
Northwestern University
2007
Cornell University
1997-2007
Northwestern Memorial Hospital
2007
University Gastroenterology
2007
Kobe University
1997
Abstract Excess dietary salt and salt-sensitivity contribute to cardiovascular disease. Distinct T cell phenotypic responses high hypertension as well influences from environmental cues are not understood. The aryl hydrocarbon receptor (AhR) is activated by ligands, promoting systemic homeostasis. We hypothesized that activating AhR supports CD4+ homeostatic functions, such cytokine production mobilization, in response intake while mitigating salt-sensitive hypertension. In the intestinal...
Growth plate chondrocytes undergo sequential differentiation to form the resting zone, proliferative zone (PZ), and hypertrophic (HZ). The important role of microRNAs (miRNAs) in growth was previously revealed by cartilage-specific ablation Dicer, an enzyme essential for biogenesis many miRNAs. To identify specific miRNAs that regulate PZ HZ chondrocytes, we microdissected individual zones from juvenile rats performed miRNA profiling using a solution hybridization method sequencing....
Abstract Background Early life stress (ELS) is an environmental trigger believed to promote increased risk of IBD. Our goal was identify mechanisms whereby ELS in mice affects susceptibility and/or severity gut inflammation. Methods We utilized 2 published animal models ELS. In the first model, newborn were separated from dam daily for 4 8 hours starting on postnatal day and then weaned early 17. Control left undisturbed with dams until weaning 21. second fed dexamethasone or vehicle ad...
Significance Both IL10 and ICOSL are risk alleles for inflammatory bowel disease (IBD). The role of IL-10 in preventing gut inflammation is well established experimentally clinically. However, it unclear whether how functions the intestines, might impact susceptibility to inflammation. We found that mice, absence associated with increased accumulation IL-10–producing CD4 T cells but dramatic reductions anti-commensal antibodies, resulting limited recognition antigens implicated progression...
Adequacy of endoscope disinfection in resource-limited settings is unknown. Adenosine triphosphate (ATP) testing useful for evaluation reprocessing, and ATP <200 relative light units (RLUs) after manual cleaning has been associated with adequacy disinfection.
Sciatic nerve block is performed at the popliteal fossa for various surgical procedures in infants and children. The aim of this study to review magnetic resonance imaging scans children ages assess location division posterior thigh.After Institutional Review Board approval was obtained, measurements bifurcation sciatic thigh were recorded from images that previously obtained ages. Data a database parametric nonparametric statistical analysis performed.Measurements 59 patient images. Using...
Gastric varices are an important complication of portal hypertension. We present here a case bleeding gastric secondary to pancreatic neuroendocrine tumour. To our knowledge, there no other reports in the literature. Such cases always timely and reminder importance considering causes hypertension than cirrhosis, particularly patients with limited risk factors for liver disease.
Early life stress (ELS) is an environmental trigger linked to increased risk of inflammatory bowel disease (IBD). Our goal was identify mechanisms whereby ELS in mice affects susceptibility to, and/or severity of, intestinal inflammation. We hypothesized that alters the delicate balance typical homeostatic mediators microenvironment, predisposing ELS-exposed individuals IBD onset or worsened upon a pro-inflammatory triggering event within gut. utilized 2 published animal models ELS. In first...
In brief: this article, a combination of microdissection, miroRNA profiling and transfection studies identify 3 microRNAs that are highly expressed in the proliferative zone appear to be down-stream mediators PTHrP signaling growth plate.
A rare case of arterio-biliary fistula and haemobilia complicating intra-operative microwave ablation hepatocellular carcinoma in a 58-year-old woman with cirrhosis.
Abstract To limit immune responses to gut-resident microbes, mucus and the epithelial barrier physically separate host system from microbial communities. Immunoglobulin A (IgA) antibodies are known help regulate colonization functions of mucus-associated commensals. However, mechanisms whereby other isotypes, including IgG, interface with components promote tolerance MA microbes still being unraveled. Our lab previously showed that, in mice impaired production T-dependent (TD) anti-commensal...
Abstract Flagellins from bacteria in the Lachnospiraceae family are immunodominant antigens inflammatory bowel disease. Flagellin is basic unit of flagella which used for bacterial motility and recognized by toll-like receptor 5 (TLR5). Due to diversity flagellated organisms that reside proximity intestinal epithelium, we asked whether this resulted distinct interactions between commensal flagellins immune system. Analysis over 200 flagellins, primarily organisms, revealed a divergence...
OBJECTIVES Preoperative biliary drainage ( PBD ) can relieve symptoms of cholestasis, but carries risk procedural complications. Metal stents have wider lumens and longer patency, although plastic PS remain in use. We reviewed the outcomes after patients with cholestasis. METHODS Patients symptomatic cholestasis who were likely to wait for over 2 weeks before surgery thus treated between J anuary 2011 M ay 2015 included. evaluated stenting‐related complications, time interval surgery,...
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IntroductionAn 11-year-old 6-kg neutered male Lhasa Apso–Poodle mix was referred for evaluation of progressive ataxia, collapsing in the pelvic limbs, knuckling left thoracic and severe pain. The owner reported that dog a fight with another 4 days earlier had sustained puncture wound on right rostral portion head. Radiographs obtained by referring veterinarian revealed possible fracture orbital bones maxilla at level first premolar tooth. cleaned chlorhexidine
Inflammatory bowel diseases (IBD) are chronic disorders of the gastrointestinal tract with peak onset during adolescence. The etiology IBD remains poorly understood, but is believed to involve genetic susceptibility, improper immune regulation, and environmental factors. Psychological stress one trigger that has been associated an increased risk inflammatory diseases. Specifically, previous studies have linked early life (ELS) hypothalamic-pituitary-adrenal (HPA) axis dysfunction ultimately...
Abstract The mechanisms that orchestrate the initiation of puberty are not well understood. DLK1 encodes a transmembrane protein interacts with NOTCH1 receptor to negatively regulate NOTCH signaling. Loss-of-function mutations in cause central precocious puberty, suggesting normally inhibits reproductive axis centrally. soluble form DLK1, which is generated by proteolytic cleavage extracellular domain, measurable human serum. We hypothesized serum concentrations decline age and decline,...