A5073013491- Intraperitoneal and Appendiceal Malignancies
- Ovarian cancer diagnosis and treatment
- Appendicitis Diagnosis and Management
- Endometrial and Cervical Cancer Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Renal cell carcinoma treatment
- Pancreatic and Hepatic Oncology Research
- Hernia repair and management
- Uterine Myomas and Treatments
- Peptidase Inhibition and Analysis
- Gastric Cancer Management and Outcomes
- Abdominal Surgery and Complications
- Estrogen and related hormone effects
- Cutaneous Melanoma Detection and Management
- Inhalation and Respiratory Drug Delivery
- AI in cancer detection
- Occupational and environmental lung diseases
- Neuroendocrine Tumor Research Advances
- Radiomics and Machine Learning in Medical Imaging
- Cancer Genomics and Diagnostics
- Intestinal and Peritoneal Adhesions
- Omental and Epiploic Conditions
- Colorectal Cancer Treatments and Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Vitamin D Research Studies
University of Bern
2021-2025
University of Tübingen
2016-2023
Taipei Institute of Pathology
2023
University Children's Hospital Tübingen
2019-2022
Universitätsklinikum Tübingen
2019
Institut Gustave Roussy
2018
Medizinische Hochschule Hannover
2014-2017
Leibniz University Hannover
2014-2016
Cancer Clinic
2016
Ruhr University Bochum
2012-2015
Peritoneal carcinomatosis (PC) is an unmet medical need. Despite recent improvements, systemic chemotherapy has limited efficacy. We report the first application of intraperitoneal as a pressurized aerosol in human patients. Three end-stage patients with advanced PC from gastric, appendiceal, and ovarian origin were treated compassionate therapy. All had received previous chemotherapy. A CO2 loaded doxorubicin 1.5 mg/m2 cisplatin 7.5 (pressurized chemotherapy, PIPAC) was applied into abdomen...
The diagnosis of most cancers is made by a board-certified pathologist based on tissue biopsy under the microscope. Recent research reveals high discordance between individual pathologists. For melanoma, literature reports 25-26% for classifying benign nevus versus malignant melanoma. A recent study indicated potential deep learning to lower these discordances. However, performance in histopathologic melanoma images was never compared directly human experts. aim this perform such first...
Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is a novel technique of chemotherapy. First results obtained with PIPAC in patients advanced peritoneal metastasis (PM) from gastric cancer (GC) are presented.
Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is an experimental drug delivery method that applies into the abdominal cavity as under pressure. We present first results obtained with PIPAC in colorectal peritoneal metastasis (CPM).This a retrospective analysis. was applied 17 consecutive patients pretreated CPM. All had previously undergone surgery, and 16 previous lines of systemic (median, two lines). The mean index (peritoneal cancer index) ± 10. Forty-eight applications...
Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is a novel approach for treating peritoneal carcinomatosis. First encouraging results have been obtained in human patients. However, delivering as an might result increased risk of exposure to health care workers, compared with other administration routes.PIPAC was applied two patients using chemotherapeutic drugs (doxorubicin and cisplatin), air contamination levels were measured under real clinical conditions. Air collected on...
Abstract Background : Multimodal therapeutic strategies have improved the outcome of peritoneal metastases (PM). However, objective assessment therapy response remains difficult in PM, since radiological studies a poor accuracy for low-volumetric disease. There is an obvious need histological gold standard allowing tumor to treatment PM. Content We propose perform punch biopsies with diameter 3 5 mm all four abdominal quadrants. four-tier Peritoneal Regression Grading Score (PRGS), defined...
Peritoneal carcinomatosis is an unmet medical need. Laparoscopy offers a unique opportunity to control and steer the operating environment during surgery by loading carbon dioxide with therapeutic substance creating so-called capnoperitoneum. We have treated human sample of peritoneal from endometrial adenocarcinoma ex vivo just after surgery.A nontoxic agent (Dbait) was aerosolized into box containing diseased peritoneum under pressure 12 mmHg CO(2). Dbait (noncoding DNA fragments) acts...
Quality of Life (QoL) plays an important role in patients with peritoneal metastasis and is deteriorating continuously until death. Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) innovative palliative treatment metastasis. We present the first QoL results under PIPAC therapy.Retrospective analysis QLQ30 questionnaire during repeated courses applications pretreated metastasis.91 (M:F = 40:51, median age 64 (34-77) years) 158 were analyzed. 86% had previously received systemic...
Both in animal models and human patients, pressurized intraperitoneal aerosol chemotherapy (PIPAC) has been shown to improve local bioavailability of peritoneal nodules, as compared with conventional lavage. Pharmacokinetic studies show a low drug concentration peripheral venous blood. However, hepatic renal toxicities induced by delivering chemotherapeutic drugs into the abdomen have not yet investigated.Liver function well toxicity parameters were monitored after eight PIPAC applications...
Efficacy of second-line systemic chemotherapy in recurrent gastric cancer with peritoneal metastasis (RGCPM) is limited. We assessed the feasibility, safety and possible efficacy pressurized intraperitoneal aerosol (PIPAC) patients RGCPM after ⩾1 line palliative intravenous chemotherapy.In this open-label, single-arm, monocentric phase II ICH-GCP clinical trial, were scheduled for three courses PIPAC cisplatin 7.5 mg/m2 doxorubicin 1.5 (PIPAC C/D) every 6 weeks. Patients bowel obstruction or...
Intraperitoneal chemotherapy is limited by tissue penetration. Pressurized intraperitoneal aerosol (PIPAC) has been shown to improve drug uptake utilizing the physical properties of gas and pressure. This study investigated effect adding electrostatic precipitation further enhance pharmacologic this technique. A comparative was performed using an in vivo porcine model. There were 3 cases each group, PIPAC pressurized (ePIPAC), plus 1 negative control comparing distribution 2 tracer...
Aims The four‐tiered peritoneal regression grading score ( PRGS ) assesses the response to chemotherapy in metastasis PM ). is used, for example, assess pressurised intraperitoneal aerosol PIPAC However, reproducibility of currently unknown. We aimed evaluate inter‐ and intraobserver variability . Methods results Thirty‐three patients who underwent at least three treatments as part ‐ OPC 1 or 2 clinical trials Odense University Hospital, Denmark, were included. Prior each therapy cycle,...
Objective: To assess the objective tumor response (OTR) of laparoscopic pressurized intraperitoneal aerosol chemotherapy (PIPAC) in women with gynecologic malignancies and peritoneal carcinomatosis (PC).
Introduction. Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is a novel drug delivery system with superior pharmacological properties for treating peritoneal metastasis (PM). Safety and efficacy results of PIPAC cisplatin/doxorubicin or oxaliplatin from registry cohort are presented. Methods . IRB-approved study. Retrospective analysis. No predefined inclusion criteria, individual therapeutic recommendation by the interdisciplinary tumor board. assessment CTCAE 4.0. Histological...
ObjectiveThe prognostic significance of positive peritoneal cytology in endometrial cancer has long been debated. In 2009, the Fédération Internationale de Gynécologie et d'Obstétrique (FIGO) removed as a staging criterion from system. However, there is still evidence that may decrease survival among patients with cancer. The aim this study was to determine different molecular subgroups.MethodsThis included who underwent primary surgical treatment between 2004 and 2015 at Bern University...
Deciphering cellular components and the spatial interaction network of tumor immune microenvironment (TIME) solid tumors is pivotal for understanding biologically relevant cross-talks and, ultimately, advancing therapies. Multiplexed tissue imaging provides a powerful tool to elucidate complexity in holistic manner. We established cross-validated comprehensive immunophenotyping panel comprising over 121 markers multiplexed using MACSima™ cyclic staining (MICS) alongside an end-to-end...
Abstract Background : Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) is a drug delivery technique with superior pharmacological properties for treating peritoneal metastasis (PM). Adding electrostatic loading ( e PIPAC) as an adjunct to aerosol and artificial hydrostatic pressure improved tissue uptake in preclinical model. Methods We report the first PIPAC use 3 patients PM of hepatobiliary-pancreatic (HBP) origin. All received concomitant palliative systemic chemotherapy that was...