A5008124292- Ovarian cancer diagnosis and treatment
- PARP inhibition in cancer therapy
- Endometrial and Cervical Cancer Treatments
- Virus-based gene therapy research
- CRISPR and Genetic Engineering
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Ferroptosis and cancer prognosis
- Endometriosis Research and Treatment
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- Cancer Mechanisms and Therapy
- Estrogen and related hormone effects
- Lymphatic System and Diseases
- Cancer-related Molecular Pathways
- Cytomegalovirus and herpesvirus research
- Prostate Cancer Treatment and Research
- Animal Virus Infections Studies
- interferon and immune responses
- Molecular Biology Techniques and Applications
- Music Therapy and Health
- Colorectal and Anal Carcinomas
- Uterine Myomas and Treatments
- Nail Diseases and Treatments
- COVID-19 and healthcare impacts
University of Bern
2023-2025
University Hospital of Bern
2023-2025
Peter MacCallum Cancer Centre
2019-2024
University Hospital of Basel
2019
University of Basel
2019
ObjectiveThe prognostic significance of positive peritoneal cytology in endometrial cancer has long been debated. In 2009, the Fédération Internationale de Gynécologie et d'Obstétrique (FIGO) removed as a staging criterion from system. However, there is still evidence that may decrease survival among patients with cancer. The aim this study was to determine different molecular subgroups.MethodsThis included who underwent primary surgical treatment between 2004 and 2015 at Bern University...
Abstract Purpose: The purpose of this study was to evaluate RB1 expression and survival across ovarian carcinoma histotypes how co-occurrence BRCA1 or BRCA2 (BRCA) alterations loss influences in tubo-ovarian high-grade serous (HGSC). Experimental Design: protein classified by immunohistochemistry carcinomas 7,436 patients from the Ovarian Tumor Tissue Analysis consortium. We examined germline BRCA status a subset 1,134 HGSC, related genotype overall (OS), tumor-infiltrating CD8+ lymphocytes,...
Lymphovascular space invasion (LVSI) is a known prognostic factor for oncological outcome in endometrial cancer patients. However, little about the value of LVSI among different molecular subgroups. The aim this study was to determine dependence from signature.This included patients who underwent primary surgical treatment between February 2004 and 2016 at Karolinska University Hospital, Sweden Bern Switzerland (KImBer cohort). All cases had complete analysis performed on tumor according WHO...
Objective To investigate whether a change in the Fagotti score (ΔFagotti) following neoadjuvant chemotherapy is predictive of resection to no residual disease (R0) and survival women diagnosed with ovarian cancer. Methods Women treated for newly cancer between January 2012 June 2021 at Bern University Hospital were included this retrospective cohort study. scores before after treatment assessed potential association status interval debulking surgery defined as (R0), macroscopic diameter...
Lynch syndrome is an inherited tumor caused by a pathogenic germline variant in DNA mismatch repair genes. As the leading cause of hereditary endometrial cancer, international guidelines recommend universal screening women with cancer. However, testing for not yet well established clinical practice. The aim this study was to evaluate adherence our algorithm. A retrospective, single-center cohort conducted all cancer patients undergoing surgical treatment at Bern University Hospital,...
SLN mapping has emerged as a standard of care in endometrial cancer due to its high sensitivity and significant reduction morbidity. Although lymphovascular space invasion (LVSI) is known risk factor for lymph node metastasis recurrence, evidence on the reliability LVSI-positive patients scarce. The aim this study was determine impact LVSI diagnostic performance mapping. This retrospective cohort included with who underwent primary surgical treatment at Bern University Hospital, Switzerland,...
Purpose: Inguinofemoral lymphadenectomy (IFLD) is associated with very high morbidity. Fibrin sealant patches are used in various surgical procedures to prevent hematomas and lymphoceles. Here, we report a single-institution experience of fibrin sealants after IFLD vulvar cancer give an overview the current literature. Patients methods: We retrospectively analyzed outcome data on patients who underwent bilateral between November 2014 June 2016 at University Hospital Basel. A patch...
<h3>Introduction/Background</h3> The prognostic significance of positive peritoneal cytology in endometrial cancer has long been debated. In 2009, the Fédération Internationale de Gynécologie et d'Obstétrique (FIGO) removed as a staging criterion from system. However, there is still evidence that may decrease survival among patients with cancer. aim this study was to determine different molecular subgroups. <h3>Methodology</h3> This included who underwent primary surgical treatment between...
<h3>Introduction/Background</h3> Sentinel lymph node (SLN) mapping has emerged as a standard of care in endometrial cancer, due to its high sensitivity and significant reduction operative morbidity. Although lymphovascular space invasion (LVSI) is known risk factor for node-metastasis recurrence, evidence on the reliability SLN LVSI-positive patients scarce. The aim this study was determine impact LVSI diagnostic performance mapping. <h3>Methodology</h3> This retrospective cohort included...
BACKGROUND AND AIMS OF THE STUDY: Due to its importance for treatment and potential prevention in family members, germline testing BRCA1/2 patients with newly diagnosed ovarian cancer is decisive considered a standard of care. Maintenance therapy poly(ADP-ribose) polymerase (PARP) inhibitors substantially improves progression-free survival BRCA mutations homologous recombination-deficient tumours by inducing synthetic lethality. In Switzerland, they are licensed only these patients....
Introduction Centralization of ovarian cancer treatment is associated with higher rates optimal surgery and longer survival. However, preoperative diagnosis challenging some diagnoses are made incidentally after surgery. This study investigated the surgical oncological outcomes patients incidental findings borderline tumors or who were centralized postoperatively treated a two-stage procedure, compared these those adnexal masses suspected malignancy offered single-stage procedure...
This study aimed to identify unique characteristics in the peripheral blood mononuclear cells (PBMCs) of endometriosis patients and develop a non-invasive early diagnostic tool. Using single-cell RNA sequencing (scRNA-seq), we constructed first atlas PBMCs from based on 107,964 25,847 genes. Within CD16
The aim of this study was to examine the role pre-sacral sentinel lymph nodes (SLNs) in patients with uterine cancer. This retrospective cohort includes endometrial or cervical cancer who underwent minimally invasive indocyanine green SLN mapping at Bern University Hospital from December 2012 2022. A complete ultra-staging SLNs performed all cases. total 616 were included study. mean age 61.6 years (standard deviation ± 13.8) and body mass index 28.2 kg/m2 7.3). Endometrial present 466...
<p>Expression of RB1 and survival associations across ovarian cancer histotypes. <b>A,</b> Representative images IHC detection expression in carcinoma tissues, showing examples the three most common patterns: retained, lost, subclonal loss. <b>B,</b> Proportion patients with loss or retention protein tumor samples by <i>χ</i><sup>2</sup><i>P</i> value reported for difference proportions all CCOC, clear cell cancer; LGSC,...
<p>Supplementary Figure S10. Immune cell subsets inferred from gene expression data by combined homologous recombination deficiency and RB1 status.</p>