Jane Whitney Gibson
A5080984588- Retinal Diseases and Treatments
- Online and Blended Learning
- Management and Organizational Studies
- Lymphoma Diagnosis and Treatment
- Glaucoma and retinal disorders
- Management Theory and Practice
- Cancer Genomics and Diagnostics
- Management and Marketing Education
- Retinal Imaging and Analysis
- Chronic Lymphocytic Leukemia Research
- Genetic Associations and Epidemiology
- Genetic factors in colorectal cancer
- Corneal surgery and disorders
- Organizational Leadership and Management Strategies
- Job Satisfaction and Organizational Behavior
- Esophageal Cancer Research and Treatment
- Genetic Mapping and Diversity in Plants and Animals
- Knowledge Management and Sharing
- Leadership and Management in Organizations
- Immunodeficiency and Autoimmune Disorders
- Epigenetics and DNA Methylation
- Retinal and Optic Conditions
- Accounting and Organizational Management
- Bacteriophages and microbial interactions
- Retinal Development and Disorders
University of Southampton
2016-2025
Florida College
1999-2025
University of Oxford
2025
University of Central Florida
2014-2025
Southampton General Hospital
2009-2024
Massachusetts Eye and Ear Infirmary
2022-2024
Harvard University
2022-2024
Orlando Health
1999-2024
The Christie NHS Foundation Trust
2021-2023
The Christie Hospital
2023
To assess the differences in proteolytic activity of acute and chronic wound environments, fluids were collected from surgical wounds (22 samples) (25 various etiologies, including mixed vessel disease ulcers, decubiti diabetic foot ulcers. Matrix metalloproteinase (MMP) measured using Azocoll assay was significantly elevated by 30 fold (median 22.8 microg MMP Eq/ml) compared to 0.76 (p < 0.001). The addition matrix inhibitor Illomostat decreased approximately 90% all samples, confirming...
Long tracts of consecutive homozygous single nucleotide polymorphisms (SNPs) can arise in the genome through a number mechanisms. These include inbreeding which an individual inherits chromosomal segments that are identical by descent from each parent. However, recombination and other processes break up over generations. The longest therefore to be expected populations with appreciable degree inbreeding. We examined length, distribution long homozygosity apparently outbred HapMap...
Abstract Medical artificial intelligence (AI) offers great potential for recognizing signs of health conditions in retinal images and expediting the diagnosis eye diseases systemic disorders 1 . However, development AI models requires substantial annotation are usually task-specific with limited generalizability to different clinical applications 2 Here, we present RETFound, a foundation model that learns generalizable representations from unlabelled provides basis label-efficient adaptation...
Cadaveric studies have shown disease-related neurodegeneration and other morphological abnormalities in the retina of individuals with Parkinson disease (PD); however, it remains unclear whether this can be reliably detected vivo imaging. We investigated inner retinal anatomy, measured using optical coherence tomography (OCT), prevalent PD subsequently assessed association these markers development a prospective research cohort.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCoke Formation in Catalytic CrackingW. G. Appleby, J. W. Gibson, and M. GoodCite this: Ind. Eng. Chem. Process Des. Dev. 1962, 1, 2, 102–110Publication Date (Print):April 1962Publication History Published online1 May 2002Published inissue 1 April 1962https://pubs.acs.org/doi/10.1021/i260002a006https://doi.org/10.1021/i260002a006research-articleACS PublicationsRequest reuse permissionsArticle Views2442Altmetric-Citations129LEARN ABOUT THESE...
Mounting evidence supports the clinical significance of gene mutations and immunogenetic features in common mature B-cell malignancies.We undertook a detailed characterization genetic background splenic marginal zone lymphoma (SMZL), using targeted resequencing explored potential implications multinational cohort 175 patients with SMZL.We identified recurrent TP53 (16%), KLF2 (12%), NOTCH2 (10%), TNFAIP3 (7%), MLL2 (11%), MYD88 ARID1A (6%), all genes known to be by somatic mutation SMZL....
<h3>Background</h3> Multiple genes have been implicated by association studies in altering inflammatory bowel disease (IBD) predisposition. Paediatric patients often manifest more extensive and a particularly severe course. It is likely that genetic predisposition plays substantial role this group. <h3>Objective</h3> To identify the spectrum of rare novel variation known IBD susceptibility using exome sequencing analysis eight individual cases childhood onset disease. <h3>Design</h3> DNA...
Executive Overview Management fads often get a lot of attention. Should managers be concerned about the latest management fad, or is it just waste time?1 Considerable interest has been shown in literature and fashions. Journal newspaper articles abound,2 professional books have written on subject.3 Unlike many literature-based, academic concepts, these fashions are well known by practicing managers. This article focuses five late 20th century, each one representative trend specific decade:...
Age-related macular degeneration (AMD) is a leading cause of visual loss in Western populations. Susceptibility influenced by age, environmental and genetic factors. Known risk loci do not account for all the heritability. We therefore carried out genome-wide association study AMD UK population with 893 cases advanced 2199 controls. This showed an well-established ARMS2 (age-related maculopathy susceptibility 2)–HTRA1 (HtrA serine peptidase 1) (P =2.7 × 10−72), CFH (complement factor H) =2.3...
Histone methyltransferases (HMTs) are important epigenetic regulators of gene transcription and disrupted at the genomic level in a spectrum human tumours including haematological malignancies. Using high-resolution single nucleotide polymorphism (SNP) arrays, we identified recurrent deletions SETD2 locus 3% (8/261) chronic lymphocytic leukaemia (CLL) patients. Further validation two independent cohorts showed that were associated with loss TP53, complexity chromothripsis. With...
The pathogenesis of splenic marginal zone lymphoma (SMZL) remains largely unknown. Recent high-throughput sequencing studies have identified recurrent mutations in key pathways, most notably NOTCH2 >25% patients. These are based on small, heterogeneous discovery cohorts, and therefore only captured a fraction the lesions present SMZL genome. To identify further novel pathogenic within related biochemical we applied whole exome (WES) copy number (CN) analysis to biologically clinically...
In the context of food security, examining genomics domestication will help identify genes underlying adaptive and economically important phenotypes, for example, larger fruit, improved taste, loss agronomically inferior phenotypes. Examination genome-scale single nucleotide polymorphisms demonstrates relationships between wild ancestors eggplant (Solanum melongena L.), confirming that Solanum insanum L. is progenitor. This species split roughly into an Eastern (Malaysian, Thai, Vietnamese)...
Serum lipids are modifiable, routinely collected blood test features associated with cardiovascular health. We examined the association of commonly serum lipid measures (total cholesterol [TC], high-density lipoprotein [HDL-C], low-density [LDL-C], and triglycerides) intraocular pressure (IOP).Cross-sectional study in UK Biobank European Prospective Investigation into Cancer Nutrition (EPIC)-Norfolk cohorts.We included 94 323 participants from (mean age, 57 years) 6230 EPIC-Norfolk 68...
Better understanding of primary open-angle glaucoma (POAG) genetics could enable timely screening and promote individualized disease risk prognostication.