A5066035206- Long-Term Effects of COVID-19
- Cardiovascular and exercise physiology
- Cardiovascular Health and Disease Prevention
- Intensive Care Unit Cognitive Disorders
- Prenatal Substance Exposure Effects
- COVID-19 and Mental Health
- Congenital Anomalies and Fetal Surgery
- Neonatal Respiratory Health Research
- Angiogenesis and VEGF in Cancer
- Acute Myeloid Leukemia Research
- Osteoarthritis Treatment and Mechanisms
- Cardiovascular Disease and Adiposity
- COVID-19 Clinical Research Studies
- Acute Lymphoblastic Leukemia research
- Health Systems, Economic Evaluations, Quality of Life
- Hematopoietic Stem Cell Transplantation
- Cardiac, Anesthesia and Surgical Outcomes
- Birth, Development, and Health
- Noise Effects and Management
- Cardiac Health and Mental Health
- Thermoregulation and physiological responses
- Vasculitis and related conditions
- Music Therapy and Health
- Congenital Diaphragmatic Hernia Studies
- Hearing Loss and Rehabilitation
University of Huddersfield
2017-2024
The Open University
2023-2024
Australian Football League
2024
University of Leeds
2010-2024
Imperial College London
2024
University of Edinburgh
2022-2023
University of Leicester
2023
University Hospitals of Leicester NHS Trust
2023
NIHR Leicester Biomedical Research Centre
2023
Collaborative Group (United States)
2023
XPD codes for a DNA helicase involved in transcription and nucleotide excision repair. Rare mutations diminish repair resulting hypersensitivity to UV light increased risk of skin cancer. Several polymorphisms this gene have been identified but their impact on is not known. We compared genotypes at codons 312 751 with proficiency 31 women. were measured by PCR–RFLP. was assessed using cytogenetic assay that detects X-ray induced chromatid aberrations (breaks gaps). Chromatid scored per 100...
Objectives To determine whether whole-body MRI defines clinically relevant subgroups within polymyalgia rheumatica (PMR) including glucocorticoid responsiveness. Methods 22 patients with PMR and 16 rheumatoid arthritis (RA), untreated diagnosed by consultant rheumatologists, underwent whole-body, multiple-joint MRI, scored two experts. Patients reported they felt ‘back to normal’ on therapy were followed for a median of 2 years. Results All deemed respond glucocorticoids clinically. A...
We have analysed the behaviour of minimal residual disease (MRD) after allogeneic bone marrow transplantation (allo-BMT) in 71 children with acute lymphoblastic leukaemia (ALL). The method relied on PCR IgH, TCRdelta and/or TCRgamma gene rearrangements followed by electrophoretic size resolution and allele-specific oligoprobing. Patients were similarly conditioned; 55 received from unrelated donors 16 related donors. MRD was assessed at various time-points up to 24 months BMT. Three not...
Moderate‐intensity endurance exercise training improves vascular endothelial vasomotor function; however, the impact of high‐intensity has been equivocal. Thus, effect physiological stress remains poorly understood. Furthermore, enhanced repair mediated by circulating progenitor cells may also be improved. To address whether is an important factor contributing to these adaptations, 20 healthy participants trained for 6 weeks. Training involved either moderate (MSIT; n = 9) or heavy metabolic...
The optimum route for drug administration in cardiac arrest is unclear. Recent data suggest that use of the intraosseous may be increasing. This study aimed to explore changes over time and intravenous routes out-of-hospital England.We extracted from UK Out-of-Hospital Cardiac Arrest Outcomes registry. We included adult patients between 2015-2020 who were treated by an English Emergency Medical Service submitted vascular access primary outcome was any during arrest. used logistic regression...
Abstract Background The ‘Prehospital Assessment of the Role Adrenaline: Measuring Effectiveness Drug Administration In Cardiac Arrest’ (PARAMEDIC2) trial showed that adrenaline improves overall survival, but not neurological outcomes. We sought to determine within-trial and lifetime health social care costs benefits associated with adrenaline, including secondary from organ donation. Methods estimated costs, (quality-adjusted life years (QALYs)) incremental cost-effectiveness ratios (ICERs)...
Traditional continuous aerobic exercise training attenuates age-related increases of arterial stiffness, however, studies have not determined whether metabolic stress impacts these favourable effects. Twenty untrained healthy participants (n = 11 heavy interval training, n 9 moderate training) completed 6 weeks or intensity matched for total work and duration. Carotid artery blood pressure contour analysis, linear non-linear heart rate variability were assessed before following training....
Non-invasive forearm ischemia-reperfusion injury and low flow induced vascular dysfunction models provide methods to evaluate function. The role of oestrogen, an endogenous anti-oxidant on recovery from has not been evaluated nor the impact prolonged function established. Eight healthy women (33±10 yr) attended lab during follicular, ovulatory mid-luteal phases their menstrual cycles. After 30 minutes rest, brachial artery was assessed by ultrasound measurements diameter changes 5 ischemia 3...
Introduction The improvement of vascular health in the exercising limb can be attained by sprint interval training (SIT). However, effects on systemic function and circulating angiogenic cells (CACs) which may contribute to endothelial repair have not been investigated. Additionally, a comparison between SIT continuous (SCT) is less time committing has made. Methods 12 women (22±2 yrs) completed sessions either (n = 6) or work-matched SCT 3 days/week. Pre post-training assessments included...
In polymyalgia rheumatica (PMR), glucocorticoids (GCs) relieve pain and stiffness, but fatigue may persist. We aimed to explore the effect of disease, GCs PMR symptoms in metabolite signatures peripheral blood from patients with or related giant cell arteritis (GCA).
Background: Hospital in-patients need sleep so that restorative process and healing can take place. However, over one third of experience disturbance, often caused by noise. This compromise patients’ perceptions care quality cause physical psychological ill health. Aims: To assess 1) quality, quantity, reported sources disturbance their suggestions for improvement 2) objectively measure decibel levels recorded at night. Methods: descriptive study conducted in a Medical Assessment Unit used...