A5039496972- Bone health and osteoporosis research
- Rheumatoid Arthritis Research and Therapies
- Hip and Femur Fractures
- Systemic Lupus Erythematosus Research
- Spondyloarthritis Studies and Treatments
- Autoimmune and Inflammatory Disorders Research
- Bone and Joint Diseases
- Vasculitis and related conditions
- Bone health and treatments
- Nutrition and Health in Aging
- Musculoskeletal Disorders and Rehabilitation
- COVID-19 Clinical Research Studies
- Bone fractures and treatments
- Hip disorders and treatments
- Otitis Media and Relapsing Polychondritis
- Chronic Lymphocytic Leukemia Research
- SARS-CoV-2 and COVID-19 Research
- Lymphoma Diagnosis and Treatment
- Psoriasis: Treatment and Pathogenesis
- Long-Term Effects of COVID-19
- Metabolism and Genetic Disorders
- Health Systems, Economic Evaluations, Quality of Life
- Vitamin D Research Studies
- Inflammatory Myopathies and Dermatomyositis
- Systemic Sclerosis and Related Diseases
Lancaster University
2015-2025
Royal Lancaster Infirmary
2016-2025
University of Manchester
2001-2024
University Hospitals of Morecambe Bay NHS Foundation Trust
2015-2024
Pakistan Institute of Development Economics
2024
NIHR Manchester Biomedical Research Centre
2023-2024
Versus Arthritis
2023-2024
University of Central Lancashire
2024
Manchester University NHS Foundation Trust
2022-2023
Manchester Academic Health Science Centre
2023
Inhibitors of TNF-a represent important treatment advances for a number inflammatory conditions, including RA. inhibitors offer targeted strategy that contrasts with the non-specific immunosuppressive agents traditionally used to treat most forms systemic inflammation. Information on who benefits from these and their adverse effects continues be collected through clinical studies, case series reports national registries. In 2001 2005, British Society Rheumatology (BSR) established updated...
Abstract Objective To identify the relative contributions of clinical and laboratory variables, determined at baseline, in predicting deterioration radiographic damage 5 years after presentation patients with inflammatory polyarthritis. Methods Data from 439 subjects who sought primary care for polyarthritis were analyzed. All had paired radiographs, which first was obtained within 24 months second presentation. The contribution baseline variables degree radiologic severity as judged by...
Abstract Objective To determine the effect of early treatment with disease‐modifying antirheumatic drugs (DMARDs) in reducing radiographic progression over a 5‐year period patients new‐onset inflammatory polyarthritis. Methods Three hundred thirty‐five consecutive paired radiographs obtained 1 year and 5 years after enrollment population‐based arthritis register were studied. Logistic regression was used to model differences baseline factors associated start DMARDs. The time from symptom...
SUMMARY The aims of this study were (i) to determine whether PlGF, VEGF and PlGF/VEGF heterodimers are detected in synovial fluid (SF) plasma samples from patients with a range arthropathies; (ii) describe any correlation exists between SF heterodimer levels the total differential leucocyte counts; (iii) investigate regulation peripheral blood mononuclear cell (PBMC) secretion by stimuli relevant inflammatory joints. measured arthropathies normal controls ELISA. Western blotting for PlGF was...
Abstract Objective Anti–cyclic citrullinated peptide (anti‐CCP) antibodies are a stronger predictor of the severity rheumatoid arthritis than is factor (RF). Their role in predicting outcome unselected patients with new‐onset inflammatory polyarthritis (IP) has not been examined. The aims this study were to examine baseline RF and anti‐CCP determining likelihood having erosions at presentation or future radiologic damage, determine whether sufficiently robust be clinically useful guiding...
In order to develop interventions optimize MTX use for the treatment of RA we evaluated rate of, reasons and predictors non-adherence during first 6 months therapy.The Rheumatoid Arthritis Medication Study (RAMS) is a prospective multicentre cohort study incident users in UK. Prior commencement demographic, clinical psychological data were collected. A weekly patient-completed diary recorded dose, possible side effects adherence over 26 weeks. The number non-adherent weeks was calculated....
Abstract Objectives The existing guidelines for PsA cover many aspects of management. Some gaps remain relating to routine practice application. An expert group aimed enhance the current guidance and develop recommendations clinical that are complementary guidelines. Methods A steering committee comprising experienced, research-active clinicians in rheumatology, dermatology primary care agreed on themes relevant questions. targeted literature review PubMed Embase following a PICO framework...
: To assess nailfold capillary density and dimensions in patients with primary Raynaud's phenomenon (PRP), limited cutaneous systemic sclerosis (LSSc) diffuse SSc (DSSc), healthy control subjects.: Using the technique of video capillaroscopy, were averaged from all visible capillaries a 3 mm length right left ring fingers each subject. Twenty subjects, 15 PRP, 13 DSSc 21 LSSc examined. Intra-observer inter-observer variability calculated 18 23 patients, respectively.: There significant...
To determine the effect of treatment with disease-modifying antirheumatic drugs (DMARDs) and/or steroids on 5-year disability outcome in patients inflammatory polyarthritis.Three hundred eighty-four registered by Norfolk Arthritis Register (a primary care-based observational cohort) were followed up for 5 years. Treatment details and Health Assessment Questionnaire (HAQ) scores recorded annually. Logistic regression was used to model differences baseline factors associated start DMARDs...
Chris Deighton1, Kimme Hyrich2, Tina Ding1, Jo Ledingham3, Mark Lunt2, Raashid Luqmani4, Patrick Kiely5, Marwan Bukhari6, Rikki Abernethy7, Andrew Ostor8, Ailsa Bosworth9, Kate Gadsby1, Frank McKenna10, Diana Finney11 and Josh Dixey12, on behalf of BSR Clinical Affairs Committee & Standards, Audit Guidelines Working Group the BHPR 1Rheumatology Department, Royal Derby Hospital, Derby; 2ARC Epidemiology Unit, University Manchester, Manchester; 3Rheumatology Queen Alexandra Portsmouth;...
Abstract Objectives To investigate the frequency and predictors of sustained 28-joint DAS (DAS28) remission low disease activity (LDA) in patients receiving anti-TNF therapy changes responses over a 12 year period. Methods Data from British Society for Rheumatology Biologics Registry Rheumatoid Arthritis were used. Sustained LDA defined according to DAS28-ESR thresholds 6 months. The dataset was dichotomized into sequential chronological subgroups (2001–2010 2010–2013). Predictive variables...
Abstract Objectives To estimate prevalence rates and identify baseline predictors of adverse events (AEs) over the first year treatment in patients with RA starting MTX. Methods Data came from UK Rheumatoid Arthritis Medication Study (RAMS), a prospective cohort This analysis included aged ≥18 years physician diagnosed symptom duration ≤2 years, who were commencing MTX for time. AEs recorded by interviewing at 6- 12-month follow-up visits. The period are reported 0–6 months, 6–12 months 0–12...
Abstract Background/Aims The effect of thyrotoxicosis on percentage body fat (%BF) has been widely researched, with studies showing a reduction in overall %BF caused by an increase thyroid hormones, due to the basal metabolic rate. Thyrotoxicosis is also associated increased fracture risk, stimulation osteoclast and osteoblast activity, eventually resulting decrease bone mineral density (BMD). aim this retrospective observational cohort study was evaluate whether at specific sites had any...
Abstract Background/Aims Height is a significant factor in predicting fracture outcomes especially among female patients, with reports demonstrating increased risk taller individuals. Accurate assessment tools are essential to prevent major source of morbidity and reduce the mortality that follows. Within one-year post-fracture, absolute 12.5% women 19.5 % men, highlighting critical need for precise prediction models can guide preventative care.This retrospective cohort study evaluates...
To examine the time of occurrence first radiographic erosions in a cohort patients with inflammatory polyarthritis.Patients were recruited through Norfolk Arthritis Register, which follows up annually. Patients features rheumatoid arthritis (other than erosions) sufficient, together erosions, to meet American College Rheumatology (formerly, Rheumatism Association) 1987 revised criteria requested undergo examinations hands and feet at and/or second annual followup visits. All fifth visit. The...
The aim of the study was to measure nailfold capillary dimensions and density in patients with primary Raynaud's phenomenon (PRP) systemic sclerosis (SSc) compared control subjects. Ten controls, nine PRP 10 SSc were studied. All other than distance between limbs significantly increased both groups controls (P < 0.01), group showing most marked increases (SSc vs PRP, P 0.05 for all dimensions). Capillary reduced = 0.004). These results suggest that structural vascular changes occur as well...
The Standards, Audit and Guidelines Working Group (SAGWG) of the British Society for Rheumatology (BSR) have recently updated guidelines on eligibility anti-TNF drugs in RA [1] safety efficacy [2] general use rheumatology community. National Institute Heath Clinical Excellence (NICE) UK, which is an independent organization responsible providing national guidance UK promoting good health preventing treating ill health, has published a technology appraisal [3] rituximab 2007. Furthermore,...