V. Saravanan
A5028685931- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Rheumatoid Arthritis Research and Therapies
- Salivary Gland Disorders and Functions
- Sulfur-Based Synthesis Techniques
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Systemic Sclerosis and Related Diseases
- Systemic Lupus Erythematosus Research
- Sarcoidosis and Beryllium Toxicity Research
- Plant Virus Research Studies
- Organoselenium and organotellurium chemistry
- Lymphoma Diagnosis and Treatment
- Synthesis and Catalytic Reactions
- Vasculitis and related conditions
- Growth Hormone and Insulin-like Growth Factors
- Synthesis and biological activity
- Catalytic C–H Functionalization Methods
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Transgenic Plants and Applications
- Connective tissue disorders research
- Bacteriophages and microbial interactions
- Phenothiazines and Benzothiazines Synthesis and Activities
- Advanced Synthetic Organic Chemistry
- Viral Infectious Diseases and Gene Expression in Insects
- Chemical Synthesis and Analysis
Queen Elizabeth Hospital
2014-2024
Saveetha University
2023
Versus Arthritis
2023
University of Manchester
2023
Manchester Academic Health Science Centre
2023
Gateshead Health NHS Foundation Trust
2009-2022
Jubilant Life Sciences (India)
2016-2021
University of Madras
2013-2015
Newcastle University
2014
Jain University
2014
BackgroundImmunosuppressive treatments inhibit vaccine-induced immunity against SARS-CoV-2. We evaluated whether a 2-week interruption of methotrexate treatment immediately after the COVID-19 vaccine booster improved antibody responses S1 receptor-binding domain (S1-RBD) SARS-CoV-2 spike protein compared with uninterrupted in patients immune-mediated inflammatory diseases.MethodsWe did an open-label, prospective, two-arm, parallel-group, multicentre, randomised, controlled, superiority trial...
Background Fatigue is a debilitating condition with significant impact on patients' quality of life. frequently reported by patients suffering from primary Sjögren's Syndrome (pSS), chronic autoimmune characterised dryness the eyes and mouth. However, although fatigue common in pSS, it does not manifest all sufferers, providing an excellent model which to explore potential underpinning biological mechanisms. Methods Whole blood samples 133 fully-phenotyped pSS stratified for presence...
Heterogeneity is a major obstacle to developing effective treatments for patients with primary Sjögren's syndrome. We aimed develop robust method stratification, exploiting heterogeneity in patient-reported symptoms, and relate these differences pathobiology therapeutic response.
EuroQoL-5 dimension (EQ-5D) is a standardised preference-based tool for measurement of health-related quality life and EQ-5D utility values can be converted to quality-adjusted years (QALYs) aid cost-utility analysis. This study aimed evaluate the 639 patients with primary Sjögren's syndrome (PSS) in UK.Prospective data collected using pro forma were compared UK normative data. Relationships between clinical laboratory features PSS explored.The proportion reporting any problem mobility,...
Objectives This article reports relationships between serum cytokine levels and patient-reported of fatigue, in the chronic immunological condition primary Sjögren's syndrome (pSS). Methods Blood 24 cytokines were measured 159 patients with pSS from United Kingdom Primary Syndrome Registry 28 healthy non-fatigued controls. Differences cases controls evaluated using Wilcoxon test. Patient-reported scores for fatigue evaluated, classified according to severity compared analysis variance....
Fibromyalgia and joint hypermobility are common coexisting conditions among younger females that often accompanied with additional features of autonomic dysfunction. Mental health is frequently impacted these an association neurodivergence has been recently established. Neurodivergence also prevalent close relatives. Reasons for this poorly understood, although genetics, adverse early life experiences autoimmunity all contribute. Pharmacological responses may differ in neurodivergence, while...
<h3>Introduction</h3> Immunisation against pneumococcus has been shown to reduce pneumonia in rheumatoid arthritis (RA). There is concern that methotrexate may its efficacy. are very few objective data on the effect of efficacy pneumococcal vaccination with pneumovax, and no evidence whether revaccination necessary RA patients methotrexate. <h3>Methods</h3> The authors collected information from 180 relating their status assayed antibody levels. Data pulmonary infection were retrieved same...
To determine the prevalence of autonomic dysfunction (dysautonomia) among patients with primary Sjögren's syndrome (PSS) and relationships between dysautonomia other clinical features PSS.Multicentre, prospective, cross-sectional study a UK cohort 317 clinically well-characterised PSS. Symptoms were assessed using validated instrument, Composite Autonomic Symptom Scale (COMPASS). The data compared an age- sex-matched community controls. symptoms various PSS analysed regression...
In order to develop interventions optimize MTX use for the treatment of RA we evaluated rate of, reasons and predictors non-adherence during first 6 months therapy.The Rheumatoid Arthritis Medication Study (RAMS) is a prospective multicentre cohort study incident users in UK. Prior commencement demographic, clinical psychological data were collected. A weekly patient-completed diary recorded dose, possible side effects adherence over 26 weeks. The number non-adherent weeks was calculated....
Abstract Objectives To estimate prevalence rates and identify baseline predictors of adverse events (AEs) over the first year treatment in patients with RA starting MTX. Methods Data came from UK Rheumatoid Arthritis Medication Study (RAMS), a prospective cohort This analysis included aged ≥18 years physician diagnosed symptom duration ≤2 years, who were commencing MTX for time. AEs recorded by interviewing at 6- 12-month follow-up visits. The period are reported 0–6 months, 6–12 months 0–12...
ABSTRACT Introduction Anaemia is common in rheumatoid arthritis (RA). Clinicians may focus on rheumatological issues and assume anaemia of chronic disease (ACD). This study challenged this assumption investigated the causes a large cohort RA patients to assess its implications. Methods The hospital where was conducted monitors regular full blood count erythrocyte sedimentation rate (ESR) monthly all modifying drugs efficacy safety. A computerised system identifies records abnormal results....
BackgroundMethotrexate is the first-line treatment for immune-mediated inflammatory diseases and reduces vaccine-induced immunity. We evaluated if a 2-week interruption of methotrexate immediately after COVID-19 booster vaccination improved antibody response against S1 receptor binding domain (S1-RBD) SARS-CoV-2 spike protein live neutralisation compared with uninterrupted in patients diseases.MethodWe did multicentre, open-label, parallel-group, randomised, superiority trial secondary-care...
To develop a novel method for capturing the discrepancy between objective tests and subjective dryness symptoms (a sensitivity scale) to explore predictors of sensitivity.Archive data from UK Primary Sjögren's Syndrome Registry (n = 688) were used. Patients classified on scale -5 (stoical) +5 (sensitive) depending degree their classes. Sensitivity scores correlated with demographic variables, disease-related factors, pain, fatigue, anxiety, depression.Patients average relatively stoical both...
Abstract Objective GCA is the commonest primary systemic vasculitis in adults, with significant health economic costs and societal burden. There wide variation access to secondary care services, 34% of hospitals England not having any formal clinical pathway. Quality standards provide levers for change improve services. Methods The multidisciplinary steering committee were asked anonymously put forward up five aspects service essential best practice. Responses qualitatively analysed identify...
The aim of the study was to evaluate levels physical activity in individuals with primary Sjögren's syndrome (PSS) and its relationship clinical features PSS. To this cross-sectional study, self-reported from 273 PSS patients were measured using International Physical Activity Questionnaire-short form (IPAQ-SF) compared healthy controls matched for age, sex body mass index. Fatigue other aspects including disease status, dryness, daytime sleepiness, dysautonomia, anxiety depression assessed...