A5053493311- Salivary Gland Disorders and Functions
- Galectins and Cancer Biology
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Cytokine Signaling Pathways and Interactions
- Systemic Lupus Erythematosus Research
- Diabetes and associated disorders
- Asthma and respiratory diseases
- Genetic Neurodegenerative Diseases
- IL-33, ST2, and ILC Pathways
- Adipokines, Inflammation, and Metabolic Diseases
- Growth Hormone and Insulin-like Growth Factors
- Heme Oxygenase-1 and Carbon Monoxide
- Aquaculture Nutrition and Growth
- Pediatric Hepatobiliary Diseases and Treatments
- Salivary Gland Tumors Diagnosis and Treatment
- Biochemical effects in animals
- Cancer Immunotherapy and Biomarkers
- Lymphoma Diagnosis and Treatment
- Psoriasis: Treatment and Pathogenesis
- MicroRNA in disease regulation
- Glycosylation and Glycoproteins Research
- Chemokine receptors and signaling
- Aquaculture disease management and microbiota
- Parasitic infections in humans and animals
- Fibroblast Growth Factor Research
University of Basrah
2015-2025
Newcastle University
2014-2019
University Medical Center Utrecht
2017
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2015
King Khaled Eye Specialist Hospital
2015
Oklahoma Medical Research Foundation
2015
University of California, San Francisco
2015
Hospital Clínic de Barcelona
2015
Background Fatigue is a debilitating condition with significant impact on patients' quality of life. frequently reported by patients suffering from primary Sjögren's Syndrome (pSS), chronic autoimmune characterised dryness the eyes and mouth. However, although fatigue common in pSS, it does not manifest all sufferers, providing an excellent model which to explore potential underpinning biological mechanisms. Methods Whole blood samples 133 fully-phenotyped pSS stratified for presence...
To assess the relationships between systemic IFN type I (IFN-I) and II (IFN-II) activity disease manifestations in primary SS (pSS). RT-PCR of multiple IFN-induced genes followed by principal component analysis whole blood RNA 50 pSS patients was used to identify indicator IFN-I IFN-II activities. Systemic activation levels were analysed two independent European cohorts (n = 86 55, respectively) their with clinical features analysed. Three groups could be stratified according activity:...
Heterogeneity is a major obstacle to developing effective treatments for patients with primary Sjögren's syndrome. We aimed develop robust method stratification, exploiting heterogeneity in patient-reported symptoms, and relate these differences pathobiology therapeutic response.
Asthma is a heterogenic chronic inflammation of the lower respiratory tract. highly prevalent in Basrah city. This study aimed to investigate effect SOCS (SOCS1 & SOCS3) at molecular level on production several cytokines (IL-6, IL-17 and IL-31) asthma. The current included total 80 participants, 54 asthmatic patients 26 heathy controls. levels IL-6, IL-31 were estimated by ELISA while SOCS1 gene polymorphism -1478 CA>del (rs33989964) was detected RFLP-PCR. In addition, SOCS3...
Background. Osteoporosis is a bone disease characterized by low mass and micro-architectural weakening of tissue. It can be influenced, in part, immunological activity. Therapeutically targeting immune factors that promote osteoporosis could protect larger number susceptible individuals, especially postmenopausal women, from this debilitating disease. The aim the present study to evaluate blood levels gene expression for RANKL, RANK, OPG, OSCAR, transcription RORᵧt FOXP3 (as representatives...
Chronic Fatigue Syndrome (CFS) is a prevalent debilitating condition that affects approximately 250,000 people in the UK. There growing interest role of mitochondrial function and DNA (mtDNA) variation CFS. It now known fatigue common often severe patients with disease irrespective their age, gender or mtDNA genotype. More recently, it has been suggested some CFS harbour clinically proven mutations. MtDNA sequencing 93 from United Kingdom (UK) South Africa (RSA) was performed using an Ion...
Resolving the molecular details of proteome variation in different tissues and organs human body will greatly increase our knowledge biology disease.The Human Protein Atlas (www.proteinatlas.org)project employs an antibody-based proteomics approach to systematically map distribution relative abundance proteins a multitude normal tissues, cancer cells.In this talk, tissue based on integrated omics that involves quantitative transcriptomics at organ level, combined with microarray-based...
Asthma is a well-known illness of the lower respiratory tract. It has many phenotypes including allergic and non-allergic asthma. The mechanism still not entirely understood. aim study to investigate IL-4 response during Blood from asthma patients aged matched healthy controls were collected complete blood count (CBC) was performed on each sample serum level IgE estimated by enzyme linked immunosorbent assay (ELISA). results current showed that majority asthmatic between 51-60 years old with...
Colorectal cancer (CRC) is classified as one of the most prevalent types worldwide, with high morbidity and mortality rates. Patients CRC have been shown to express a detectable cytokine in serum which contributes pathogenesis. Therefore, interleukin 10 (IL-10) level patients was investigated this study. Patients' medical records admitted Rizgary Nanakali hospitals, Erbil, Iraq analyzed study group compared healthy volunteers' control group. Seventy-one samples were collected, thirty-one...
<h3>Background/Purpose</h3> Micro RNAs (miRNAs) are 18–25 nt non-coding that bind target/complementary sequences within the 3'UTR of RNA molecules steering them towards degradation or translational repression, and play a key role in regulation gene expression. Better understanding expression pattern miRNAs diseases may improve our biological basis disease identify potential biomarkers. The primary Sjögren's syndrome (PSS) PSS-related lymphoma remains poorly understood. aim this project is to...
Resolving the molecular details of proteome variation in different tissues and organs human body will greatly increase our knowledge biology disease.The Human Protein Atlas (www.proteinatlas.org)project employs an antibody-based proteomics approach to systematically map distribution relative abundance proteins a multitude normal tissues, cancer cells.In this talk, tissue based on integrated omics that involves quantitative transcriptomics at organ level, combined with microarray-based...
<h3>Background</h3> Lymphoma development is a serious complication of Primary Sjögren9s syndrome (pSS). To date, the biological processes that may be involved in pSS-associated lymphoma are not fully understood. <h3>Objectives</h3> The aim our study to use microarray gene expression data from well-defined cohort pSS patients identify relevant lymphoma. <h3>Methods</h3> and healthy controls UK primary registry (UKPSSR) were used this study. All fulfilled AECG criteria. Whole genome whole...
<h3>Background</h3> Local and systemic activation of interferons (IFNs) has been demonstrated in primary Sjögren9s syndrome (pSS).[1–4] Type I IFNs are associated with higher disease activity autoantibody levels.[5] Recent findings also show interferon type II (IFNγ) induced gene expression salivary glands pSS patients.[6, 7] Although IFN bind to different receptors they induce partially overlapping patterns. Understanding the relative contribution may deepen our knowledge pathogenesis...