A5027152672- Immunotherapy and Immune Responses
- Salivary Gland Disorders and Functions
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Diabetes and associated disorders
- RNA Interference and Gene Delivery
- Systemic Lupus Erythematosus Research
- Psoriasis: Treatment and Pathogenesis
- Immune Response and Inflammation
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Chronic Myeloid Leukemia Treatments
- Dermatology and Skin Diseases
- Monoclonal and Polyclonal Antibodies Research
- CAR-T cell therapy research
- Eosinophilic Disorders and Syndromes
- Chemokine receptors and signaling
- Chronic Lymphocytic Leukemia Research
- Peroxisome Proliferator-Activated Receptors
- Ocular Surface and Contact Lens
- Galectins and Cancer Biology
- Mast cells and histamine
- Polyomavirus and related diseases
- Inflammasome and immune disorders
- Wnt/β-catenin signaling in development and cancer
University of Bergen
2016-2025
Stavanger University Hospital
2024
Hudson Institute
2018-2020
John Wiley & Sons (United States)
2018-2020
Uppsala University
2015
Sapienza University of Rome
2015
Haukeland University Hospital
2009
University of Tübingen
2003-2007
Max Delbrück Center
2001-2002
University of Regensburg
2001
Dendritic cells (DC) are professional antigen-presenting that capable of both activating immune responses and inducing tolerance. Several studies have revealed efficiency therapeutic vaccination with tolerogenic DC (tolDC) in inhibition experimental autoimmunity. The purpose this study was to compare four different protocols for generation tolDC - the antidiabetic drug troglitazone (TGZ DC), NF-κB inhibitor BAY 11-7082 (BAY prostaglandin D2 metabolite 15d-PGJ2 (PGJ DC) a combination...
Cellular therapies with CD4+ T regulatory cells (Tregs) hold promise of efficacious treatment for the variety autoimmune and allergic diseases as well post-transplant complications. Nevertheless, current manufacturing Tregs a cellular medicinal product varies between different laboratories, which in turn hampers precise comparisons results studies performed. While number clinical trials testing is already substantial, it seems to be crucial provide some standardised characteristics Treg...
Cellular therapies with tolerogenic antigen-presenting cells (tolAPC) show great promise for the treatment of autoimmune diseases and prevention destructive immune responses after transplantation. The methodologies generating tolAPC vary greatly between different laboratories, making it difficult to compare data from studies; thus constituting a major hurdle development standardised therapeutic products. Here we describe an initiative by members field generate minimum information model...
Primary Sjögren's syndrome (SS) is the second most frequent systemic autoimmune disease, affecting 0.1% of general population. To characterize molecular and clinical variabilities among patients with primary SS, we integrated transcriptomic, proteomic, cellular, genetic data phenotypes in a cohort 351 SS.We analyzed blood transcriptomes genotypes SS who were participants multicenter prospective cohort. We replicated transcriptome analysis 3 independent cohorts (n = 462 patients). determined...
Abstract Dendritic cells are the most powerful antigen-presenting playing a decisive role for initiation and maintenance of primary immune responses. However, signaling pathways involved in differentiation these have not been fully determined. Imatinib is novel tyrosine kinase inhibitor effective against Abl kinases, c-Kit, platelet-derived growth factor receptor. Using this compound, we show that human monocyte-derived dendritic generated presence therapeutic concentrations imatinib reduced...
Phosphoflow cytometry is increasingly being used as a tool for the discovery of biomarkers in treatment and monitoring disease therapy. The ability to measure numerous phospho-protein targets simultaneously at single cell level accurately rapidly provides significant advantages over other methods. We here discuss important considerations required successfully implement these Three different blood collection tubes (lithium-heparin tubes, CPT with sodium citrate heparin) were evaluated, PBMC...
Immune-mediated lipodystrophy syndromes are rare autoimmune disorders characterized by complete or partial destruction of adipocytes in the body. Recently, autoantibodies against perilipin-1 (PLIN1-autoAbs) have been linked to lipodystrophy. Since various perilipins expressed adrenal cortex and ovaries, we asked whether PLIN1-autoAbs were present patients with dysfunction other endocrinopathies. Using a sensitive radiobinding immune assay analyzed anti-PLIN1-autoAbs 521 endocrinopathies...
Abstract Identification of tumor-associated antigens and advances in tumor immunology resulted the development vaccination strategies to treat patients with malignant diseases. Using a novel approach that combines DNA chip analysis samples isolation peptides on surface cells, HLA-A*0201-binding peptide derived from adipophilin protein was identified. Adipophilin is involved lipid storage thought be expressed only adipocytes, but it can found other cell types such as macrophages or cells. In...
This report describes the first study in humans with SDZ HTF 919 (HTF), a novel, selective 5‐hydroxytryptamine 4 (5‐HT ) receptor partial agonist and investigates its tolerability, pharmacokinetics, pharmacodynamics. Three cohorts of 12 men, whom 8 were treated active drug placebo, participated double‐blind, randomized, parallel‐group, ascending‐dose study. A single dose subsequently twice‐daily multiple doses 25, 50, 100 mg given for 14 days. Adverse events, clinical laboratory variables,...
Sjögren's syndrome (SS) is a lymphoproliferative autoimmune disease, characterised by dryness of the mouth and eyes. Dendritic cells (DC) are potent antigen-presenting crucial for initiating maintaining primary immune responses. This study quantified interferon-producing plasmacytoid DC (pDC) two myeloid subsets (mDC1 mDC2) in peripheral blood (PB) from SS (pSS) patients healthy controls.Blood samples 31 pSS 28 gender age-matched controls were analysed flow cytometry using Miltenyi Blood...
Primary Sjögren's syndrome (pSS) is a chronic, inflammatory autoimmune disease characterised by lymphocytic infiltrations in the exocrine glands, resulting destruction of salivary and lacrimal glands. B cells have an important role disease, as detection autoantibodies against SSA/Ro or SSB/La one diagnostic criteria, being found majority patients. Toll-like receptors (TLR) are pattern recognition receptors. TLR-7 -9 endosomes bind microbial nucleic acids. We previously shown that pSS...
Primary Sjögren's syndrome (pSS) is associated with polymorphisms and mRNA expression profiles that are indicative of an exaggerated innate type I IFN immune response. Excessive activation potential signaling pathways may play a role in this profile, but the intracellular profile disease not well characterized. To gain insights into potentially dysfunctional pSS patients we conducted exploratory analysis MAPK/ERK JAK/STAT networks peripheral blood mononuclear cells (PBMC) from 25 female...