A5073428024- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Diabetes and associated disorders
- Immunotherapy and Immune Responses
- Pancreatic function and diabetes
- Diabetes Management and Research
- CAR-T cell therapy research
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Hematopoietic Stem Cell Transplantation
- RNA regulation and disease
- Genomics, phytochemicals, and oxidative stress
- CRISPR and Genetic Engineering
- Advanced Proteomics Techniques and Applications
- Renal Transplantation Outcomes and Treatments
- Phagocytosis and Immune Regulation
- Apelin-related biomedical research
- Gestational Diabetes Research and Management
- Reproductive System and Pregnancy
- Angiogenesis and VEGF in Cancer
- Nutrition and Health Studies
- interferon and immune responses
- Cardiovascular Disease and Adiposity
- Protein Tyrosine Phosphatases
- Dermatological diseases and infestations
Gdańsk Medical University
2016-2025
University of Gdańsk
2019-2025
Warsaw University of Life Sciences
2024
Inserm
2022
Jagiellonian University
2012-2021
ZRE Gdańsk (Poland)
2020
Weatherford College
2013
Pontifical University of John Paul II in Kraków
2012
University of Chicago
2011
Type 1 diabetes is a condition in which pancreatic islets are destroyed by self-reactive T cells. The process facilitated deficits the number and suppressive activity of regulatory cells (Tregs). Here, we show for first time that infusion autologous Tregs prolongs remission recently diagnosed type children.We have administered 10 diabetic children (aged 8-16 years) within 2 months since diagnosis. In total, 4 patients received × 10(6) Tregs/kg body wt, remaining 6 20 wt. preparation...
Syrian hamsters were shown to be susceptible infection by the Lyme disease spirochete Borrelia burgdorferi. Although these spirochetes did not cause any outward signs of illness in animals, they a generalized infection. Spirochetemia was present during first 6 days At 14 postinfection, could isolated from one or more following organs: spleen, eyes, kidneys, liver, testes, and brain. Spirochetes eyes kidneys animal 52 suggesting that organisms may persistent Virulence B. burgdorferi is...
Recent studies suggest that immunotherapy using T regulatory cells (Tregs) prolongs remission in type 1 diabetes (T1DM). Here, we report factors possibly affect the efficacy of this treatment.The metabolic and immune background 12 children with recently diagnosed T1DM, as well untreated subjects, during a 2-year follow-up is presented. Patients were treated up to 30 × 106/kg b.w. autologous expanded CD3+CD4+CD25highCD127- Tregs.The disease progressed all patients insulin-dependent 2 years...
Abstract Cell-based immunotherapies can provide safe and effective treatments for various disorders including autoimmunity, cancer, excessive proinflammatory events in sepsis or viral infections. However, to achieve this goal there is a need deeper understanding of mechanisms the intercellular interactions. Regulatory T cells (Tregs) are lymphocyte subset that maintain peripheral tolerance, whilst mesenchymal stem (MSCs) multipotent nonhematopoietic progenitor cells. Despite coming from...
Cellular therapies with CD4+ T regulatory cells (Tregs) hold promise of efficacious treatment for the variety autoimmune and allergic diseases as well post-transplant complications. Nevertheless, current manufacturing Tregs a cellular medicinal product varies between different laboratories, which in turn hampers precise comparisons results studies performed. While number clinical trials testing is already substantial, it seems to be crucial provide some standardised characteristics Treg...
Ex vivo expanded CD4(+)CD25(high)CD127(-) T regulatory cells (Tregs) are recognized as a promising candidate for immunosuppressive therapy in humans. However, due to the plasticity of Tregs lineage and artificial environment present during ex expansion, easily lose suppressive activity. Here, we followed expanding their naive (CD45RA(+)) memory-like (CD45RA(-)) subsets order establish best conditions expansion. We found that, regardless phenotype sorted, were undergoing changes resembling...
Adoptive therapy with regulatory T cells or tolerance-inducing antigen presenting are innovative and promising therapeutic approaches to control undesired harmful activation of the immune system, as observed in autoimmune diseases, solid organ bone marrow transplantation. One critical issues elucidate mechanisms responsible for success failure these therapies define specificity is evaluation (Ag)-specific cell responses. Several efforts have been made develop suitable reproducible assays....
Objective Hypertension is the most common cardiovascular disease and main risk factor for stroke, peripheral arterial disease, aneurysms kidney disease. It has been reported recently that hypertensive patients animals are characterized by decreased density of arterioles capillaries in tissues, called rarefaction. Rarefaction significantly increases resistance which results elevated blood pressure, leads to vessel damage induction inflammation. Therefore, we hypothesized hypertension...
The hallmark of preeclampsia (PE) is a shift toward persistent inflammatory response, accompanied by endothelial dysfunction. driving forces in PE are proinflammatory cytokine and growth factors, parallel with reduced functionality anti-inflammatory effectors, like regulatory T cells observed. Unfortunately, no conclusive mechanism underlying has been identified. For this reason, research on needed to provide state the art understanding pathophysiology, identification new diagnostics tools...
Tolerance to foetal tissues in pregnancy depends on the match between mother and child. CD4+Foxp3+ regulatory T cells (Tregs), which are involved peripheral tolerance, may facilitate this effect. Previous findings have indicated that number of missing KIR ligands (MSLs) child correlates with risk gestational hypertension (GH) preeclampsia (PE). This study tested whether Tregs pathogenesis disorders. In total, 57 pregnant women participated, including 39 hypertensive disorders 18 healthy...
Sjögren’s syndrome is an autoimmune disease characterized by lymphatic infiltration of secretory tissues. The results in dryness the eyeball or mouth, which often occur simultaneously. Agents used to treat may improve oral hydration and patient’s quality life. There are several pharmacological non-pharmacological agents significant problem like xerostomia. use appropriate medicines (i.e. pilocarpine cevimeline) cause changes local microbiome, very sensitive quantitative water. As a result...
In Brief Objectives: To develop a novel approach for local immunoprotection using CD4+CD25highCD127– T regulatory cells (Tregs) attached to the surface of islets before transplantation. Background: Tregs expanded ex vivo can control allo and autoreactivity, therefore, Treg-based therapy may offer more effective protection transplanted from immunologic attack than currently used immunosuppression. Local application make such clinically feasible efficient. Methods: Human were isolated coated...