A5030406939- Probiotics and Fermented Foods
- Pediatric health and respiratory diseases
- Gut microbiota and health
- Pregnancy and preeclampsia studies
- Antimicrobial Peptides and Activities
- Enzyme Production and Characterization
- Nanoparticle-Based Drug Delivery
- Iron oxide chemistry and applications
- Reproductive System and Pregnancy
- Inflammatory Bowel Disease
- Respiratory and Cough-Related Research
- Inflammasome and immune disorders
- Nanoparticles: synthesis and applications
- Vascular anomalies and interventions
- Cardiac Arrhythmias and Treatments
- Pharmaceutical and Antibiotic Environmental Impacts
- Immune Response and Inflammation
- Gestational Diabetes Research and Management
- Intracranial Aneurysms: Treatment and Complications
- Vascular Malformations Diagnosis and Treatment
- Aquaculture disease management and microbiota
- Immunotherapy and Immune Responses
- Prenatal Screening and Diagnostics
- Gastrointestinal motility and disorders
- Microbial Metabolites in Food Biotechnology
Ludwik Hirszfeld Institute of Immunology and Experimental Therapy
2020-2024
Polish Academy of Sciences
2020-2024
Gdańsk Medical University
2018-2023
The hallmark of preeclampsia (PE) is a shift toward persistent inflammatory response, accompanied by endothelial dysfunction. driving forces in PE are proinflammatory cytokine and growth factors, parallel with reduced functionality anti-inflammatory effectors, like regulatory T cells observed. Unfortunately, no conclusive mechanism underlying has been identified. For this reason, research on needed to provide state the art understanding pathophysiology, identification new diagnostics tools...
Bifidobacteria are among the most common bacteria used for their probiotic properties and impact on maturation function of immune system has been well-described. Recently, scientific interest is shifting from live to defined bacteria-derived biologically active molecules. Their greatest advantage over probiotics structure effect independent viability status bacteria. Here, we aim characterize Bifidobacterium adolescentis CCDM 368 surface antigens that include polysaccharides (PSs),...
Abstract Bifidobacterium species are one of the most important probiotic microorganisms which present in both, infants and adults. Nowadays, growing data describing their healthy properties arise, indicating they could act at cellular molecular level. However, still little is known about specific mechanisms promoting beneficial effects. Nitric oxide (NO), produced by inducible nitric synthase (iNOS), involved protective gastrointestinal tract, where it can be provided epithelial cells,...
Abstract Background The impact of probiotic strains on host health is widely known. available studies the interaction between bacteria and are focused changes induced by in mainly. determining that occurred cells minority. Within this paper, we determined what happens to selected Bifidobacterium adolescentis longum ssp. an experimental environment with intestinal epithelial layer. For purpose, tested cells' viability, redox activity, membrane potential enzymatic activity different...
The activity of natural killer (NK) cells is considered an important factor for the tolerance fetus during pregnancy. complications pregnancy, such as hypertensive disorders (HDP), may be therefore associated with this immune compartment. current study included 41 pregnant women diagnosed HDPs (Gestational Hypertension; GH or Preeclampsia; PE) and 21 healthy women. All patients were under continuous obstetric care pregnancy labour. number mother-child mismatches within immunoglobulin-like...
Ageing is accompanied by the inevitable changes in function of immune system. It provides increased susceptibility to chronic infections that have a negative impact on quality life older people. Therefore, rejuvenating aged immunity has become an important research and therapeutic goal. Yolkin, polypeptide complex isolated from hen egg yolks, possesses immunoregulatory neuroprotective activity. Considering macrophages play key role pathogen recognition antigen presentation, we evaluated...
Prokaryotic polysaccharides, from peptidoglycan (PG) to external polysaccharides such as lipopolysaccharides or glycosphingolipids, represent available and abundant targets for magnetically capture of microorganisms. Surface active maghemite nanoparticles (SAMNs), are bare magnetic displaying high colloidal stability well selectivity toward several biomolecules. Herein, the remarkable chemical affinity between SAMNs Listeria spp PG., used model microganism, was extensively demonstrated...
Abstract Allergies have become a growing problem and the number of cases is increasing yearly. Administration postbiotics, well-defined bacterial molecules, gaining attention as novel promising strategy to ameliorate allergic burden. The BAP1 polysaccharide (PS) Bifidobacterium adolescentis CCDM 368, was previously characterized by us regarding its structure in vitro immunomodulatory properties. Here, decipher effect on immune system development, it intranasally (i.n.) administered germ-free...
Preeclampsia is responsible for more than 70 000 and 500 maternal fetal deaths, respectively each year. Incomplete remodelling of the spiral arteries in placenta most accepted theory preeclampsia pathogenesis. However, process complexed with immunological background, as pregnancy resembles allograft transplantation. Fetus expresses human leukocyte antigens (HLA) inherited from both parents, thus semiallogeneic to immune system. Therefore, induction tolerance crucial physiological outcome...
Prokaryotic polysaccharides, from peptidoglycan (PG) to external polysaccharides such as lipopolysaccharides or glycosphingolipids, represent available and abundant targets for magnetically capture of microorganisms. Surface active maghemite nanoparticles (SAMNs), are bare magnetic displaying high colloidal stability well selectivity toward several biomolecules. Herein, the remarkable chemical affinity between SAMNs Listeria spp PG., used model microganism, was extensively demonstrated...
Authors report the case of cardiomegaly associated with vein Galen aneurysmal malformation.Prenatal diagnosis this anomaly enables plan delivery and treatment in special neurosurgical department.