A5026729333- Animal Nutrition and Physiology
- Antimicrobial Peptides and Activities
- Immune Response and Inflammation
- Protein Hydrolysis and Bioactive Peptides
- Biochemical effects in animals
- Nerve injury and regeneration
- Glioma Diagnosis and Treatment
- Nuclear Structure and Function
- Animal health and immunology
- Carbon and Quantum Dots Applications
- Autism Spectrum Disorder Research
- Meat and Animal Product Quality
- Immunotherapy and Immune Responses
- Neuropeptides and Animal Physiology
- Aquaculture Nutrition and Growth
- Animal Genetics and Reproduction
- Transgenic Plants and Applications
- Genomics and Chromatin Dynamics
- Ubiquitin and proteasome pathways
- Nanocluster Synthesis and Applications
- Gut microbiota and health
- Immune Cell Function and Interaction
- Histone Deacetylase Inhibitors Research
- Probiotics and Fermented Foods
- Virus-based gene therapy research
Ludwik Hirszfeld Institute of Immunology and Experimental Therapy
2019-2024
Polish Academy of Sciences
2019-2024
Wrocław University of Science and Technology
2019
AGH University of Krakow
2019
Food-derived bioactive peptides able to regulate neuronal function have been intensively searched and studied for their potential therapeutic application. Our previous study showed that a polypeptide complex yolkin, isolated from hen egg yolk as fraction accompanying immunoglobulin Y (IgY), improved memory cognitive functions in rats. However, the mechanism activated by yolkin is not explained. The goal of present was examine what molecular regulating brain-derived neurotrophic factor (BDNF)...
One of the goals biomedical sciences is to search and identify natural compounds that are safe, have no side effects, possess immunostimulatory activity. It has been proven medicines origin can be effective agents, supporting therapy many diseases, not only in weakened immune system body but also prevention diseases healthy people. shown yolkin, a polypeptide complex isolated from hen egg yolk as fraction accompanying immunoglobulin Y (IgY), possesses potential biological However, mechanism...
Abstract Transcription factor 4 (TCF4) is a class I basic helix-loop-helix (bHLH) transcription which regulates the neurogenesis and specialization of cells. TCF4 also plays an important role in development functioning immune system. Additionally, Sertoli cells pontine nucleus neurons, myogenesis, melanogenesis epithelial-mesenchymal transition. The ability factors to fulfil their function often depends on intracellular trafficking between cytoplasm cell. regulated by specific sequences,...
Abstract Background The impact of probiotic strains on host health is widely known. available studies the interaction between bacteria and are focused changes induced by in mainly. determining that occurred cells minority. Within this paper, we determined what happens to selected Bifidobacterium adolescentis longum ssp. an experimental environment with intestinal epithelial layer. For purpose, tested cells' viability, redox activity, membrane potential enzymatic activity different...
Nutraceuticals can reduce the risk of many diseases, such as cardiovascular disease, immune deficiencies, neurodegeneration, and others. Their delivery remains a challenge because it depends on factors, most notably stability bioactive compounds. Yolkin is peptide complex isolated from hen egg yolk with immunomodulatory neuroprotective potential. However, yolkin relatively poorly characterized. We aimed to determine origin glycosylation level yolkin, its storage conditions, thermal...
Ageing is accompanied by the inevitable changes in function of immune system. It provides increased susceptibility to chronic infections that have a negative impact on quality life older people. Therefore, rejuvenating aged immunity has become an important research and therapeutic goal. Yolkin, polypeptide complex isolated from hen egg yolks, possesses immunoregulatory neuroprotective activity. Considering macrophages play key role pathogen recognition antigen presentation, we evaluated...
The need for efficient probing, sensing, and control of the bioactivity biomolecules (e.g., albumins) has led to engineering new fluorescent albumins' markers fulfilling very specific chemical, physical, biological requirements. Here, we explore acetone-derived polymer dots (PDs) as promising candidates albumin probes, with special attention paid their cytocompatibility, two-photon absorption properties, strong ability non-destructively interact serum albumins. PDs show no cytotoxicity...
Abstract The results of our research have proven that yolkin preparations isolated from eggs different bird species show a high similarity in polypeptide composition. Despite the small differences protein patterns, all showed also strong immunomodulatory activity, comparable with obtained previously hen egg yolk. It can therefore be deducted presence this complex is not accidental and performs an important biological function for developing embryo.
Abstract The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have already infected more than 0.7 billion people and caused over 7 million deaths worldwide. At the same time, our knowledge about this virus is still incipient. In some cases, there a pre-pandemic immunity, however its source unknown. analysis of patients’ humoral responses might shed light on puzzle. paper, we evaluated antibody recognition nucleocapsid protein, one structural proteins SARS-CoV-2. For purpose, used...
Brain-derived neurotrophic factor (BDNF) plays an important role in the proper functioning of nervous system. It regulates growth and survival nerve cells, is crucial processes related to memory, learning synaptic plasticity. Abnormalities distribution secretion BDNF protein accompany many diseases system, course which a significant decrease level brain observed. Impairments transport may occur, for example, event single nucleotide polymorphism Bdnf (Val66Met) coding gene or due dysfunctions...