A5037230152- Glycosylation and Glycoproteins Research
- Carbohydrate Chemistry and Synthesis
- Probiotics and Fermented Foods
- Advanced Glycation End Products research
- Immune Response and Inflammation
- Escherichia coli research studies
- Genomics and Phylogenetic Studies
- Bacteriophages and microbial interactions
- Polysaccharides and Plant Cell Walls
- Microbial Metabolites in Food Biotechnology
- Mycobacterium research and diagnosis
- Antimicrobial Peptides and Activities
- Bacterial Infections and Vaccines
- Monoclonal and Polyclonal Antibodies Research
- Actinomycetales infections and treatment
- Viral gastroenteritis research and epidemiology
- Pneumonia and Respiratory Infections
- S100 Proteins and Annexins
- Alcohol Consumption and Health Effects
- Gut microbiota and health
- Bacterial Genetics and Biotechnology
- Cancer Research and Treatments
- Advanced Biosensing Techniques and Applications
- Metabolism, Diabetes, and Cancer
- Pediatric health and respiratory diseases
Ludwik Hirszfeld Institute of Immunology and Experimental Therapy
2016-2025
Polish Academy of Sciences
2016-2025
National Institute of Standards and Technology
2023
Université de Lorraine
2023
Wroclaw Medical University
2012-2021
Wroclaw Research Centre EIT+ (Poland)
2010-2021
Institute of Immunology
2006-2020
Central Clinical Hospital
2020
Ministry of Interior and Administration
2020
University of Wrocław
2007-2017
Phenols are the most abundant compounds in nature. They strong antioxidants. Too high level of free radicals leads to cell and tissue damage, which may cause asthma, Alzheimer disease, cancers, etc. Taking phenolics with diet as supplements or natural medicines is important for homeostasis organism.The ten popular water soluble phenols were chosen experiment investigate their antioxidant properties using ABTS radical scavenging capacity assay ferric reducing potential (FRAP)...
Glycation is a non-enzymatic process involving the reaction of reducing sugars or reactive oxoaldehyde with proteins, lipids nucleic acids, which results in formation advanced glycation end products (AGEs). The presented work discusses people stage type 1 2 diabetes. concentration different AGEs and their receptors for 58 serum samples was determined by ELISA spectrofluorimetric methods. In addition to fluorescent low molecular weight protein-bound AGEs, we have also marked new class AGEs:...
Glycation is a physiological process that determines the aging of organism, while in states metabolic disorders it significantly intensified. High concentrations compounds such as reducing sugars or reactive aldehydes derived from lipid oxidation, occurring for example diabetes, atherosclerosis, dyslipidemia, obesity syndrome, lead to increased glycation proteins, lipids and nucleic acids. The level advanced end-products (AGEs) body depends on rapidity their production rate removal by...
Abstract Conjugation of the group B meningococcal polysaccharide to tetanus toxoid failed substantially enhance its immunogenicity in mice. Therefore, additional chemical manipulation basic structure was attempted, on premise that a synthetically derived artificial antigen might be capable modulating immune response mice produce elevated levels cross-reactive polysaccharide-specific antibodies. To achieve this, antigenicity modified antibodies had preserved, and this criterion could only...
The ability to produce exopolysaccharides (EPS) is widespread among lactobacilli including Lactobacillus rhamnosus, the commonly used probiotic bacteria. Exopolysaccharides are a major component of bacterial biofilm with well-documented impact on adherence bacteria host cells. However, their immunoregulatory properties unknown. aim this study was examine immunostimulatory potential EPS derived from L. rhamnosus KL37. We investigated effect production inflammatory mediators by mouse...
Abstract L-Arginine/NO pathway is altered in Alzheimer disease (AD). Its clinical relevance and status vascular dementia (VaD) are unknown. Using targeted metabolomics (a liquid chromatography-mass spectrometry) we assessed L-arginine, L-citrulline, dimethylamine (DMA), asymmetric dimethyl arginine (ADMA) symmetric dimethylarginine (SDMA) AD (n = 48), mixed-type (MD; n 34), VaD 40) non-demented individuals 140) determined their (the association with pathology, cognitive impairment,...
Microbiome alterations are emerging as one of the most important factors that influence course alcohol use disorder (AUD). Recent advances in bioinformatics enable more robust and accurate characterization changes composition microbiome. In this study, our objective was to provide comprehensive up-to-date evaluation microbiome associated with AUD alcoholic liver disease (ALD). To achieve it, we have applied consistent, state art bioinformatic workflow raw reads from multiple 16S rRNA...
Three different oligosaccharides were isolated by mild acid hydrolysis of the lipopolysaccharides, obtained from Neisseria meningitidis serotype 5, and their structures elucidated combined chemical physical techniques. The use 500-MHz 1H NMR in both one-dimensional two-dimensional modes as well nuclear Overhauser effect experiments employed. To assist structural assignments purified also degraded enzymatic procedures to smaller fragments. largest three original is a triantennary partially...
Background: Accurate outcome prediction in gastroesophageal malignancies is challenging. Acute-phase response proteins (APRPs) have been claimed to be independent prognosticators, although the basis for their association with prognosis remains unexplained. We hypothesized that, similarly pancreatic and lung cancers, changes APRPs are associated cachexia accelerated angiogenesis.
Matrix metalloproteinase- (MMP-) 9 is one of the main metalloproteinases reported to be involved in extracellular matrix degradation and recently also triggering angiogenic switch course inflammatory bowel diseases (IBD). The goal our studies was estimate experimental setting levels MMP-9 sera Crohn’s Disease (CD) ulcerative colitis (UC) patients evaluate its possible diagnostic potential comparison with other biochemical markers selected proinflammatory factors. study group included 176...
Staphylococcus is one of the most frequently isolated genera opportunistic bacteria in animals and human beings. Staphylococci mammals mostly inhabit skin mucous membranes. The objectives study were to investigate distribution staphylococcal species healthy sick cats order find diagnostic markers. risk factors associated with colonization also explored. Isolates from (n=520) (n=67) identified at level using matrix-assisted laser desorption ionization time flight mass spectrometry (MALDI-TOF...
Polyphenolic compounds are now widely studied using computational chemistry approaches, the most popular of which is Density Functional Theory. To ease this process, it critical to identify optimal level theory in terms both accuracy and resource usage—a challenge we tackle study. Eleven DFT functionals with varied Hartree–Fock exchange values, global range-separated hybrids, were combined 14 differently augmented basis sets calculate reactivity indices caffeic acid, a phenolic acid...