A5069918733- Escherichia coli research studies
- Salmonella and Campylobacter epidemiology
- Viral gastroenteritis research and epidemiology
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Yersinia bacterium, plague, ectoparasites research
- T-cell and B-cell Immunology
- Tuberculosis Research and Epidemiology
- Antibiotic Resistance in Bacteria
- Immune cells in cancer
- Listeria monocytogenes in Food Safety
- Monoclonal and Polyclonal Antibodies Research
- RNA and protein synthesis mechanisms
- Food Safety and Hygiene
- Clostridium difficile and Clostridium perfringens research
- Hepatitis Viruses Studies and Epidemiology
- Bacterial Genetics and Biotechnology
Israel Ministry of Health
2016-2024
Hebrew University of Jerusalem
2001-2006
Abstract T cell AgR ζ chain down-regulation associated with dysfunction has been described in cancer, infectious, and autoimmune diseases. We have previously shown that chronic inflammation is mandatory for the induction of an immunosuppressive environment leading to this phenomenon. To identify key components, we used vivo mouse model exhibiting inflammation-induced immunosuppression. Herein, demonstrate that: 1) under secondary lymphatic organs display various immunological milieus; are...
Background Shigella is a leading cause of moderate-to-severe diarrhoea worldwide and diarrhoeal deaths in children low- and-middle-income countries. Aim We investigated trends characteristics shigellosis antimicrobial resistance sonnei Israel. Methods analysed data generated by the Sentinel Laboratory-Based Surveillance Network for Enteric Pathogens that systematically collects on detection at sentinel laboratories, along with characterisation isolates National Reference Laboratory. Trends...
Macrolides have been effective clinical antibiotics for over 70 years. They inhibit protein biosynthesis in bacterial pathogens by narrowing the nascent exit tunnel ribosome. The macrolide class of natural products consist a macrolactone ring linked to one or more sugar molecules. Most macrolides used currently are semi-synthetic erythromycin derivatives, composed 14- 15-membered ring. Rapidly emerging resistance is among most urgent global health challenges, which render many ineffective,...
Shigella species remains a major diarrhoeagenic agent, affecting mostly children, with global high incidence and mortality rate specially in developing areas. Although azithromycin is recommended for treatment of shigellosis, there are currently no CLSI susceptibility breakpoints, accordingly routine antimicrobial test performed the clinical laboratory. The purpose this study was to estimate prevalence, resistance profile molecular epidemiology non-susceptible strains Israel during three...
This study analyses the epidemiologic, clinical and molecular findings of all culture-confirmed cases listeriosis notified from 2010 to 2015 in Tel Aviv District, which is known have high rates listeriosis. All isolates Listeria monocytogenes were subtyped using two-enzyme pulsed-field gel electrophoresis. During studied period, 102 notified, including 23 pregnancy-associated (23%). Among 79 non-pregnancy-associated cases, 18 had neuro-invasive disease (21%). There 26 deaths associated with...
Whole-genome sequencing unveiled host and environment-related insights to Shigella sonnei transmission within cyclic epidemics during 2000-2012 in Israel. The Israeli reservoir contains isolates belonging S. lineage III but of different origin, shows loss tetracycline resistance genes, little genetic variation the O antigen: highly relevant for vaccine development.
The TCR recognizes peptide-MHC complexes and transmits activation signals leading to cellular responses. We have previously characterized two populations expressed on the T cell surface; one is linked cytoskeleton via a detergent-insoluble cytoskeleton-associated ζ (cska-ζ) chain, while other detergent soluble not cytoskeleton. cska-ζ form displays unique properties: it constitutively phosphorylated, does undergo hyperphosphorylation upon stimulation as opposed its...