A5048840225- NF-κB Signaling Pathways
- Immune Response and Inflammation
- interferon and immune responses
- Phosphodiesterase function and regulation
- Advanced Glycation End Products research
- Nitric Oxide and Endothelin Effects
- Peptidase Inhibition and Analysis
- Protein Hydrolysis and Bioactive Peptides
- Neurogenesis and neuroplasticity mechanisms
- Nerve injury and regeneration
- Natural Antidiabetic Agents Studies
- Heart Failure Treatment and Management
- Receptor Mechanisms and Signaling
- Neuropeptides and Animal Physiology
- Immune Cell Function and Interaction
- Alzheimer's disease research and treatments
- Inflammatory mediators and NSAID effects
- Sesame and Sesamin Research
- Protease and Inhibitor Mechanisms
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Natural product bioactivities and synthesis
- Mast cells and histamine
- Ubiquitin and proteasome pathways
- Animal health and immunology
Polish Academy of Sciences
2006-2024
Ludwik Hirszfeld Institute of Immunology and Experimental Therapy
2006-2024
The induction of β-interferon (IFN-β) is a key anti-viral response to infection by RNA viruses. Virus-induced expression IFN-β requires the co-operative action transcription factors IRF-3/7, NF-κB, and ATF-2/c-Jun on promoter leading orderly recruitment chromatin remodeling complexes. Although viruses strongly activate NF-κB promote its binding promoter, recent studies have indicated that not essential for virus-induced IFN-β. Herein, we examined role in regulating viral-sensing Toll-like...
Innate immune response is a universal mechanism against invading pathogens. Toll-like receptors (TLRs), being part of first line defense, are responsible for detecting variety microorganisms. Among them TLR9, which localized in endosomes, acts as sensor unmethylated CpG motifs present bacteria, DNA viruses (e.g., HSV-1), or fungi. TLRs differ from one another by the use accessory proteins. MyD88 adapter-like (Mal) adapter molecule considered positive regulator TLR2- and TLR4-dependent...
One of the goals biomedical sciences is to search and identify natural compounds that are safe, have no side effects, possess immunostimulatory activity. It has been proven medicines origin can be effective agents, supporting therapy many diseases, not only in weakened immune system body but also prevention diseases healthy people. shown yolkin, a polypeptide complex isolated from hen egg yolk as fraction accompanying immunoglobulin Y (IgY), possesses potential biological However, mechanism...
Advanced glycation end-products (AGEs) are capable of stimulating oxidative stress and inflammation. This study investigates the synthesis medium crosslinked AGEs (the most optimal form because soluble in water, used many assays as markers) their biochemical properties.
Neurotrophins such as nerve growth factor (NGF) and brain-derived neurotrophic factor, well cytokines, for example, interleukin-6 (IL-6) play an important role in neuroprotection the control of central nervous system (CNS) function. Reduced expression factors can lead to dysregulation neuron function neuronal death. There is also evidence mutual interactions between neurotrophins IL-6. Therefore, up-regulating level neuroprotective substances one key manners development It be a promising aim...
Colostral proline-rich polypeptide complex (PRP) with immunoregulatory and procognitive activities shows beneficial effects in Alzheimer's disease (AD). As the laboratory method of isolating PRP is expensive, laborious, time consuming, a new large-scale methanol isolation was developed. The obtained by this (named PRP–MPRP) from both ovine or bovine colostra psychotropic activity inhibitory effect on amyloid β aggregation similar to those produced laboratory-scale method. comparative study...
Activation of TLR7 by small imidazoquinoline molecules such as R848 or R837 initiates signaling cascades leading to the activation transcription factors, AP-1, NF-κB, and interferon regulatory factors (IRFs) afterward induction cytokines anti-viral Type I IFNs. In general, TLRs mediate these effects utilizing different intracellular molecules, one them is Mal. Mal a protein closely related antibacterial response, its role in pathways remains poorly understood. this study, we show that...
Cyclic guanosine monophosphate (cGMP) is synthesized by two types of enzymes: particulate (membrane-bound) guanylyl cyclases (pGCs) and soluble (cytosolic) (sGCs). sGCs are activated primarily binding nitric oxide to their prosthetic heme group while pGCs peptide ligands extracellular domains. One them, pGC type A (GC-A) atrial brain natriuretic peptides (ANP BNP, respectively). Human monocytes isolated from peripheral blood mononuclear cells have been shown sGC expression without...