A5000954445- Parasitic Diseases Research and Treatment
- Parasites and Host Interactions
- Parasite Biology and Host Interactions
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Helminth infection and control
- Parasitic infections in humans and animals
- Vector-borne infectious diseases
- Insects and Parasite Interactions
- CAR-T cell therapy research
- Enterobacteriaceae and Cronobacter Research
- Immune Cell Function and Interaction
- Parasitic Infections and Diagnostics
- Mast cells and histamine
- Planarian Biology and Electrostimulation
- Extracellular vesicles in disease
- Complement system in diseases
- Vector-Borne Animal Diseases
- Antifungal resistance and susceptibility
- Glycosylation and Glycoproteins Research
- Animal testing and alternatives
- Monoclonal and Polyclonal Antibodies Research
- Viral Infectious Diseases and Gene Expression in Insects
- Vagus Nerve Stimulation Research
- Forensic Entomology and Diptera Studies
University of Belgrade
2015-2025
Institute for the Application of Nuclear Energy
2003-2022
Institute of Economic Sciences
2008
École Nationale Vétérinaire d'Alfort
2002
Bipar
2002
HUN-REN Institute for Nuclear Research
2001
Abstract Trichinella infection results in formation of a capsule infected muscles. The is residence the parasite which composed nurse cell and fibrous wall. process complex includes muscle response (de-differentiation, cycle re-entry arrest) satellite responses (activation, proliferation differentiation). Some events that occur during are analogous to those occurring regeneration/repair. This article reviews with emphasis on this analogy.
Trichinella spiralis is a helminth that provokes Th2 and anti-inflammatory type responses in an infected host. Our previous studies using Dark Agouti (DA) rats indicated T. infection reduced experimental autoimmune encephalomyelitis (EAE) severity rats. The aim of this study was to analyse the mechanisms underlying EAE suppression driven by infection. Reduced clinical histological manifestations disease were accompanied increased IL-4 IL-10 production decreased IFN-γ IL-17 draining lymph...
Trichinella spiralis, as well its muscle larvae excretory-secretory products (ES L1), given either alone or via dendritic cells (DCs), induce a tolerogenic immune microenvironment in inbred rodents and successfully ameliorate experimental autoimmune encephalomyelitis. ES L1 directs the immunological balance away from T helper (Th)1, toward Th2 regulatory responses by modulating DCs phenotype. The ultimate goal of our work is to find out if it possible translate knowledge obtained animal...
Cellular therapies with CD4+ T regulatory cells (Tregs) hold promise of efficacious treatment for the variety autoimmune and allergic diseases as well post-transplant complications. Nevertheless, current manufacturing Tregs a cellular medicinal product varies between different laboratories, which in turn hampers precise comparisons results studies performed. While number clinical trials testing is already substantial, it seems to be crucial provide some standardised characteristics Treg...
Cellular therapies with tolerogenic antigen-presenting cells (tolAPC) show great promise for the treatment of autoimmune diseases and prevention destructive immune responses after transplantation. The methodologies generating tolAPC vary greatly between different laboratories, making it difficult to compare data from studies; thus constituting a major hurdle development standardised therapeutic products. Here we describe an initiative by members field generate minimum information model...
Purpose: Trichinella spiralis has evolved complex immunomodulatory mechanisms mediated by excretory-secretory products (ESL1) that enable its survival in the host. Consequently, ESL1 antigens display excellent potential for treating autoimmune diseases such as multiple sclerosis (MS). However, whether timely controlled delivery of vivo, natural infections, could enhance therapeutic MS is still unknown. Methods: To test this, we encapsulated into biodegradable poly (lactide-co-glycolic) acid...
Summary Many parasitic helminth infections induce Th2‐type immune responses and engage the regulatory network. In this study, we specifically investigated influence of antigens derived from different life stages Trichinella spiralis on polarization naive CD4 + T cells by dendritic cells. Results obtained C57BL/6 mice showed that T. have capacity to bone marrow‐derived acquire an incompletely mature phenotype promotes a significant proliferation mixed Th1/Th2 cytokine profile with...
Macropathogens, such as multicellular helminths, are considered masters of immunoregulation due to their ability escape host defense and establish chronic infections. Molecular crosstalk between the parasite starts immediately after encounter, which influences course development both innate adaptive arms immune response. Helminths can modulate dendritic cells (DCs) function induce immunosuppression is mediated by a regulatory network that includes T (Treg) cells, B (Breg) alternatively...
Extracellular vesicles (EVs) represent a newly discovered but universal communication tool between cells or organisms. However, few data exist on nematode EVs and none for Trichinella spiralis. Here, we aimed to investigate whether T spiralis muscle larvae produce EVs, they carry immunomodulatory proteins have role in immunomodulation as component of excretory-secretory products (ES L1).EVs were enriched from conditioned medium larvae. Transmission electron microscopy images showed be 30-80...
SUMMARY Complex and variable glycoconjugates presented by parasitic nematodes during infection are very important in the host–parasite interplay. Predominantly carbohydrate‐rich antigens involved stimulation modulation of stage‐specific immune response host. The non‐specific innate system, however, acts as first line host defence against pathogens, before appearance antigen‐specific responses. functional entities system lectins that recognize surface ligands pathogens: mannan‐binding lectin...
SUMMARY Pathogen‐derived products have the capacity to induce maturation of bone marrow‐derived dendritic cells (BMDCs) into populations effectors that polarize Th toward Th1 or Th2 phenotype via different mechanisms. Since those mechanisms are not entirely clear for helminths, and almost completely unknown Trichinella spiralis (TS), we started an investigation effects TS antigens (four isolated from all three life‐cycle stages parasite) on BMDCs their potential present antigens. The...
Abstract In Europe, Serbia ranks among countries with a high prevalence of Trichinella infection in pigs, which continues to be serious human health problem. While some Balkan countries, more than one species/genotype has been described both the sylvatic and domestic cycles, these data are lacking for Serbia. To date, only few Serbian isolates have genetically specified, all were classified as T. spiralis. Although transmission from pigs wildlife could assumed, neither status nor species...
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Vasilev S, Ilic N, Gruden-Movsesijan A, Vasilijic Bosic M, Sofronic-Milosavljevic L. Experimental immunologyNecrosis and apoptosis in Trichinella spiralis-mediated tumour reduction. Central European Journal of Immunology. 2015;40(1):42-53. doi:10.5114/ceji.2015.50832. APA Vasilev, S., Ilic, N., Gruden-Movsesijan, A., Vasilijic, Bosic, M., & Sofronic-Milosavljevic, (2015). Immunology, 40(1), 42-53....
Trichinellosis is a rare parasitic zoonosis in the European Union. Meat from backyard pigs was common source for trichinellosis outbreak caused by Trichinella spiralis , which occurred France and Serbia beginning of 2017. An epidemiological study conducted to determine extent outbreak, identify its implement control measures. Three cases were exposed brought back pork delicatessen they shared with relatives friends. Around 47 individuals parasitised meat 20 reported (nine 11 Serbia). Nine...
Abstract Tolerogenic dendritic cells (tolDCs) are central players in the maintenance of immune tolerance and thereby have been identified as most favourable candidates for cell therapy autoimmune diseases. We recently shown that excretory-secretory products (ES L1) released by Trichinella spiralis larvae induce stable human tolDCs vitro via Toll-like receptor 2 (TLR2) TLR4. However, engagement these receptors did not fully explain tolerogenic profile DCs. Here, we observed first time...