A5066865633- Cancer and Skin Lesions
- Nonmelanoma Skin Cancer Studies
- Dermatological and COVID-19 studies
- Histiocytic Disorders and Treatments
- Hedgehog Signaling Pathway Studies
- Cutaneous Melanoma Detection and Management
- Renal and related cancers
- Cancer-related Molecular Pathways
- Cutaneous lymphoproliferative disorders research
- Infectious Diseases and Mycology
- Cancer-related gene regulation
- Cancer Research and Treatments
- Urticaria and Related Conditions
- Fungal Infections and Studies
- Virus-based gene therapy research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Gene expression and cancer classification
- Immunotherapy and Immune Responses
- Tumors and Oncological Cases
- Single-cell and spatial transcriptomics
- Plant Reproductive Biology
- Bone health and treatments
- SARS-CoV-2 and COVID-19 Research
- Skin and Cellular Biology Research
- Vasculitis and related conditions
Uppsala University
2022-2023
University of Belgrade
2015-2023
Institute of Physics Belgrade
2023
Science for Life Laboratory
2023
Michigan United
2020
IntroductionImmune cells in the tumour microenvironment are associated with prognosis and response to therapy. We aimed comprehensively characterise spatial immune phenotypes mutational clinicopathological background of non–small cell lung cancer (NSCLC).MethodsWe established a multiplexed fluorescence imaging pipeline spatially quantify 13 subsets 359 NSCLC cases: CD4 effector (CD4-Eff), regulatory (CD4-Treg), CD8 (CD8-Eff), (CD8-Treg), B-cells, natural killer cells, T-cells, M1 macrophages...
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Vasilev S, Ilic N, Gruden-Movsesijan A, Vasilijic Bosic M, Sofronic-Milosavljevic L. Experimental immunologyNecrosis and apoptosis in Trichinella spiralis-mediated tumour reduction. Central European Journal of Immunology. 2015;40(1):42-53. doi:10.5114/ceji.2015.50832. APA Vasilev, S., Ilic, N., Gruden-Movsesijan, A., Vasilijic, Bosic, M., & Sofronic-Milosavljevic, (2015). Immunology, 40(1), 42-53....
SUMMARY Genes with cell type specific expression typically encode for proteins that have functions. Single RNAseq (scRNAseq) has facilitated the identification of such genes, but various challenges limit analysis certain types and lowly expressed genes. Here, we performed an integrative network over 6000 bulk datasets from 15 human organs, to generate a tissue-by-tissue enrichment prediction atlas all protein coding We profile major constituent types, including several are fragile or...
Abstract Background Protein arginine methyltransferase-1 (PRMT1) is associated with the progression of various tumor types and process epithelial to mesenchymal transition (EMT). However, expression PRMT1 in renal cell tumors (RCT) unknown. Methods We evaluated immunohistochemical (IHC) on tissue microarray (TMA) 208 specimens RCT, including clear carcinomas (ccRCC), papillary RCC type I II (pRCC II), chromophobe (chRCC), oncocytomas (RO), collecting duct - Bellini (CDC) multilocular cystic...
Actinic keratosis (AK) and Bowen's disease (squamous cell carcinoma in situ, SCCIS) are pre-invasive stages the development of squamous (SCC).Immunohistochemical study cyclin D1, E, p16(INK4a) p21(Cip1) (/Waf1) AK (53 cases), SCCIS (16 cases) SCC (40 relation to type lesion prognostic parameters (grade, diameter thickness).Diffuse D1 distribution was more frequent than (p = 0.03) similar pattern observed for . For central dominated compared with 0.001) 0.03). displayed suprabasal frequently...
Linear IgA dermatosis (LAD) is a rare autoimmune disorder in children. A 9-year-old boy was presented with blisters on the intact skin (face, body, arms, hands, soles, perigenital and perianal area) after amoxicillin treatment. Systemic corticosteroids dapsone treatment for 6 weeks successful. Clinical immunofluorescence examinations are most important differentiation of LAD other drug-induced bullous dermatoses. They enable an early introduction proper therapy.
Minichromosome maintenance (MCM) proteins are a group of involved in DNA replication and cell-cycle regulation. Because they associated with through G1 into S phase, MCM potentially specific indicators cell proliferation that could be valuable markers dysplasia, preinvasive invasive malignant tumors. To analyze protein expression patterns actinic keratosis (AK), Bowen disease (BD), cutaneous squamous carcinoma (SCC), we performed immunohistochemical staining MCM2, -5, -7 on tissue microarray...
Citation: Dobrosavljevic D, Majstorovic J, Bosic M. Dermoscopy of generalized eruptive histiocytosis: case report and brief review the literature. Dermatol Pract Concept. 2020;10(3):e2020057. DOI: https://doi.org/10.5826/dpc.1003a57
Abstract Cutaneous lupus erythematosus (LE) encompasses a wide spectrum of dermatologic manifestations, including toxic epidermal necrolysis (TEN)-like presentations acute or subacute cutaneous (TEN-like ACLE/SCLE). Although the clinical characteristics and histological features these rare entities may closely mimic TEN, several subtle differences can help in differentiation between conditions. We report case patient with SCLE which developed drug unrelated TEN-like blisters after prolonged,...
We present a patient with 33-year history of poikilodermatous mycosis fungoides (MF) who subsequently developed CD30-positive large cell transformation. After 6 years conventional MF treatment, side effects therapy and/or concomitant diseases prevented the previously applied treatment modalities. The CD30-directed antibody-cytotoxic drug conjugate (brentuximab vedotin) was introduced and followed by quick excellent therapeutic response.
Abstract Basal cell carcinoma is the most common form of cutaneous cancer. In majority cases it locally invasive with slow growth, ranging in size from a couple milimeters to centimeters and located primarily on sun-exposed regions. Giant basal carcinoma, defined as tumor that larger than 5 cm diameter, very rare type malignancy accounting for 0.5-1% all carcinomas. We present case 74-year-old man 17 x 14 giant right supraclavicular region. Detailed history revealed lesion had started papule...
We present three new cases of cutaneous polyarteritis nodosa with a follow-up ranging from 38 to 49 months, describing their clinical and histological findings, as well treatment options leading sustained remission. All patients met the criteria for diagnosis. The presence extracutaneous symptoms laboratory analysis differed among our patients, did various elements workup in comparison published studies. concluded that dapsone alone, or combination systemic steroids, proved superior highly...
Introduction. Pfeifer?Weber?Christian disease (PWCD) is a rare inflammatory disorder of the subcutaneous fatty tissue. Angiolipoma, benign adipocytic soft tissue tumor composed mature adipose and small vascular proliferations. Treatment with corticosteroids could lead to proliferation fat but stimulation angiolipoma growth during corticosteroid therapy extremely rare. Case outline. We describe case 46-year-old female patient histopathological confirmation two diseases: PWCD multiple...
The sellar region is a complex area situated in the middle of cranial base, with pituitary gland central position and anatomically close to crossroads vital structures, which makes basis for development numerous endocrinological neurological conditions caused by expansion or secretory activity tumor tissue. In this article, we will summarize literature enclosing histopathological immunohistochemical aspects tumors, together clinical characteristics, being key elements making proper...
Generalized perforating granuloma annulare (GPGA) is a very rare form of annulare, with only 31 reported cases to the best our knowledge. Furthermore, GPGA chronic disease that mimics many diseases, no known exact etiology, resulting in lack specific clinical criteria leading guidelines for diagnosis and therapy. In GPGA, papules are predominant lesions followed by central crusting/scaling or umbilication; pustules, plaques, annular nodules less frequent. We report 66-year-old woman who...
Abstract Pachyonychia congenita (PC) is a rare inherited disorder of keratinization characterized by hypertrophic nail dystrophy, painful palmoplantar blisters, cysts, follicular hyperkeratosis and oral leukokeratosis. These pathological clinical features are resulting from mutations in keratin proteins including KRT6A, KRT6B, KRT6C, KRT16, KRT17. We present 6-year-old girl with hyperkeratosis, circumscribed plantar keratoderma The were consistent the diagnosis PC. patient has been...