Abstract Pustular psoriasis ( PP ) is rare in children. The small number of reported cases makes deciding on treatment and follow‐up challenging. current study was an evaluation approaches courses 18 children diagnosed followed over a 20‐year period. From 1992 to 2011 we treated 1,447 with psoriasis, whom had . Follow‐up 2 19 years. At the time initial manifestation , our patients were 1.5 months 16 years old. Seven previous history vulgaris. Three entered long‐term remission after one...

While most previous surveys on the clinico-epidemiological features of autoimmune bullous diseases (AIBDs) have predominantly focused a single disease entity or just one group, there been only few studies examining incidence various AIBDs. In present study, we set out to determine spectrum AIBDs, estimate common and examine their temporal trends in Central Serbia over period 20 years.We retrospectively recruited 1,161 new AIBD cases diagnosed during from January 1991 December 2010. The...

<i>Background:</i> Vitamin A and D analogues play an important role in epidermal homeostasis are used the treatment of various skin diseases. The failure retinoid vitamin treatments is sometimes difficult to explain. <i>Methods:</i> We analyzed effect all-<i>trans</i> retinoic acid (all-<i>trans</i> RA), 13-<i>cis</i> (13-<i>cis</i> ergocalciferol cholecalciferol keratinocyte cultures established from adult donors, on...

Incontinentia pigmenti (IP) is a rare skin disease combined with anomalies of the teeth, eyes, and central nervous system (CNS). Mutations IKBKG gene are responsible for IP. Among most frequent CNS abnormalities found in IP using magnetic resonance imaging (MRI) corpus callosum (CC) abnormalities. The aim study was to determine presence CC abnormalities, their relationship mutations, possible mutations other genes. A group seven patients examined. Analyses X-chromosome inactivation pattern...

Background: Psoriasis is a common chronic inflammatory skin disease with strong genetic basis.Cytokines such as tumor necrosis factor alpha (TNF-α), interleukins (ILs) are IL-12 and IL-23, interferon gamma (IFN-γ) released from various resident cells, have been implicated in the initiation/maintenance of inflammation.Certain alleles aforementioned cytokines may be associated susceptibility/severity. Objective: To investigate association three functional gene polymorphisms, namely TNF -308...

Hailey-Hailey disease is a rare chronic autosomal-dominant blistering characterized by erosions, fissures, and vegetations occurring in intertriginous regions.To date, there no specific treatment are therapeutic guidelines, which makes management of the challenging.We present case 43-year-old man unsuccessfully treated for with topical systemic corticosteroids, antibiotics, surgical debridement.At presentation he had vegetations, infection axillae groin.We introduced oral methotrexate, 10 mg...

Summary We examined rs2201841 within IL ‐23R gene in Serbian patients with psoriasis and healthy controls. G allele frequency was significantly increased the group of psoriatic arthritis compared controls (0.481 vs 0.308). Carriage increases risk to develop ( P = 0.009, OR 3.311, 95% CI 1.29–8.70).

Die meisten früheren Arbeiten zu den klinisch-epidemiologischen Merkmalen von bullösen Autoimmunerkrankungen (AIBD) konzentrierten sich vor allem auf eine einzige Krankheitsentität oder nur Krankheitsgruppe; in wenigen Studien wurde die Inzidenz verschiedener AIBD untersucht. Bei der vorliegenden Studie war es unser Ziel, das gesamte Spektrum betrachten, häufigsten ermitteln und zeitlichen Trends ihres Auftretens Zentralserbien über einen Zeitraum 20 Jahren untersuchen.Wir rekrutierten...

Direct immunofluorescence of peri-lesional skin is the gold standard in diagnosis pemphigus. A specific pattern may also be demonstrated outer root sheath anagen and telogen hair. We an intercellular reticular deposition immunoglobulin G plucked hair all pemphigus vulgaris patients with active disease for first time foliaceus. Moreover, we that samples kept at −20°C least 2 weeks before immunofluorescent staining analysis.

Mastocytosis is a heterogeneous group of rare disorders characterized by the accumulation clonal mast cells in organs such as skin and bone marrow. The diagnosis cutaneous mastocytosis (CM) based on clinical findings, positive Darier's sign, histopathology, if necessary.Medical records 86 children with CM diagnosed during 35-year long period were reviewed. Most patients (93%) developed first year life (median age 3 months). Clinical features at presentation follow-up analyzed. Baseline serum...

Abstract Seborrheic keratosis is the most common slow‐growing, benign epithelial tumour, usually appearing on sun‐exposed areas. Treatment modalities for seborrheic may be uncomfortable and/or time‐consuming. We present a case series of 12 patients with solitary localized face treated 0.005% calcipotriol ointment. The treatment lasted 3–8 months and resulted in complete regression lesions. Remission (follow‐up period) from 6 to 10 years. conclude that topical useful option keratosis.

We report three adolescents with pemphigus vulgaris whose disease started at the age of 13, 15 and 14 years, respectively. The course treatment approaches were reviewed. Pemphigus during childhood adolescence is a very rare in this part Europe. Among 410 patients that we treated 20-year period, only (0.73%) under 18 years. According to our experience, before years comparable adults.

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Abstract In Europe, only 1% of all patients with lichen planus are children. We report a case in 5-year-old boy blisters developing on papules. There was no history Hepatitis B virus vaccination the past 12 months. Routine laboratory analyses showed abnormalities. surface antigen and anti-Hepatitis C antibodies were negative. Our patient had disseminated coalesced papules trunk extremities vesicles bullae hands feet. Histopathology confirmed diagnosis bullous planus. Negative direct...

Abstract Basal cell carcinoma (BCC) is the most common type of skin cancer in Caucasian population. However, BCC genitalia extremely rare. To best our knowledge, only 30 patients with have been reported literature so far. usually occurs individuals over age 50, on sun-exposed areas body, and it more prevalent females. Superficial BCCs account for approximately 10% BCC, are commonly found trunk or limbs. This a report 55-year-old male patient penile review this condition. The presented...

Introduction. Spitzoid lesions represent a spectrum of melanocytic comprising benign Spitz nevi, intermediate known as atypical tumors, and melanoma. They tend to be more common in children young adults, but all age groups can affected. Due complexity their clinical, dermoscopic histological differentiation, they are extremely difficult manage, especially pediatric population. Outlines cases. In this report, we present series six cases with spitzoid different outcomes. Conclusion. With the...