A5090835364- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Metal complexes synthesis and properties
- Boron Compounds in Chemistry
- Radiopharmaceutical Chemistry and Applications
- HIV/AIDS drug development and treatment
- Ferrocene Chemistry and Applications
- Organometallic Compounds Synthesis and Characterization
- Organometallic Complex Synthesis and Catalysis
- Synthesis and biological activity
- Phytochemistry and biological activity of medicinal plants
- Nitric Oxide and Endothelin Effects
- Diabetes and associated disorders
- Bone health and treatments
- PI3K/AKT/mTOR signaling in cancer
- Quinazolinone synthesis and applications
- Nanoplatforms for cancer theranostics
- Protein Degradation and Inhibitors
- interferon and immune responses
- Melanoma and MAPK Pathways
- Cancer, Hypoxia, and Metabolism
- Bioactive Compounds and Antitumor Agents
- Nanoparticle-Based Drug Delivery
- Crystal structures of chemical compounds
- Biological and pharmacological studies of plants
University of Belgrade
2016-2025
Institute for Biological Research “Siniša Stanković”
2014-2024
Institute for Biological Sciences
2001-2017
Institute of Molecular Genetics and Genetic Engineering
2009-2012
University of Catania
2009-2012
Northwell Health
2009-2012
East Carolina University
2009-2012
Wilmington University
2009
Institute of Biophysics
2008
Institute for Biodiversity
2002-2004
The purpose of this paper is to summarize mode action cisplatin on the tumor cells, a brief outlook metallocene compounds as antitumor drugs well future tendencies for use latter in anticancer chemotherapy. Molecular mechanisms interaction with DNA, DNA repair mechanisms, and cellular proteins are discussed. background sensitivity resistance cisplatin, its influence efficacy immune response was evaluated. Furthermore, herein summarized some metallocenes (titanocene, vanadocene, molybdocene,...
Three triphenyltin( iv ) compounds with carboxylato N -functionalized 2-quinolones are reported. The showed remarkable anticancer activity in lower micromolar concentrations. most active compound exhibited a better vivo profile than cisplatin.
Abstract The strong therapeutic potential of an organotin(IV) compound loaded in nanostructured silica (SBA‐15pSn) is demonstrated: B16 melanoma tumor growth syngeneic C57BL/6 mice almost completely abolished. In contrast to apoptosis as the basic mechanism anticancer action numerous chemotherapeutics, important advantage this SBA‐15pSn mesoporous material induction cell differentiation, effect unknown for metal‐based drugs and nanomaterials alone. This non‐aggressive mode drug highly...
FETPY, an organo-diiron(I) complex, showed strong cytotoxicity across a panel of human and mouse cancer cell lines, combined with outstanding selectivity compared to nonmalignant cells. Enhanced iron uptake in aggressive, low-differentiated caused membrane lipid peroxidation, which resulted ferroptosis ovarian FETPY induced significant morphological changes murine B16–F1 B16–F10 melanoma cells, leading senescence and/or trans-differentiation into Schwann-like thus significantly reducing...
Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine that plays pivotal role in several immunoinflammatory and autoimmune diseases. In this study we examined the of MIF development diabetes induced susceptible strains mice by multiple low doses streptozotocin. We found protein was significantly elevated islet cells during diabetes, targeting activity with either neutralizing antibody or pharmacological inhibitor (S,R)-3-(4-hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic...
Abstract Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine of the innate immune system that plays major role in induction immunoinflammatory responses. To examine endogenous MIF pathogenesis type 1 diabetes (TID) we evaluated effects administration neutralizing anti‐MIF antibodies to NOD mice with accelerated forms induced by injection cyclophosphamide or transfer diabetogenic spleen cells. Both were markedly reduced antibody. Furthermore, MIF‐deficient (MIF −/− )...
Abstract Preclinical studies have shown that nitric oxide (NO)–donating nonsteroidal anti-inflammatory drugs possess anticancer activities. Here, we report in vitro and vivo showing the antitumor effect of NO-donating isoxazole derivative (S,R)-3-phenyl-4,5-dihydro-5-isoxazole acetic acid (GIT-27NO). GIT-27NO, but not NO-deprived parental compound VGX-1027, significantly affected viability both rodent (L929, B16, C6) human (U251, BT20, HeLa, LS174) tumor cell lines. GIT-27NO triggered either...
Anticancer activities of various extracts the medicinal mushroom, Ganoderma lucidum, have been widely demonstrated and are mainly associated with presence different bioactive polysaccharides triterpenoids. We evaluated compared in vitro vivo antitumor effects two preparations from lucidum: a methanol extract containing total terpenoids (GLme) purified acidic (GLpme). Both inhibited tumor growth B16 mouse melanoma cells inoculated subcutaneously into syngeneic C57BL/6 mice reduced viability...
In vitro studies have shown that hydrogen peroxide (H2O2) produced by high-concentration ascorbate and cell culture medium iron efficiently kills cancer cells. This provided the rationale for clinical trials of high-dose intravenous ascorbate-based treatment cancer. A drawback in all was their failure to take into account vivo concentration supplement media which are characterized low content. Here we showed, using two prostate lines (LNCaP PC-3) primary astrocytes, anticancer/cytotoxic...
Wound healing of acute full-thickness injuries and chronic non-healing ulcers leads to delayed wound closure, prolonged recovery period hypertrophic scarring, generating a demand for an autologous cell therapy relevant pre-clinical research models healing. In this study, immunocompetent model was employed using syngeneic murine line mesenchymal stem cells cultured from the mouse whisker hair follicle outer root sheath (named moMSCORS). moMSCORS were isolated air-liquid interface method,...
The (pentamethylcyclopentadienyl)chloridoiridium(III) complex bearing a κP,κS-bonded Ph2PCH2CH2SPh ligand ([Ir(η5-C5Me5)Cl(Ph2P(CH2)2SPh-κP,κS)]PF6, (1)] was synthesized and characterized. Multinuclear (1H, 13C 31P) NMR spectroscopy employed for the determination of structure. Moreover, SC-XRD confirmed proposed structure belongs to “piano stool” type. Hirshfeld surface analysis outlined most important intermolecular interactions in crystallographic optimized at...