A5082185876- Macrophage Migration Inhibitory Factor
- Immune Cell Function and Interaction
- Diabetes and associated disorders
- Nuclear Receptors and Signaling
- Apelin-related biomedical research
- Atherosclerosis and Cardiovascular Diseases
- T-cell and B-cell Immunology
- Natural Antidiabetic Agents Studies
- Immunotherapy and Immune Responses
- IL-33, ST2, and ILC Pathways
- Immune Response and Inflammation
- Pancreatic function and diabetes
- Phytochemicals and Antioxidant Activities
- Eosinophilic Esophagitis
- Ruminant Nutrition and Digestive Physiology
- Diet, Metabolism, and Disease
- Heme Oxygenase-1 and Carbon Monoxide
- Neonatal Health and Biochemistry
- Cholesterol and Lipid Metabolism
- Diabetes Management and Research
- Fungal Biology and Applications
- Medication Adherence and Compliance
- Redox biology and oxidative stress
- Cannabis and Cannabinoid Research
- Diabetes Treatment and Management
University of Belgrade
2015-2024
Shaheed Rajaei Cardiovascular Medical and Research Center
2022
Association Française pour le Dépistage et la Prévention des Handicaps de l’Enfant
2022
Institute for Biological Research “Siniša Stanković”
2008-2020
University of Nis
2020
Avalon Pharma (United States)
2016-2018
Institute for Biological Sciences
2017
University of Montenegro
2016
Klinikum St. Georg
2015
Praxis
2015
Abstract Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine of the innate immune system that plays major role in induction immunoinflammatory responses. To examine endogenous MIF pathogenesis type 1 diabetes (TID) we evaluated effects administration neutralizing anti‐MIF antibodies to NOD mice with accelerated forms induced by injection cyclophosphamide or transfer diabetogenic spleen cells. Both were markedly reduced antibody. Furthermore, MIF‐deficient (MIF −/− )...
Interleukin (IL)-17 is a pro-inflammatory cytokine produced by recently described T helper type 17 (Th17) cells, which have critical role in immunity to extracellular bacteria and the pathogenesis of several autoimmune disorders. IL-6 transforming growth factor (TGF)-beta are crucial for generation Th17 cells mice, while production IL-17 supported various cytokines, including IL-23, IL-1beta, IL-21, IL-15 tumour necrosis (TNF)-alpha. In this study, influence multifunctional cytokine,...
Anticancer activities of various extracts the medicinal mushroom, Ganoderma lucidum, have been widely demonstrated and are mainly associated with presence different bioactive polysaccharides triterpenoids. We evaluated compared in vitro vivo antitumor effects two preparations from lucidum: a methanol extract containing total terpenoids (GLme) purified acidic (GLpme). Both inhibited tumor growth B16 mouse melanoma cells inoculated subcutaneously into syngeneic C57BL/6 mice reduced viability...
Type 1 diabetes (T1D), an autoimmune inflammatory disorder, develops as a consequence of pancreatic β-cell destruction and results in hyperglycaemia. Since current T1D therapy mainly involves insulin replacement, the aim present study was to evaluate therapeutic potential Origanum vulgare L. ssp. hirtum (Greek oregano) leaf extract rich biophenols for treatment T1D. The phytochemical profile methanolic oregano (MOE) aqueous (AOE) determined by liquid chromatography/electrospray ion-trap...
Beta cell apoptosis is a hallmark of diabetes. Since we have previously shown that galectin-3 deficient (LGALS3(-/-) ) mice are relatively resistant to diabetes induction, the aim this study was examine whether beta depends on presence and delineate underlying mechanism. Deficiency galectin-3, either hereditary or induced through application chemical inhibitors, β-lactose TD139, supported survival function islet cells compromised by TNF-α + IFN-γ IL-1β stimulus. Similarly, inhibition TD139...
Wound healing of acute full-thickness injuries and chronic non-healing ulcers leads to delayed wound closure, prolonged recovery period hypertrophic scarring, generating a demand for an autologous cell therapy relevant pre-clinical research models healing. In this study, immunocompetent model was employed using syngeneic murine line mesenchymal stem cells cultured from the mouse whisker hair follicle outer root sheath (named moMSCORS). moMSCORS were isolated air-liquid interface method,...
As a result of chronic exposure to high levels free fatty acids, glucose and inflammatory mediators β‐cell apoptosis occurs at the end stage obesity‐associated type 2 diabetes (T2D). One potentially deleterious molecule for function associated with T2D obesity in humans is macrophage migration inhibitory factor (MIF). Therefore, aim this study was explore MIF expression vivo during development insulin resistance high‐fat diet (HFD)‐fed C57BL/6 mice whether inhibition could affect dysfunction...
Chokeberry (Aronia melanocarpa) is known for its anti-oxidant, anti-inflammatory and anti-diabetic properties. Since the effects of chokeberry extract on immune response have been only sporadically assessed, our aim was to investigate fruit water in vivo vitro. When administered orally healthy mice, exerted immunomodulatory gut evidenced by altered proportion macrophages, dendritic cells T cells. Importantly, oral consumption resulted blood glucose level increase C57BL/6 mice with...
Abstract Astrocytes play important roles in the complex and as yet not very well understood net of interactions among resident infiltrating cells during central nervous system (CNS) inflammation. In such an intricate network, cytokines represent essential means for intercellular communication, astrocytes are able to affect their generation and/or release. Among various produced by cells, interferon (IFN)‐γ interleukin (IL)‐17 focus this research, because they pivotal helper T‐cell type 1...
Summary During pathogenesis of diabetes, pancreatic islets are exposed to high levels cytokines and other inflammatory mediators that induce deterioration insulin-producing beta cells. Macrophage migration inhibitory factor (MIF) plays a key role in the onset development several immunoinflammatory diseases also controls apoptotic cell death. Because occurrence apoptosis pathogenetic death during type 1 diabetes MIF is expressed cells, we explored influence deficiency on cytokine-induced...
Alzheimer's disease (AD) is characterized by accumulation of amyloid-β plaques that further promotes microglia-mediated neuroinflammatory responses and inflammation in the brain. Emerging data are revealing relation between gut-associated lymphoid tissue (GALT) cells CNS, as effector primed gut might home to This study aimed determine cell composition GALT 5xFAD mice, an established model for AD. Immune isolated from Peyer's patches (PP) mesenteric lymph nodes (MLN) were stained with surface...
Type 1 diabetes (T1D) is an autoimmune disease in which a strong inflammatory response causes the death of insulin-producing pancreatic β-cells, while inefficient regulatory mechanisms allow that to become chronic. Ethyl pyruvate (EP), stable derivate and certified inhibitor alarmin - high mobility group box (HMGB1), exerts anti-oxidant anti-inflammatory properties animal models rheumatoid arthritis encephalomyelitis. To test its therapeutic potential T1D, EP was administered...
Recent data indicate the link between number and function of T regulatory cells (Treg) in gut immune tissue initiation development autoimmunity associated with type 1 diabetes (T1D). Since 3 innate lymphoid (ILC3) small intestine are essential for maintaining FoxP3+ Treg there no about possible role ILC3 T1D pathogenesis, aim this study was to explore ILC3-Treg during T1D. Mature diabetic NOD mice had lower frequencies IL-2-producing lamina propria (SILP) compared prediabetic mice....
The health-promoting effects of various constituents the olive tree ( Olea europaea ) are mainly associated with hypoglycaemic and insulin-sensitising activities have been widely demonstrated in metabolic syndrome type 2 diabetes. However, their biological activity autoimmune 1 diabetes (T1D) is poorly characterised. Therefore, influence O. -derived components present dry leaf extract (DOLE) was examined two established preclinical models human T1D, which differ some aspects diabetogenesis:...
Abstract Macrophage migration inhibitory factor (MIF) is a multifunctional protein that involved in the development of gut-related inflammation. To investigate role MIF function intestinal barrier, we have explored permeability and gut-associated immune response MIF-deficient (MIF-KO) mice. The absence provoked impairment tight adherens epithelial junctions colon through disturbance E-cadherin, zonula occludens-1, occludin claudin-2 expression, which lead to increase barrier permeability. In...