A5044625301- Mesenchymal stem cell research
- melanin and skin pigmentation
- Hair Growth and Disorders
- Wound Healing and Treatments
- Silk-based biomaterials and applications
- Cancer-related molecular mechanisms research
- Periodontal Regeneration and Treatments
- Clusterin in disease pathology
- Nerve injury and regeneration
- Pancreatitis Pathology and Treatment
- Skin Protection and Aging
- Ferroptosis and cancer prognosis
- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- MicroRNA in disease regulation
- Insect Pest Control Strategies
- RNA regulation and disease
- Caveolin-1 and cellular processes
- Biomarkers in Disease Mechanisms
- Pancreatic and Hepatic Oncology Research
- Osteoarthritis Treatment and Mechanisms
- Oral microbiology and periodontitis research
- Dermatologic Treatments and Research
University Hospital Leipzig
2004-2024
Leipzig University
2005-2024
Saxon Academy of Sciences and Humanities in Leipzig
2017-2021
TU Dresden
2014
Leibniz Institute of Polymer Research
2014
Fraunhofer Institute for Cell Therapy and Immunology
2010
Klinik und Poliklinik für Psychosomatische Medizin und Psychotherapie
2004-2006
University of Belgrade
2003-2004
This research aimed to investigate the anti-tumor effects and underlying genetic mechanisms of herbal medicine Triphala (TRP) in oral squamous cell carcinoma (OSCC). The target genes (OSCC) were identified, subsequent functional enrichment analysis was conducted determine enriched signaling pathways. Based on these genes, a protein-protein interaction network constructed identify top 10 with highest degree. Genes deregulated OSCC tumor samples identified be hub among genes. In vitro...
Wound healing of acute full-thickness injuries and chronic non-healing ulcers leads to delayed wound closure, prolonged recovery period hypertrophic scarring, generating a demand for an autologous cell therapy relevant pre-clinical research models healing. In this study, immunocompetent model was employed using syngeneic murine line mesenchymal stem cells cultured from the mouse whisker hair follicle outer root sheath (named moMSCORS). moMSCORS were isolated air-liquid interface method,...
To identify the genetic linkage mechanisms underlying Parkinson's disease (PD) and periodontitis, explore role of immunology in crosstalk between both these diseases.The gene expression omnibus (GEO) datasets associated with whole blood tissue PD patients gingival periodontitis were obtained. Then, differential analysis was performed to differentially expressed genes (DEGs) deregulated diseases, which defined as genes. Inflammatory response-related (IRRGs) downloaded from MSigDB database...
Objective. To identify the shared genetic and epigenetic mechanisms between osteogenic differentiation of dental pulp stem cells (DPSC) bone marrow (BMSC). Materials Methods. The profiling datasets miRNA expression in mesenchymal from (BMSC) were searched Gene Expression Omnibus (GEO) database. differential analysis was performed to differentially expressed miRNAs (DEmiRNAs) dysregulated DPSC BMSC osteodifferentiation. target genes DEmiRNAs that osteodifferentiation identified, followed by...
Abstract Background The R122H mutation of the cationic trypsinogen was found in patients with hereditary pancreatitis. A transgenic animal carrying this could be useful as a genetic model system Methods Mice for human were generated using -205 fragment rat elastase promoter. presence transgene assayed DNA, pancreatic mRNA and zymogen granule lysates. Serum levels amylase, lipase cytokines (MCP-1, IL-6) monitored histological appearance tissue investigated. Pancreatitis induced by 7 hourly...
Background: Regenerative therapies based on autologous mesenchymal stem cells (MSC) as well in general are still facing an unmet need for non-invasive sampling, availability, and scalability. The only known adult source of MSCs permanently available with no pain, discomfort, or infection risk is the outer root sheath hair follicle (ORS). Methods: This study presents a non-invasively-based method isolating expanding from ORS (MSCORS) by means cell migration expansion air–liquid culture....
Hair follicle outer root sheath (ORS) is a putative source of stem cells with therapeutic capacity. ORS contains several multipotent cell populations, primarily in the distal compartment bulge region. However, routinely obtained using invasive isolation methods, which require human scalp tissue ex vivo. Non-invasive sampling has been standardized by means plucking procedure, enabling to reproducibly obtain mid-ORS part. The shows potential for giving rise multiple populations vitro. To...
This study aimed to identify the programmed death ligand-1 (PDL1, also termed as CD274) and its positively correlated immune checkpoint genes (ICGs) determine subtypes of CD274-centered ICG combinations in oral squamous cell carcinoma (OSCC).Firstly, 95 ICGs obtained via literature reviews were identified Cancer Genome Atlas (TCGA) database relation OSCC, such 88 expression profiles extracted. with CD274 utilized for subsequent analysis. The relationship between immunotherapy biomarkers...
Background. Head and neck squamous cell carcinoma (HNSCC) is a significant health problem related to poor long-term outcomes, indicating more research be done deeply understand the underlying pathways. Objective. This current study aimed in assessment of viral- (especially human papilloma virus [HPV]) carcinogen-driven head microenvironment based on single-cell sequencing analysis. Methods. Data were downloaded from GEO database (GSE139324), including 131224 cells 18 HP- HNSCC patients 8...
Background: The mechanisms through which immunosuppressed patients bear increased risk and worse survival in oral squamous cell carcinoma (OSCC) are unclear. Here, we used deep learning to investigate the genetic underlying immunosuppression of OSCC patients, especially from aspect various survival-related subtypes. Materials methods: samples data were obtained Cancer Genome Atlas (TCGA), International Consortium (ICGC), OSCC-related datasets with National Center for Biotechnology...
Mesenchymal stem cells (MSCs) are known for their immunosuppressive properties. Based on the demonstrated anti-inflammatory effect of mouse MSCs from hair follicles (moMSCORS) in a murine wound closure model, this study evaluates potential preventing type 1 diabetes (T1D) C57BL/6 mice. T1D was induced mice by repeated low doses streptozotocin. moMSCORS were injected intravenously weekly basis. reduced incidence, insulitis stage, and preserved insulin production treated animals. primarily...
This study investigated the nature of shared transcriptomic alterations in PBMs from periodontitis and atherosclerosis to unravel molecular mechanisms underpinning their association. Gene expression data patients with those were each downloaded GEO database. Differentially expressed genes (DEGs) identified through differential gene analysis. The disease-related known related DisGeNET A Venn diagram was constructed identify crosstalk four categories: DEGs periodontitis, periodontitis-related...
Periodontitis is a global, multifaceted, chronic inflammatory disease caused by bacterial microorganisms and an exaggerated host immune response that not only leads to the destruction of periodontal apparatus but may also aggravate or promote development other systemic diseases. The periodontium composed four different tissues (alveolar bone, cementum, gingiva, ligament) various non-surgical surgical therapies have been used restore its normal function. However, due etiology heterogeneous...
Abstract The easily accessible niche represented by skin and its appendages may serve as a promising source to complement modern regenerative medicine for horses. In humans in animal models human medicine, the hair follicle stem cell niches are well characterized. Since literature this field of equine research is scarce, we sought analyze cells dermal morphologically subset markers useful characterization via immunolabeling. We cultured forelock explants obtain cultures with migrating from...
Melanocytes differentiated from the stem cells of human hair follicle outer root sheath (ORS) have potential for developing non-invasive treatments skin disorders out a minimal sample: root. With robust procedure melanocyte cultivation ORS at hand, this study focused on identification suitable biocompatible, biodegradable carrier as next step toward their clinical implementation. Polycaprolactone (PCL) is known biocompatible material used number medical devices. In study, we populated...
Overactivation of renin-angiotensin system (RAS) is one the main pathophysiological features in evolution chronic heart failure (CHF). The (pro)renin receptor ((P)RR) represents an important player a tissue (tissue RAS), which mediates injury through fibrosis and hypertrophy affected organs CHF patients. In our study we used plasma samples from 556 elderly subjects with 198 healthy participants order to evaluate prognostic diagnostic potential s(P)RR setting CHF. patients showed...
The rich inversion polymorphism of chromosomes Drosophila subobscura varies in association with environmental changes at spatial and temporal level. Due to random factors this might become less regular be the reason that there is little evidence altitudinal seasonal, microgeographic habitat-related variability. variability gene arrangement frequencies over daytime period was investigated populations D. from two ecologically different habitats. According parameters fit into existing patterns...