A5029381877- Facial Trauma and Fracture Management
- Cleft Lip and Palate Research
- Reconstructive Surgery and Microvascular Techniques
- Head and Neck Cancer Studies
- Craniofacial Disorders and Treatments
- Dental Implant Techniques and Outcomes
- Ophthalmology and Eye Disorders
- Dental Radiography and Imaging
- Tracheal and airway disorders
- Facial Nerve Paralysis Treatment and Research
- Cancer Cells and Metastasis
- Bone Tissue Engineering Materials
- Mesenchymal stem cell research
- Periodontal Regeneration and Treatments
- Traumatic Ocular and Foreign Body Injuries
- Spinal Fractures and Fixation Techniques
- Temporomandibular Joint Disorders
- Pituitary Gland Disorders and Treatments
- Meningioma and schwannoma management
- Reconstructive Facial Surgery Techniques
- Facial Rejuvenation and Surgery Techniques
- Advanced Radiotherapy Techniques
- Cancer Immunotherapy and Biomarkers
- Angiogenesis and VEGF in Cancer
- Oral and Maxillofacial Pathology
University Children's Hospital Tübingen
2025
University Hospital Leipzig
2021-2024
Leipzig University
2021-2023
Medizinische Hochschule Hannover
2011-2021
Klinik und Poliklinik für Mund-, Kiefer- und Gesichtschirurgie
2015-2020
Klinikum Bremerhaven-Reinkenheide
2019
University Medical Center Freiburg
2015
The role of CD44 in progression head and neck squamous cell carcinoma (HNSCC) has been controversial. goal this study was to the effects CD44(+) tumor cells on initial stages angiogenesis evaluate as a potential marker angiogenesis. gene expression studied using Cancer Genome Atlas (TCGA) Head Neck data base. Expression levels microvascular density (MVD) markers were assessed by immunohistochemistry performed with tissue microarrays cohort 49 HNSCC patients, 11 patients dysplasia 12 control...
This research aimed to investigate the anti-tumor effects and underlying genetic mechanisms of herbal medicine Triphala (TRP) in oral squamous cell carcinoma (OSCC). The target genes (OSCC) were identified, subsequent functional enrichment analysis was conducted determine enriched signaling pathways. Based on these genes, a protein-protein interaction network constructed identify top 10 with highest degree. Genes deregulated OSCC tumor samples identified be hub among genes. In vitro...
Recent evidence suggests a subset of cells within tumor with "stem-like" characteristics. These are able to transplant tumors in immunodeficient hosts. Distinct from non-malignant stem cells, cancer (CSC) show low proliferative rates, high self-renewing capacity, propensity differentiate into actively proliferating and resistance chemotherapy or radiation. They often characterized by elevated expression cell surface markers, particular CD133, sets differentially expressed cell-associated...
Abstract Objectives The aim of the current study was to evaluate potential differences in accuracy mandibular reconstruction and long-term stability, with respect different reconstructive procedures. Methods In total, 42 patients who had undergone primary segmental resection immediate alloplastic reconstruction, either manually pre-bent or patient-specific plates (PSMRP), were included this study. Mandibular dimensions, terms six clinically relevant distances (capitulum [most lateral...
Mesenchymal stem cells (MSCs) represent the most commonly utilized type of cell in clinical applications. However, variability quality and quantity between different tissue sources donors presents a significant challenge to their use. Induced pluripotent (iPSCs) are promising abundant alternative source MSCs, offering potential solution limitations adult MSCs. Nevertheless, standardized protocol for differentiation iPSCs into iPSC-derived mesenchymal (iMSCs) has yet be established, as...
Every endosseous dental implant is dependent on an adequate amount and quality of peri-implant hard soft tissues their fully functional interaction. The could fail in cases insufficient bone or due to a violation the shoulder interface with arising secondary loss.To overcome this biological weak-spot, we designed new that allows for multi vector anchorage around individual underlying bone, which has be scanned by computed tomography (CT) Cone beam CT (CBCT) technique allow planning implant....
Reconstruction of orbital wall fractures is demanding and has improved dramatically with the implementation new technologies. True-to-original accuracy reconstruction been deemed essential for good clinical outcome, reasons unfavorable outcome have researched extensively. However, no detailed analysis on influence plate position surface contour yet published.Data from a previous study were used an ad-hoc to identify predictors defined as diplopia or differences in globe height and/or...
<b><i>Background:</i></b> Posttherapeutic mucositis is a common secondary effect of oral cancer treatment. Mucositis affects the mucosa, which leads to specific physical impairments in function and negative impact on quality life. <b><i>Objective:</i></b> To evaluate associated with their posttherapeutic <b><i>Methods:</i></b> A retrospective analysis was conducted 1,652 patients treated for during multicenter...
In orthopaedic medicine, connective tissues are often affected by traumatic or degenerative injuries, and surgical intervention is required. Rotator cuff tears a common cause of shoulder pain disability among adults. The development graft materials for bridging the gap between tendon bone after chronic rotator essentially limiting factor clinical success tissue engineering construct fast complete vascularization construct. Otherwise, immigrating cells not able to survive longer period time,...
To identify the genetic linkage mechanisms underlying Parkinson's disease (PD) and periodontitis, explore role of immunology in crosstalk between both these diseases.The gene expression omnibus (GEO) datasets associated with whole blood tissue PD patients gingival periodontitis were obtained. Then, differential analysis was performed to differentially expressed genes (DEGs) deregulated diseases, which defined as genes. Inflammatory response-related (IRRGs) downloaded from MSigDB database...
Three-dimensional facial scans have recently begun to play an increasingly important role in the peri-therapeutic management of oral and maxillofacial head neck surgery cases. Face scan images can be generated by optical scanners utilizing line-laser, stereophotography, or structured light modalities, as well from volumetric data: for example, cone beam computed tomography (CBCT). This study aimed evaluate whether two low-cost procedures creation three-dimensional face were capable producing...
Background/Aim: We evaluated survival rates in surgically-treated oral and oropharyngeal squamous cell carcinoma patients at our clinic, determined whether differed by tumour locations. Patients Methods: In a retrospective study, lesions 1,486 were categorized into 6 groups according to location. Patients9 age, sex, tumour-node-metastasis classification, resection status, 5-year disease-specific statistically analysed between groups. Results: A significantly inferior lower for tumours...
Congenital mandibular hypoplasia (CMH) remains challenging because of the underlying combined hard and soft tissue deficiency. Treatment options include craniofacial distraction, orthognathic surgery, autologous grafts, although latter produces inadequate results after distraction grafting. Unsatisfactory long-term stability may cause relapse, necessitating reoperation.We investigated feasibility using alloplastic total joint replacement (TJR) in growing young adult CMH patients. The primary...