A5066277818- Magnesium Alloys: Properties and Applications
- Bone Tissue Engineering Materials
- Aluminum Alloys Composites Properties
- Orthopaedic implants and arthroplasty
- Tendon Structure and Treatment
- Knee injuries and reconstruction techniques
- Shoulder Injury and Treatment
- Hydrogen Storage and Materials
- Sports injuries and prevention
- Corrosion Behavior and Inhibition
- Orthopedic Surgery and Rehabilitation
- Osteoarthritis Treatment and Mechanisms
- Molecular Biology Techniques and Applications
- Layered Double Hydroxides Synthesis and Applications
- Polymer Surface Interaction Studies
- Lower Extremity Biomechanics and Pathologies
- Nerve Injury and Rehabilitation
- Orthopedic Infections and Treatments
- Total Knee Arthroplasty Outcomes
- Nanoparticle-Based Drug Delivery
- Nail Diseases and Treatments
- Bone fractures and treatments
- Bone and Joint Diseases
- Oral microbiology and periodontitis research
- Legionella and Acanthamoeba research
Medizinische Hochschule Hannover
2012-2024
Abstract Current tissue engineering strategies focus on the replacement of pathologically altered tissues by transplantation cells in combination with supportive biocompatible scaffolds. Scaffolds for musculoskeletal research require an appropriate mechanical stability. In recent studies, considerable attention has thus been given to magnesium alloys as biodegradable implants. The aim this study was characterize biocompatibility scaffolds inflammatory host response. Open porous made alloy...
In this study, histomorphometrical parameters of the peri-implant bone remodeling around degrading open-porous scaffolds made magnesium alloy AZ91D were investigated and compared with an autologous transplant in contralateral side a rabbit model after 3 6 months. Osteoblast activity was displayed by collagen I (alpha 2) mRNA situ hybridization. Major scaffold degradation completed within months implantation showing no osteolysis scaffolds, both Enhanced formation unmineralized extracellular...
Biological factors such as TGF–β3 are possible supporters of the healing process in chronic rotator cuff tears. In present study, electrospun chitosan coated polycaprolacton (CS–g–PCL) fibre scaffolds were loaded with and their effect on tendon was compared biomechanically histologically to unloaded a defect rat model. The biomechanical analysis revealed that tendon–bone constructs had significantly lower values for maximum force native tendons. Tendon-bone TGF–β3-loaded showed only slightly...
Abstract Ligament-to-bone and tendon-to-bone interfaces (entheses, osteotendinous junctions [OTJs]) serve to dissipate stress between soft tissue bone. Surgical reconstruction of these is an issue considerable importance as they are prone injury the integration bone tendon/ligament in general not satisfactory. We report here stem cell-dependent spontaneous formation fibrocartilaginous fibrous entheses heterotopic locations mouse if progenitors possess a tenogenic osteo-/chondrogenic...
In orthopaedic medicine, connective tissues are often affected by traumatic or degenerative injuries, and surgical intervention is required. Rotator cuff tears a common cause of shoulder pain disability among adults. The development graft materials for bridging the gap between tendon bone after chronic rotator essentially limiting factor clinical success tissue engineering construct fast complete vascularization construct. Otherwise, immigrating cells not able to survive longer period time,...
Bone fractures often require internal fixation using plates or screws. Normally, these devices are made of permanent metals like titanium providing necessary strength and biocompatibility. However, they can also cause long-term complications may removal. An interesting alternative biocompatible degradable devices, which provide sufficient initial then degrade gradually. Among other materials, biodegradable magnesium alloys have been developed for craniofacial orthopaedic applications....
True tendon regeneration in human patients remains a vision of musculoskeletal therapies. In comparison to other mesenchymal lineages the biology tenogenic differentiation is barely understood. Specifically, easy and efficient protocols are lacking that might enable cell tissue based on adult (stem) sources. murine progenitor line C3H10T½, overexpression growth factor bone morphogenetic protein 2 (BMP2) constitutively active transcription factor, Smad8 L+MH2, mediates vitro formation...
Chronic tendon ruptures are common disorders in orthopedics. The conventional surgical methods used to treat them often require the support of implants. Due non-availability suitable materials, 3D-printed polycaprolactone (PCL) scaffolds were designed from two different starting materials as candidates for tendon-implant applications. For characterization, mechanical testing was performed. To increase their biocompatibility, PCL-scaffolds plasma-treated and coated with fibronectin collagen...
In Brief Study Design. An experimental study using a sheep cervical spine interbody fusion model. Objective. First, to compare anterior discectomy and of an bioabsorbable cage consisting magnesium alloy polymer (poly-ε-caprolactone, PCL) with autologous tricortical iliac crest bone graft. Second, determine the degradation kinetics cage, assess 2 devices for biomechanical stability, their histological characteristics. Summary Background Data. Bioabsorbable cages are not routinely used in...
Abstract The total hip arthroplasty is one of the most common artificial joint replacement procedures. Several different surface coatings have been shown to improve implant fixation by facilitating bone ingrowth and consequently enhancing longevity uncemented orthopaedic prostheses. In present study, two layered double hydroxides (LDHs), Mg‐Fe‐ Mg‐Al‐LDH, were investigated as potential magnesium (Mg)‐containing coating materials for applications in comparison Mg hydroxide (Mg(OH) 2 ). vitro...