A5060769586- Phagocytosis and Immune Regulation
- Wound Healing and Treatments
- Systemic Lupus Erythematosus Research
- Erythrocyte Function and Pathophysiology
- Proteoglycans and glycosaminoglycans research
- Immune Cell Function and Interaction
- Cell death mechanisms and regulation
- Immune cells in cancer
- Dermatology and Skin Diseases
- Immunotherapy and Immune Responses
- Fibroblast Growth Factor Research
- T-cell and B-cell Immunology
- RNA Interference and Gene Delivery
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- IL-33, ST2, and ILC Pathways
- Cell Adhesion Molecules Research
- Psoriasis: Treatment and Pathogenesis
- Tissue Engineering and Regenerative Medicine
- Galectins and Cancer Biology
- S100 Proteins and Annexins
- Immune Response and Inflammation
- Mesenchymal stem cell research
- Connective tissue disorders research
- Adipokines, Inflammation, and Metabolic Diseases
- Nerve injury and regeneration
Leipzig University
2015-2025
Klinik und Poliklinik für Neurologie
2024
University Hospital Leipzig
2017-2024
Deutsche Forschungsgemeinschaft
2016
Ludwig-Maximilians-Universität München
2014
Friedrich-Alexander-Universität Erlangen-Nürnberg
2003-2012
University of Edinburgh
2009-2011
Centre for Inflammation Research
2009
Queen's Medical Centre
2009
Medical Research Council
2009
Glycosaminoglycan-based hydrogels scavenge proinflammatory chemokines, reduce the influx of immune cells, and improve healing chronic wounds.
Sustained inflammation associated with dysregulated macrophage activation prevents tissue formation and healing of chronic wounds. Control immune cell functions thus represents a promising approach in the development advanced therapeutic strategies. Here we describe immunomodulatory hyaluronan/collagen (HA-AC/coll)-based hydrogels containing high-sulfated hyaluronan (sHA) as immunoregulatory component for modulation inflammatory activities disturbed wound healing. Solute sHA downregulates...
CTLA-4 is a regulator of co-stimulation and inhibits the activation T cells through interfering with interaction CD80/86 on antigen-presenting CD28 cells. binds to surface cells, such as dendritic monocytes CD80/86. Monocytes can differentiate in osteoclasts, primary bone resorbing Herein, we investigated whether binding affects differentiation into osteoclasts vitro vivo. We show that dose-dependently RANKL- well tumour necrosis factor (TNF)-mediated osteoclastogenesis without presence...
Dynamic alterations of composition and mechanics the extracellular matrix are suggested to modulate cellular behavior including plasticity macrophages (MPhs) during wound healing. In this study, engineered 3D fibrillar matrices based on naturally occurring biopolymers (collagen I, glycosaminoglycans (GAGs)) used mimic stiffening as well modification by sulfated nonsulfated GAGs at different stages Human MPhs found sensitively respond these microenvironmental cues in terms polarization toward...
Macrophages, renowned for clearance of debris and bacteria in the wound, can also uptake signaling inhibitors to promote fibrosis.
Rationale:In obesity the fine-tuned balance of macrophage phenotypes is disturbed towards a dominance pro-inflammatory macrophages resulting in exacerbation and persistence inflammation impaired tissue repair.However, underlying mechanisms are still poorly understood.Methods: Impact on differentiation was studied high fat diet induced obese db/db mice during skin wound repair, respectively.Mechanisms S100A9-mediated effects vitro generated by genomic proteomic approaches.The role S100A9...
During resolution of an inflammatory response, recruited neutrophil granulocytes undergo apoptosis and are removed by tissue phagocytes before induction secondary necrosis without provoking proinflammatory cytokine production release. Promotion physiological clearance mechanisms may represent a viable therapeutic strategy for the treatment or autoimmune diseases in which removal apoptotic cells is impaired. The mechanism underlying enhancement macrophage capacity phagocytosis powerful...
Integration of biomaterials into tissues is often disturbed by unopposed activation macrophages. Immediately after implantation, monocytes are attracted from peripheral blood to the implantation site where they differentiate Inflammatory signals sterile tissue injury around implanted biomaterial mediate differentiation inflammatory M1 macrophages (M1) via autocrine and paracrine mechanisms. Suppression sustained thought be crucial improve implant healing. Here, we explore whether artificial...
Inappropriate clearance of apoptotic remnants is considered to be the primary cause systemic autoimmune diseases, like lupus erythematosus. Here we demonstrate that cells release distinct types subcellular membranous particles (scMP) derived from endoplasmic reticulum (ER) or plasma membrane. Both scMP exhibit desialylated glycotopes resulting surface exposure immature ER-derived glycoproteins surface-borne sialidase activity, respectively. Sialidase activity activated by caspase-dependent...
// Animesh Bhattacharya 1 , Ulf Schmitz 2 Yvonne Raatz Madeleine Schönherr Tina Kottek Marianne Schauer Sandra Franz Anja Saalbach Anderegg Olaf Wolkenhauer Dirk Schadendorf 3 Jan C. Simon Thomas Magin 4 Julio Vera 5 and Manfred Kunz Department of Dermatology, Venereology Allergology, University Leipzig, Germany Systems Biology Bioinformatics, Rostock, Hospital Essen, Institute Translational Centre for Regenerative Medicine (TRM), Laboratory Tumor Immunology, Faculty Medicine,...
Obesity is associated with body fat gain and impaired glucose metabolism. Here, we identified both in obesity metabolism as two independent risk factors for increased serum levels of free fatty acids (FFAs). Since and/or delayed resolution inflammation observed various chronic inflammatory diseases such psoriasis, investigated the impact FFAs on human monocyte‐derived mouse bone marrow‐derived dendritic cell (DCs) functions relevant pathogenesis inflammation. palmitic acid (PA) oleic (OA)...