A5054350102- Phagocytosis and Immune Regulation
- Adipokines, Inflammation, and Metabolic Diseases
- COVID-19 Clinical Research Studies
- Erythrocyte Function and Pathophysiology
- Blood properties and coagulation
- Acute Myocardial Infarction Research
- Metal complexes synthesis and properties
- Systemic Lupus Erythematosus Research
- Inorganic and Organometallic Chemistry
- Cell death mechanisms and regulation
- T-cell and B-cell Immunology
- SARS-CoV-2 and COVID-19 Research
- Immune Cell Function and Interaction
- Dermatological and COVID-19 studies
- Inflammasome and immune disorders
- Immunotherapy and Immune Responses
- Pancreatitis Pathology and Treatment
- Immune Response and Inflammation
- Cardiac Fibrosis and Remodeling
- Covalent Organic Framework Applications
- Immune cells in cancer
- Cardiovascular Effects of Exercise
- PARP inhibition in cancer therapy
- Synthesis of Tetrazole Derivatives
- Lipoproteins and Cardiovascular Health
Charité - Universitätsmedizin Berlin
2013-2024
Pentracor (Germany)
2019-2024
DIAKO
2019-2021
Friedrich-Alexander-Universität Erlangen-Nürnberg
2004-2018
Ain Shams University
2018
Madras Medical Mission
2018
Bayer (Italy)
2017
University of Otago
2010
Universitätsklinikum Erlangen
2007
LaVision (Germany)
2007
Most patients who became critically ill following infection with COVID-19 develop severe acute respiratory syndrome (SARS) attributed to a maladaptive or inadequate immune response. The complement system is an important component of the innate that involved in opsonization viruses but also triggering further cell responses. Complement activation was seen plasma adsorber material clogged during treatment COVID-19. Apart from lung, kidney second most common organ affected by Using...
Background: C-reactive protein (CRP) is a well-known marker of inflammation. It less known that CRP mediates tissue damage in acute myocardial infarction (AMI) thus potentially worsening prognosis. A newly developed specific adsorber allows efficient lowering levels and may improve survival. Objectives: Aim this multi-center, controlled, non-randomized first-in-man apheresis Acute Myocardial Infarction study (CAMI-1) was to investigate the relationship between (CRP gradient), infarct size...
There is growing evidence that inflammation plays a pivotal role in the etiology and progression of atherosclerosis. High C-reactive protein (CRP) levels have been associated with high mortality patients acute myocardial infarction (AMI). Furthermore, animal models CRP has found to significantly increase infarct size. So there not only marker for cardiovascular disease but also might be pathogenic. The aim our study was test hypothesis peak could predict heart failure (HF) ST-elevation...
Background: There is substantial evidence that C-reactive protein (CRP) mediates secondary damage of the myocardium after acute myocardial infarction (AMI). The aim this animal trial in pigs was to specifically deplete CRP from porcine plasma AMI and study possible beneficial effects reduced concentration on infarcted area. Methods: Ten received balloon catheter-induced infarction. depleted five animals utilizing a new specific CRP-adsorber, served as controls. area analyzed by...
C-reactive protein (CRP) has long been identified as a potential therapeutic target to improve outcomes in acute myocardial infarction (AMI). Recently, CRP apheresis shown promising results from first-in-human case reports, registries, and pilot trials patients with COVID-19, ST-segment elevation infarction, cardiogenic shock, non-ST-segment coronary syndromes. Herein we describe the perspective for pivotal, international, randomized controlled trial investigating AMI. We herein propose...
Abstract C‐reactive protein (CRP), the prototype human acute‐phase protein, is a well‐known marker of inflammation. However, CRP may also mediate tissue damage in various diseases like atherosclerosis, acute myocardial infarction, dilated cardiomyopathy, stroke, and potentially autoimmune disease. Therefore, elimination from plasma indeed be widely usable therapeutic approach. Recently, first‐in‐man case report selective CRP‐apheresis patient with ST‐segment elevation infarction (STEMI) has...
Mechanisms governing the normal resolution processes of inflammation are poorly understood, yet their elucidation may lead to a greater understanding pathogenesis chronic inflammation. The removal apoptotic cell material and potentially histotoxic contents is prerequisite resolution. Engulfment by macrophages an important disposal route, changes in cells that associated with recognition subject this report.Apoptosis necrosis primary lines were induced various stimuli. binding profile 23...
BACKGROUND:C-reactive protein (CRP) plasma levels in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel viral disease, are surprisingly high. Pulmonary inflammation with subsequent fibrosis SARS-CoV-2 infection is strongly accelerated. Recently, we have developed CRP apheresis to selectively remove from human plasma. may contribute organ failure and pulmonary by CRP-mediated complement macrophage activation. CASE REPORT:A 72-year-old male patient at high risk was referred...
Apoptotic and necrotic cells expose phosphatidylserine (PS). This membrane modification ensures a swift recognition uptake by phagocytes of the dying dead cells. Annexin V (AxV) preferentially binds to anionic phospholipids thereby, modulates clearance process. First, we analyzed influence AxV on immunogenicity apoptotic The addition prior their injection into mice increased significantly. Next, studied endogenous allogeneic reaction against To preserve heat-labile, short-lived "danger...
Systemic lupus erythematosus (SLE) is a chronic inflammatory disease characterized by the production of autoantibodies, formation immune complexes (IC), and activation complement that ultimately fuel acute and/or inflammation. Accumulation in blood tissues post-apoptotic remnants considered etiological pathological importance for patients with SLE. Besides receptors directly recognizing apoptotic cells, soluble opsonins innate system bind material dependent on stage apoptosis. We describe...
Glaucoma is a frequent ocular disease that may lead to blindness. Primary open-angle glaucoma (POAG) and hypertension (OHT) are common diseases with increased intraocular pressure, which mainly responsible for these disorders. Their pathogenesis widely unknown. We screened the sera of patients POAG OHT prevalence autoantibodies (AAb) against G protein coupled receptors (GPCRs) in comparison controls. Employing frequency modulation spontaneously contracting neonatal rat cardiomyocytes vitro,...
C-reactive protein (CRP) is well known as a general marker of inflammation. It furthermore represents reliable risk factor for cardiac events and mediates tissue damage in acute myocardial infarction (AMI). has been demonstrated that selective CRP depletion by extracorporeal apheresis porcine AMI model had beneficial effects on the infarcted area output. We therefore developed novel adsorber from human plasma (PentraSorb CRP). intended use clinic therapy patients suffering or other...
Background Plasma levels of C-reactive protein (CRP), induced by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) triggering COVID-19, can rise surprisingly high. The increase the CRP concentration as well a certain threshold are indicative clinical deterioration to artificial ventilation. In virus-induced lung injury and subsequent massive onset inflammation often drives pulmonary fibrosis. Fibrosis usually proceeds sequela severe course COVID-19 its consequences only show...
ABSTRACT Monoclonal antibodies (mAbs) contain short N‐terminal signal peptides on each individual polypeptide that comprises the mature antibody, targeting them for export from cell in which they are produced. The peptide is cleaved heavy chain (Hc) and light (Lc) after translocation to ER prior secretion. This process generally highly efficient, producing a high proportion of correctly Hc Lc polypeptides. However, mis‐cleavage can occur, resulting truncation or elongation at N‐terminus Lc....