A5102752514- Receptor Mechanisms and Signaling
- Neuropeptides and Animal Physiology
- Proteoglycans and glycosaminoglycans research
- Chemokine receptors and signaling
- Wound Healing and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Wnt/β-catenin signaling in development and cancer
- Immune cells in cancer
- Hedgehog Signaling Pathway Studies
- Ion Channels and Receptors
- Pharmacological Effects and Toxicity Studies
- Pressure Ulcer Prevention and Management
- Metabolism and Genetic Disorders
- Antimicrobial Peptides and Activities
- Fibroblast Growth Factor Research
- Pancreatic function and diabetes
- Epigenetics and DNA Methylation
- Genetic and rare skin diseases.
- Neurological and metabolic disorders
- Dermatologic Treatments and Research
Leipzig University
2006-2018
Glycosaminoglycan-based hydrogels scavenge proinflammatory chemokines, reduce the influx of immune cells, and improve healing chronic wounds.
Leukocyte recruitment in response to inflammatory signals is governed, part, by binding Thy-1 (CD90) on activated endothelial cells (EC). In this study, we characterized the adhesion G-protein coupled receptor CD97, present peripheral myeloid cells, as a novel interacting partner for Thy-1. CD97 was upregulated polymorphonuclear (PMNC) of patients with psoriasis. psoriatic skin lesions, CD97(+) colocalized Thy-1(+) EC small vessels microabscesses, suggesting an interaction between and that...
Abstract The heptahelical receptor CD97 is a defining member of the EGF-TM7 family adhesion class receptors. In both humans and mice, isoforms are expressed with variable numbers tandemly arranged N-terminal epidermal growth factor-like domains that facilitate interactions distinct cellular ligands. Results from treatment mice mAbs in various disease models have suggested role for leukocyte trafficking. Here, we aimed to thoroughly characterize expression profile CD97, delineate its...
The adhesion G-protein-coupled receptor CD97 is present in normal colonic enterocytes but overexpressed colorectal carcinoma. To investigate the function of carcinogenesis, transgenic Tg(villin-CD97) mice overexpressing were generated and subjected to azoxymethane (AOM)/dextran sodium sulfate (DSS)-induced colitis-associated tumorigenesis. Unexpectedly, we found a cDNA copy number-dependent reduction DSS-induced colitis Tg compared wild-type (WT) that was confirmed by applying simple DSS...
It is well recognized that high molecular weight hyaluronan (H‐HA) exerts potent anti‐inflammatory effects while its fragmentation into low HA (L‐HA) discussed to promote inflammation. Chemical modification of with sulfate groups has been shown foster activity which seems be maintained in sulfated derivatives (sL‐HA). However, the mechanisms by sL‐HA produces are not understood. In this study, we used global quantitative proteomics combined targeted analysis key proteins characterize effect...
The adhesion G protein-coupled receptor CD97/ADGRE5 is present in adherens junctions of human normal intestinal cells and upregulated colorectal carcinomas. Here, we examined whether CD97 directly interacts with junctional proteins malignant tissue. We identified an association β-catenin using a proximity ligation assay confirmed the interaction between both endogenous at biochemical level by co-immunoprecipitation mouse tissues cell lines. GST-pulldown revealed that binds through its...
Event Abstract Back to StarPEG-heparin hydrogels as chemokine scavenger improve aberrant wound healing processes Nadine Lohmann1, 2, Lucas Schirmer2, 3, Elke Wandel1, Passant Atallah2, Inka Forstreuter1, Uwe Freudenberg2, Carsten Werner2, Jan C. Simon1, 2 and Sandra Franz1, 1 Leipzig University, Department of Dermatology, Venerology Allergology, Germany SFB-TRR67, Collaborative Research CenterMatrixengineering, 3 Center for Regenerative Therapies Dresden, Leibnitz Institute Polymer New ECM...