A5054291623- Endometrial and Cervical Cancer Treatments
- Cervical Cancer and HPV Research
- Ovarian cancer diagnosis and treatment
- Uterine Myomas and Treatments
- Colorectal and Anal Carcinomas
- Gestational Trophoblastic Disease Studies
- Endometriosis Research and Treatment
- Genital Health and Disease
- Sarcoma Diagnosis and Treatment
- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
- Prenatal Screening and Diagnostics
- Cancer, Hypoxia, and Metabolism
- Prostate Cancer Diagnosis and Treatment
- Urologic and reproductive health conditions
- Cancer and Skin Lesions
- Ectopic Pregnancy Diagnosis and Management
- Urological Disorders and Treatments
- Prostate Cancer Treatment and Research
- Urinary Bladder and Prostate Research
- Cancer Diagnosis and Treatment
- MRI in cancer diagnosis
- Cancer Cells and Metastasis
- Genetic factors in colorectal cancer
- Radiomics and Machine Learning in Medical Imaging
University Hospital Leipzig
2016-2025
Leipzig University
2015-2025
Medizinische Hochschule Hannover
2022
University of Gothenburg
2021
University Hospital Regensburg
2021
Barts Health NHS Trust
2018-2019
Belfast Health and Social Care Trust
2017-2019
University of British Columbia
2019
Royal Derby Hospital
2019
Walsall Healthcare NHS Trust
2019
Abstract The 2020 WHO classification is focused on the distinction between HPV-associated and HPV-independent squamous cell carcinoma of lower female genital organs. Differentiating according to HPV association does not replace process grading; however, recommend any specific grading system. VIN are also differentiated whether they HPV(p16)-associated. adenocarcinoma (AC) cervix uteri has an unfavorable prognosis. Immunohistochemical p16 expression considered be a surrogate marker for...
Although endometrial carcinoma (EC) is generally considered to have a good prognosis, over 20% of women with EC die their disease, projected increase in both incidence and mortality the next few decades. The aim accurate prognostication ensure that patients receive optimal treatment are neither overtreated nor undertreated, thereby improving patient outcomes overall. Patients can be categorized into prognostic risk groups based on clinicopathologic findings. Other than tumor type grade,...
Tissue, cell, and nucleus morphology change during tumor progression. In 2D confluent cell cultures, different tissue states, such as fluid (unjammed) solid (jammed), are correlated with shapes. These results do not have to apply a priori three dimensions. Cancer motility requires corresponds fluidization of the on bulk level. Here, we investigate fluidity in 3D determine how it correlates shape. patient samples mamma cervix carcinoma, find areas where cells can move or immobile. We compare...
In most cases, the endometrioid adenocarcinoma of endometrium is preceded by hyperplasia with different risk progression into carcinoma. The original histologic slides from 560 consecutive cases complex and atypical were re-examined to assess interobserver-correlation. hyperplasias analyzed separately for their likelihood carcinoma in patients without progestogen hormonal therapy. all a fractional re-curreting was performed establish state disease. leading symptom vaginal bleeding 65.5%...
The quality of cervical histopathology is critical to cancer prevention, treatment, and research programs. On the basis histology results further patient management determined. However, diagnostic interpretation histologic hematoxylin-eosin (H&E)-stained slides affected by substantial rates discordance among pathologists. Overexpression cyclin-dependent kinase inhibitor p16INK4a, a cell cycle regulating protein, has been shown be strongly correlated with dysplastic lesions cervix uteri. In...
Abstract Hypoxia is now established as a key factor influencing the pathophysiology of malignant growth. Among other effects, hypoxia modulates expression multitude genes through induction hypoxia-inducible transcription factors. This differential gene favors angiogenesis, cell survival, an invasive/metastatic phenotype, and resistance to anticancer therapies. Because benign tumors do not exhibit these traits, one might expect entities be neither hypoxic nor induce genetic response program....
Endometrial cancer is the most common gynecologic neoplasm in developed countries; however, updated universal guidelines are currently not available to handle specimens obtained during surgical treatment of patients affected by this disease. This article presents recommendations on how gross and submit sections for microscopic examination hysterectomy other tissues removed management endometrial such as salpingo-oophorectomy, omentectomy, lymph node dissection—including sentinel nodes. In...
Purpose: This is an official guideline, published and coordinated by the Arbeitsgemeinschaft Gynäkologische Onkologie (AGO, Study Group for Gynecologic Oncology) of Deutsche Krebsgesellschaft (DKG, German Cancer Society) Gesellschaft für Gynäkologie und Geburtshilfe (DGGG, Society Gynecology Obstetrics). The number cases with vulvar cancer on rise, but because former rarity this condition resulting lack literature a high level evidence, in many areas knowledge optimal clinical management...
Abstract Aims The aim of this official guideline published and coordinated by the German Society Gynaecology Obstetrics (DGGG) in cooperation with Austrian for (OEGGG) Swiss (SGGG) was to provide consensus-based recommendations diagnosis treatment endometriosis based on an evaluation relevant literature. Methods This S2k represents structured consensus a representative panel experts different professional backgrounds commissioned Guideline Committee DGGG, OEGGG SGGG. Recommendations...
Dysplastic lesions of the vagina or vulva often occur in women who have a previous history cervical dysplasia. Most female lower genital tract are induced by infections with high-risk oncogenic human papillomaviruses (HR-HPVs), including HPV16 and HPV18. HR-HPV genomes frequently integrate into host cell chromosomes at random sites. We analyzed viral integration sites multiple metachronous from previously treated for HR-HPV-positive dysplasia cancer to determine whether emerged single common...