A5105520160- Particle physics theoretical and experimental studies
- High-Energy Particle Collisions Research
- Particle Detector Development and Performance
- Quantum Chromodynamics and Particle Interactions
- Dark Matter and Cosmic Phenomena
- Computational Physics and Python Applications
- Neutrino Physics Research
- Cosmology and Gravitation Theories
- Distributed and Parallel Computing Systems
- Radiation Detection and Scintillator Technologies
- Cellular Mechanics and Interactions
- Medical Imaging Techniques and Applications
- Cancer Cells and Metastasis
- Advanced Radiotherapy Techniques
- Advanced Data Storage Technologies
- Microfluidic and Bio-sensing Technologies
- 3D Printing in Biomedical Research
- Atomic and Subatomic Physics Research
- Nuclear Physics and Applications
- Astrophysics and Cosmic Phenomena
- Superconducting Materials and Applications
- Big Data Technologies and Applications
- Radiation Therapy and Dosimetry
- Radioactive Decay and Measurement Techniques
- Cell Image Analysis Techniques
Deutsches Elektronen-Synchrotron DESY
2023-2025
Fermi National Accelerator Laboratory
2024
University of Chicago
2024
European Organization for Nuclear Research
2023-2024
University of California, Santa Cruz
2023-2024
A. Alikhanyan National Laboratory
2024
Atlas Scientific (United States)
2024
Leipzig University
2021-2023
The University of Adelaide
2023
Max Planck Institute for Physics
2023
Tissue, cell, and nucleus morphology change during tumor progression. In 2D confluent cell cultures, different tissue states, such as fluid (unjammed) solid (jammed), are correlated with shapes. These results do not have to apply a priori three dimensions. Cancer motility requires corresponds fluidization of the on bulk level. Here, we investigate fluidity in 3D determine how it correlates shape. patient samples mamma cervix carcinoma, find areas where cells can move or immobile. We compare...
Pathological morphological changes in tumor tissue enable collective cancer cell unjamming, a cellular motility transition. However, fundamental questions remain: Is unjamming essential for progression? Which different states can be found patients? Here, vital tracking patient-derived solid explants (N=16) reveals that of recognized by elongated and nucleus shape (CeNuS) low number density. These static variables serve as morphodynamic link to map the broad range morphologies associated...
This work presents a detailed description of measuring devices and calibration procedures which enable the nondestructive (non-intercepting) absolute measurement charge individual beam pulses (macro-pulses) from an electron linear accelerator traceable to primary standards with high accuracy, i.e. expanded uncertainty < 0.1%. In particular, we demonstrate readout Bergoz integrating current transformer is frequently applied at many different types accelerators as intensity monitor. The signal...
There is a need to verify the accuracy of general purpose Monte Carlo codes like EGSnrc, which are commonly employed for investigations dosimetric problems in radiation therapy. A number experimental benchmarks have been published compare calculated values absorbed dose experimentally determined values. However, there lack absolute benchmarks, i.e. without involved normalization may cause some quantities be cancelled. Therefore, at Physikalisch-Technische Bundesanstalt benchmark experiment...
At the national metrology institute of Germany, Physikalisch-Technische Bundesanstalt, a research accelerator for dosimetry in radiation therapy has been installed. Magnetic spectrometry is used to determine spectrum high-energy electrons generated by this accelerator. Regarding intended experiments at accelerator, high accuracy energy determination electron beam required. For purpose, an experimental setup that number additional devices assembled around spectrometer geometric...
Abstract Distant metastasis is the most lethal hallmark of cancer. Nevertheless, due to a lack suitable markers, emerging motility cancer cells only has negligible impact on current diagnosis and prognosis. In clusters solid tumours, cooperative unjamming transitions generate regions unjammed motile cells, as we could show by vital cell tracking in patient-derived tumour explants. Thereby, their nuclei collectively deform/elongate squeeze past each other. The cells' differing shapes...
Abstract Palpation, as already mentioned in the ancient Egyptian medical text Ebers Papyrus, utilizes that solid tumors are stiffer than surrounding tissue. However, cancer cell lines tend to soften, which may intuitively foster invasion by enhancing ability of cells squeeze through dense This paradox raises questions besides oxymoron itself: Does softness emerge from adaptation external microenvironment? Or soft present inside a rigid primary tumor mass support unjamming? We investigate...