Stefanie Burghaus
A5010134282- Endometriosis Research and Treatment
- Uterine Myomas and Treatments
- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Reproductive System and Pregnancy
- Gynecological conditions and treatments
- Renal and related cancers
- Medical and Health Sciences Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Renal cell carcinoma treatment
- Cancer-related molecular mechanisms research
- Medical Practices and Rehabilitation
- Mobile Health and mHealth Applications
- Genetic Associations and Epidemiology
- Maternal Mental Health During Pregnancy and Postpartum
- Omental and Epiploic Conditions
- BRCA gene mutations in cancer
- Child Development and Digital Technology
- Coffee research and impacts
- RNA modifications and cancer
- Testicular diseases and treatments
- Assisted Reproductive Technology and Twin Pregnancy
- Adrenal and Paraganglionic Tumors
- Birth, Development, and Health
- Maternal and fetal healthcare
Friedrich-Alexander-Universität Erlangen-Nürnberg
2015-2024
Universitätsklinikum Erlangen
2014-2024
Olgahospital
2022
Stuttgart Observatory
2021
FH Aachen
2021
TU Dresden
2021
Comprehensive Cancer Center Erlangen
2015-2020
Background:In vitro and observational epidemiological studies suggest that vitamin D may play a role in cancer prevention. However, the relationship between ovarian is uncertain, with generating conflicting findings. A potential limitation of inadequate control confounding. To overcome this problem, we used Mendelian randomization (MR) to evaluate association single nucleotide polymorphisms (SNPs) associated circulating 25-hydroxyvitamin [25(OH)D] concentration risk cancer. Methods: We...
Epidemiological studies have demonstrated associations between endometriosis and certain histotypes of ovarian cancer, including clear cell, low-grade serous endometrioid carcinomas. We aimed to determine whether the observed might be due shared genetic aetiology. To address this, we used two datasets genotyped on common arrays with full-genome coverage (3194 cases 7060 controls) a large cancer dataset customized Illumina Infinium iSelect (iCOGS) (10 065 21 663 controls). Previous work has...
Abstract Aims The aim of this official guideline published and coordinated by the German Society Gynaecology Obstetrics (DGGG) in cooperation with Austrian for (OEGGG) Swiss (SGGG) was to provide consensus-based recommendations diagnosis treatment endometriosis based on an evaluation relevant literature. Methods This S2k represents structured consensus a representative panel experts different professional backgrounds commissioned Guideline Committee DGGG, OEGGG SGGG. Recommendations...
To evaluate blood-based biomarkers to detect endometriosis and/or adenomyosis across nine European centers (June 2014-April 2018).This prospective, non-interventional study assessed the diagnostic accuracy of 54 biomarker immunoassays in samples from 919 women (aged 18-45 years) with suspicion versus symptomatic controls. Endometriosis was stratified by revised American Society for Reproductive Medicine stage. Symptomatic controls were "pathologic controls" or "pathology-free controls". The...
<b>Objective:</b> The etiology of endometriosis is still a research field in which few consistent data are available. Large case–control studies or even cohort rare, and most the published conflicting. aim present study was therefore to examine common epidemiological endometriosis-specific risk factors German study. <b>Design:</b> From 2001 2010, pool 595 laparoscopically confirmed cases 475 controls were recruited hospital-based setting. After matching for age, 298 300 remained pool. Age at...
No screening programs are available for ovarian or endometrial cancer. One reason this is the low incidence of conditions, resulting in positive predictive values tests, which not very specific. way addressing problem might be to use risk factors define subpopulations with a higher incidence. The aim study was investigate extent medical history endometriosis can serve as factor cancer.In hospital-based case-control analysis, cases represented patients cancer who were participating studies...
The aim of this study was to investigate whether single nucleotide polymorphisms (SNPs) in genes the stress hormone signaling pathway, specifically FKBP5, NR3C1, and CRHR1, are associated with depressive symptoms during after pregnancy. Franconian Maternal Health Evaluation Study (FRAMES) recruited healthy pregnant women prospectively for assessment maternal fetal health including depressiveness. German version 10-item Edinburgh Postnatal Depression Scale (EPDS) completed at three time...
Even though endometriosis presents one of the most common gynaecological diseases, pathogenesis is insufficiently studied. Besides immunologic, inflammatory or oxidative processes, recent studies also suggest an influence nutrition on disease onset and progression. Because data about actual nutrient intake patients are scarce, we aimed to examine potential influencing factors in these women. A total 156 women with (EM) 52 age-matched controls were included this retrospective case-control...
Uterine leiomyomas (ULs) constitute a considerable health burden in the general female population. The fumarate hydratase (FH) deficient subtype is found up to 1.6% and can occur hereditary leiomyomatosis renal cell carcinoma (HLRCC) syndrome. We sequenced 13 FH ULs from previous immunohistochemical screen using targeted panel identified biallelic variants all. In eight, we an point mutation (two truncating, six missense) with evidence for loss of second allele. Variant allele-frequencies...
Abstract A heuristic tool called “the hallmarks of cancer” helps to reduce the enormous complexity cancer phenotypes and genotypes a preliminary set guiding principles. Other aspects have surfaced as possible improvements in our understanding disease’s mechanisms. Endometriosis is gynecological disease condition negatively impacting quality life many women. To date, there no curative treatment for endometriosis. Therapy aimed at treating symptoms using hormone therapy, pain therapy...
Coffee consumption has been shown to be associated with various health outcomes in observational studies. However, evidence for its association epithelial ovarian cancer (EOC) is inconsistent and it unclear whether these associations are causal. We used single nucleotide polymorphisms (i) coffee (ii) caffeine perform Mendelian randomization (MR) on EOC risk. conducted a two-sample MR using genetic data 44 062 individuals of European ancestry from the Ovarian Cancer Association Consortium...
Daysy is a fertility monitor that uses the awareness method by tracking and analyzing individual menstrual cycle. In addition, can be connected to application DaysyView transfer stored personal data from smartphone or tablet (IOS, Android). This combination interesting because as it shown in various studies, use of apps increasing patients´ focus on their disease health behavior. The aim this study was investigate if additional an App thereby improved usability medical device, possible...
Endometriosis is one of the most common benign gynecological diseases. The extremely heterogeneous complex symptoms complicates diagnosis and treatment this disease. In patients, there a latency period several years between first occurrence definitive diagnosis. This paper aims (1) to evaluate standards for patients with (symptoms suspicious for) endometriosis in terms feasibility, (2) assess potential use data collected by certified clinical scientific center answer questions. Standards...
Endometriosis is a heterogeneous disease characterized by range of different presentations. It usually diagnosed when patients present with pain and/or infertility, but it has also been in asymptomatic patients. Because the diagnostic approaches and diverse therapies, time to diagnosis can vary considerably definitive may be delayed, some cases not being for several years. have many unmet needs. A systematic registration follow-up endometriosis could useful obtain an insight into course...
Endometriosis is a chronic disease of women in the reproductive age, defined as endometrial cells growing outside uterine cavity and associated with relapses. Relapses are hypothesized to correlate incomplete surgical excision or result from nonrandom implantation new implants adjacent peritoneum. Thus, could lead free endometriotic tissue residues, which readhere, grow, invade into recurrent lesions. Barrier agents frequently used prevent postoperative adhesions. We tested if absorbable...