Anja Rudolph
A5078331202- BRCA gene mutations in cancer
- Genetic Associations and Epidemiology
- Nutrition, Genetics, and Disease
- Genetic factors in colorectal cancer
- Ovarian cancer diagnosis and treatment
- Estrogen and related hormone effects
- Cancer-related molecular mechanisms research
- Cancer Risks and Factors
- Bioinformatics and Genomic Networks
- Genomics and Chromatin Dynamics
- Breast Cancer Treatment Studies
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- Gene expression and cancer classification
- Nutritional Studies and Diet
- Genomic variations and chromosomal abnormalities
- Cancer Immunotherapy and Biomarkers
- CRISPR and Genetic Engineering
- Cancer, Lipids, and Metabolism
- Genetics, Bioinformatics, and Biomedical Research
- Glutathione Transferases and Polymorphisms
- Breast Lesions and Carcinomas
- RNA Research and Splicing
- Endometriosis Research and Treatment
Heidelberg University
2010-2023
University Hospital Heidelberg
2015-2023
Fraunhofer Institute for High Frequency Physics and Radar Techniques
2023
German Cancer Research Center
2010-2018
Jena University Hospital
2012-2018
Danish Cancer Society
2013-2016
University College London
2013-2016
University Medical Center Hamburg-Eppendorf
2014-2016
Cancer Research Center
2015-2016
Universität Hamburg
2014-2016
Common variation on 14q24.1, close to RAD51B, has been associated with breast cancer: rs999737 and rs2588809 the risk of female cancer rs1314913 male cancer. The aim this study was investigate role RAD51B variants in predisposition, particularly context familial Finland. We sequenced coding region 168 Finnish patients from Helsinki for identification possible recurrent founder mutations. In addition, we studied known rs999737, rs2588809, SNPs haplotypes 44,791 cases 43,583 controls 40...
Genetic variations, such as single nucleotide polymorphisms (SNPs) in microRNAs (miRNA) or the miRNA binding sites may affect dependent gene expression regulation, which has been implicated various cancers, including breast cancer, and alter individual susceptibility to cancer. We investigated associations between related SNPs cancer risk. First we evaluated 2,196 a case-control study combining nine genome wide association studies (GWAS). Second, further 42 with suggestive evidence for using...
Data for multiple common susceptibility alleles breast cancer may be combined to identify women at different levels of risk. Such stratification could guide preventive and screening strategies. However, empirical evidence genetic risk is lacking. We investigated the value using 77 cancer-associated single nucleotide polymorphisms (SNPs) stratification, in a study 33 673 cases 381 control European origin. tested all possible pair-wise multiplicative interactions constructed 77-SNP polygenic...
Observational epidemiological studies have shown that high body mass index (BMI) is associated with a reduced risk of breast cancer in premenopausal women but an increased postmenopausal women. It unclear whether this association mediated through shared genetic or environmental factors.
The rarity of mutations in PALB2, CHEK2 and ATM make it difficult to estimate precisely associated cancer risks. Population-based family studies have provided evidence that at least some these are with breast risk as high those rare BRCA2 mutations. We aimed the relative risks specific variants via a multicentre case-control study.
IMPORTANCEUse of aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with lower risk colorectal cancer.OBJECTIVE To identify common genetic markers that may confer differential benefit from or NSAID chemoprevention, we tested gene × environment interactions between regular use and/or NSAIDs single-nucleotide polymorphisms (SNPs) in relation to cancer. DESIGN, SETTING, AND PARTICIPANTSCase-control study using data 5 case-control cohort studies initiated 1976 2003...
Abstract Breast, ovarian, and prostate cancers are hormone-related may have a shared genetic basis, but this has not been investigated systematically by genome-wide association (GWA) studies. Meta-analyses combining the largest GWA meta-analysis data sets for these totaling 112,349 cases 116,421 controls of European ancestry, all together in pairs, identified at P < 10−8 seven new cross-cancer loci: three associated with susceptibility to (rs17041869/2q13/BCL2L11;...
Background Tubal ligation is a protective factor for ovarian cancer, but it unknown whether this protection extends to all invasive histological subtypes or borderline tumors. We undertook an international collaborative study examine the association between tubal and cancer subtypes. Methods pooled primary data from 13 population-based case-control studies, including 10 157 patients with (7942 invasive; 2215 borderline) 904 control women. Invasive cases were analysed by type, grade stage,...
CHEK2*1100delC is a well-established breast cancer risk variant that most prevalent in European populations; however, there are limited data on of by age and tumor subtype, which limits its usefulness prediction. We aimed to generate subtype- age-specific estimates using from the Breast Cancer Association Consortium, including 44,777 patients with 42,997 controls 33 studies genotyped for CHEK2*1100delC.
Various common genetic susceptibility loci have been identified for breast cancer; however, it is unclear how they combine with lifestyle/environmental risk factors to influence risk. We undertook an international collaborative study assess gene-environment interaction of cancer. Data from 24 studies the Breast Cancer Association Consortium were pooled. Using up 34,793 invasive cancers and 41,099 controls, we examined whether relative risks associated 23 single nucleotide polymorphisms...
Triple-negative (TN) breast cancer is an aggressive subtype of associated with a unique set epidemiologic and genetic risk factors. We conducted two-stage genome-wide association study TN (stage 1: 1529 cases, 3399 controls; stage 2: 2148 1309 controls) to identify loci that influence risk. Variants in the 19p13.1 PTHLH showed significant associations (P < 5 × 10−8) 1 2 combined. Results also suggested substantial enrichment significantly variants among single nucleotide polymorphisms (SNPs)...
Mean telomere length (TL) in blood cells is heritable and has been reported to be associated with risks of several diseases, including cancer. We conducted a meta-analysis three GWAS for TL (total n=2240) selected 1629 variants replication via the "iCOGS" custom genotyping array. All ∼200 000 iCOGS were analysed TL, those displaying associations healthy controls (n = 15 065) further tested breast cancer cases 11 024). found novel association (Ptrend < 4 × 10−10) at 3p14.4 close PXK evidence...
Metastasis is the principal cause of high morbidity and mortality among breast cancer (BC) patients. Identification markers that can be routinely monitored to predict onset metastasis in BC patients prognosis metastatic (MBC) would increase their median survival. In this study, plasma miRNAs 40 MBC were profiled by TaqMan low density arrays with prognostic capacity identified. The candidates validated initially samples 237 subsequently 335 from an independent study cohort Sixteen established...
A sizable fraction of colorectal cancer (CRC) is expected to be explained by heritable factors, with heritability estimates ranging from 12 35% twin and family studies. Genome-wide association studies (GWAS) have successfully identified a number common single-nucleotide polymorphisms (SNPs) associated CRC risk. Although it has been shown that these susceptibility SNPs only explain small proportion the genetic risk, not clear how much left detected other, yet identified, SNPs. Therefore, we...
Background:In vitro and observational epidemiological studies suggest that vitamin D may play a role in cancer prevention. However, the relationship between ovarian is uncertain, with generating conflicting findings. A potential limitation of inadequate control confounding. To overcome this problem, we used Mendelian randomization (MR) to evaluate association single nucleotide polymorphisms (SNPs) associated circulating 25-hydroxyvitamin [25(OH)D] concentration risk cancer. Methods: We...
Abstract Introduction The distribution of histopathological features invasive breast tumors in BRCA1 or BRCA2 germline mutation carriers differs from that individuals with no known mutation. Histopathological thus have utility for prediction, including statistical modeling to assess pathogenicity variants uncertain clinical significance. We analyzed large pathology datasets accrued by the Consortium Investigators Modifiers /2 (CIMBA) and Breast Cancer Association (BCAC) reassess predictors...
Statins have been associated with moderate reductions in mortality among colorectal cancer (CRC) patients, but these studies lacked adjustment for some potentially relevant factors statin use. We aimed to provide more detailed results on this association from a population-based patient cohort study. Use of statins and other risk or protective were assessed standardized interviews 2697 patients southern Germany diagnosis incident CRC between 2003 2009 (Darmkrebs: Chancen der Verhütung durch...