Linetta B. Koppert
A5085458371- Breast Cancer Treatment Studies
- Breast Implant and Reconstruction
- BRCA gene mutations in cancer
- Breast Lesions and Carcinomas
- Global Cancer Incidence and Screening
- Cancer survivorship and care
- Cancer Genomics and Diagnostics
- Esophageal Cancer Research and Treatment
- Health Systems, Economic Evaluations, Quality of Life
- Cancer Risks and Factors
- Genetic Associations and Epidemiology
- Nutrition, Genetics, and Disease
- Clinical practice guidelines implementation
- Cancer Treatment and Pharmacology
- Gastric Cancer Management and Outcomes
- Family Support in Illness
- Nonmelanoma Skin Cancer Studies
- Economic and Financial Impacts of Cancer
- Genetic factors in colorectal cancer
- Cancer Diagnosis and Treatment
- Esophageal and GI Pathology
- HER2/EGFR in Cancer Research
- Reconstructive Surgery and Microvascular Techniques
- Advanced Breast Cancer Therapies
- Cancer-related gene regulation
Erasmus MC Cancer Institute
2015-2024
Erasmus MC
2010-2024
Erasmus University Rotterdam
2012-2024
Rotterdam University of Applied Sciences
2014-2023
University Medical Center
2017-2023
University Hospital and Clinics
2017-2023
Netherlands Comprehensive Cancer Organisation
2017-2023
Wikimedia Nederland
2023
Maastricht University Medical Centre
2023
Maastricht University
2023
Observational epidemiological studies have shown that high body mass index (BMI) is associated with a reduced risk of breast cancer in premenopausal women but an increased postmenopausal women. It unclear whether this association mediated through shared genetic or environmental factors.
A major challenge in value-based health care is the lack of standardized outcomes measurements, hindering optimal monitoring and comparison quality across different settings globally. The International Consortium for Health Outcomes Measurement (ICHOM) assembled a multidisciplinary international working group, comprised 26 providers patient advocates, to develop standard set patient-centered breast cancer (BC). group convened via 8 teleconferences completed follow-up survey after each...
Data on survival of BRCA1/2-associated primary breast cancer (PBC) patients who opt for subsequent contralateral risk-reducing mastectomy (CRRM) are scarce and inconsistent. We examined the efficacy CRRM overall in mutation carriers with a history PBC. From Dutch multicentre cohort, we selected 583 BRCA-associated PBC patients, being diagnosed between 1980 2011. Over time, 242 (42%) underwent 341 (58%) remained under surveillance. Survival analyses were performed using Cox models, as...
In healthy BRCA1/2 mutation carriers, bilateral risk-reducing mastectomy (BRRM) strongly reduces the risk of developing breast cancer (BC); however, no clear survival benefit BRRM over BC surveillance has been reported yet. this Dutch multicenter cohort study, we used multivariable Cox models with as a time-dependent covariable to estimate associations between and overall BC-specific mortality rates, separately for BRCA1 BRCA2 carriers. During mean follow-up 10.3 years, 722 out 1712 (42%)...
Purpose Surgery has curative potential in a proportion of patients with esophageal cancer, but is associated considerable perioperative risks. We aimed to develop and validate simple risk score for surgical mortality that could be applied administrative data. Patients Methods analyzed 3,592 esophagectomy from four cohorts. logistic regression analysis predict occurring within 30 days after 1,327 cancer older than 65 years age, diagnosed between 1991 1996 the linked Surveillance, Epidemiology...
This large population-based study compared breast-conserving surgery with radiation therapy (BCT) mastectomy on (long-term) breast cancer-specific (BCSS) and overall survival (OS), investigated the influence of several prognostic factors. Patients primary T1-2N0-2M0 cancer, diagnosed between 1999 2012, were selected from Netherlands Cancer Registry. We 1999-2005 (long-term outcome) 2006-2012 cohort (contemporary adjuvant systemic therapy). Cause death was derived Statistics (CBS)....
Several less-invasive staging procedures have been proposed to replace axillary lymph node dissection (ALND) after neoadjuvant chemotherapy (NAC) in patients with initially clinically node-positive (cN+) breast cancer, but these may fail detect residual disease. Owing the lack of high-level evidence, it is not yet clear which procedure most optimal ALND.To determine diagnostic accuracy radioactive iodine seed placement axilla sentinel biopsy (RISAS), a targeted procedure.This was...
Demand for nipple- and skin- sparing mastectomy (NSM/SSM) with immediate breast reconstruction (BR) has increased at the same time as indications post-mastectomy radiation therapy (PMRT) have broadened. The aim of Oncoplastic Breast Consortium initiative was to address relevant questions arising this clinically challenging scenario.A large global panel oncologic, oncoplastic reconstructive surgeons, patient advocates oncologists developed recommendations clinical practice in an iterative...
A surgical resection is currently the preferred treatment for esophageal cancer if tumor considered to be resectable without evidence of distant metastases (cT1-3 N0-1 M0). high percentage irradical resections reported in studies using neoadjuvant chemotherapy followed by surgery versus alone and trials which patients are treated with alone. Improvement locoregional control chemoradiotherapy might therefore improve prognosis these patients. We previously that after weekly administrations...
Prophylactic skin-sparing mastectomy (SSM) and nipple-sparing (NSM) both are associated with major risk reduction in women high breast cancer risk. Skin-sparing followed by nipple-areola complex (NAC) reconstruction is standard of care, but NSM increasingly being performed. Preservation the NAC may increase patient satisfaction. Therefore, we measured sensitivity after compared satisfaction as well body image SSM NSM.Women who underwent prophylactic bilateral or immediate implant between...
Abstract Background Major surgery for cancer has become safer, including elderly patients with co-morbidity. The aim of this study was to investigate the association between patient characteristics, resection rates and survival among oesophageal or gastric cancer. Methods prospective Dutch population-based Eindhoven Cancer Registry oesophagogastric cancers diagnosed 1995 2009 studied retrospectively characteristics Logistic regression analysis performed assess likelihood in tumour node...
Genome-wide association studies (GWASs) have revealed increased breast cancer risk associated with multiple genetic variants at 5p12. Here, we report the fine mapping of this locus using data from 104,660 subjects 50 case-control in Breast Cancer Association Consortium (BCAC). With for 3,365 genotyped and imputed SNPs across a 1 Mb region (positions 44,394,495–45,364,167; NCBI build 37), found evidence least three independent signals: strongest signal, consisting single SNP rs10941679, was...