A5081638136- Silicone and Siloxane Chemistry
- Breast Cancer Treatment Studies
- Synthesis and characterization of novel inorganic/organometallic compounds
- Synthetic Organic Chemistry Methods
- Organometallic Complex Synthesis and Catalysis
- Breast Implant and Reconstruction
- Organoboron and organosilicon chemistry
- Inorganic and Organometallic Chemistry
- Chemical Synthesis and Reactions
- Breast Lesions and Carcinomas
- Fluorine in Organic Chemistry
- Cancer Cells and Metastasis
- Synthesis and properties of polymers
- Asymmetric Synthesis and Catalysis
- Cancer Genomics and Diagnostics
- BRCA gene mutations in cancer
- Genetic factors in colorectal cancer
- Chemical Reactions and Mechanisms
- Oxidative Organic Chemistry Reactions
- Surgical site infection prevention
- Immunotherapy and Immune Responses
- Reconstructive Surgery and Microvascular Techniques
- Cyclopropane Reaction Mechanisms
- biodegradable polymer synthesis and properties
- Cardiac, Anesthesia and Surgical Outcomes
University Hospital of Basel
2016-2025
University of Basel
2016-2025
Breast Center
2016-2025
RWTH Aachen University
1998-2024
Friedrich-Alexander-Universität Erlangen-Nürnberg
2023
National Cancer Centre Japan
2022
Bernische Krebsliga
2015
Memorial Sloan Kettering Cancer Center
2011-2012
Johns Hopkins University
2011-2012
Sidney Kimmel Comprehensive Cancer Center
2011
The ability of circulating tumor cells (CTCs) to form clusters has been linked increased metastatic potential. Yet biological features and vulnerabilities CTC remain largely unknown. Here, we profile the DNA methylation landscape single CTCs from breast cancer patients mouse models on a genome-wide scale. We find that binding sites for stemness- proliferation-associated transcription factors are specifically hypomethylated in clusters, including OCT4, NANOG, SOX2, SIN3A, paralleling...
Circulating tumor cells (CTCs) are shed from solid cancers in the form of single or clustered cells, and latter display an extraordinary ability to initiate metastasis. Yet, biological phenomena that trigger shedding CTC clusters a primary cancerous lesion poorly understood. Here, when dynamically labeling breast cancer along progression, we observe majority undergoing hypoxia, while CTCs largely normoxic. Strikingly, find vascular endothelial growth factor (VEGF) targeting leads shrinkage,...
The 18th St Gallen International Breast Cancer Conference held in March 2023, Vienna, Austria, assessed significant new findings for local and systemic therapies early breast cancer with a focus on the evaluation of multimodal treatment options. emergence more effective, innovative agents both preoperative (primary or neoadjuvant) post-operative (adjuvant) settings has underscored pivotal role multidisciplinary approach decision making, particularly when selecting therapy an individual...
Importance Data on oncological outcomes after omission of axillary lymph node dissection (ALND) in patients with breast cancer that downstages from positive to negative neoadjuvant chemotherapy are sparse. Additionally, the best surgical staging technique this scenario is unknown. Objective To investigate sentinel biopsy (SLNB) dual-tracer mapping or targeted (TAD), which combines SLNB localization and retrieval clipped node. Design, Setting, Participants In multicenter retrospective cohort...
Abstract The presence of circulating tumor cell (CTC) clusters is associated with disease progression and reduced survival in a variety cancer types. In breast cancer, preclinical studies showed that inhibitors the Na + /K ATPase suppress CTC block metastasis. Here we conducted prospective, open-label, proof-of-concept study women metastatic where primary objective was to determine whether treatment inhibitor digoxin could reduce mean cluster size. An analysis nine patients treated daily...
To obtain precise information on the optimal time window for surgical antimicrobial prophylaxis.Although perioperative prophylaxis is a well-established strategy reducing risk of site infections (SSI), timing this procedure has yet to be precisely determined. Under today's recommendations, antibiotics may administered within final 2 hours before skin incision, ideally as close incision possible.In prospective observational cohort study at Basel University Hospital we analyzed incidence SSI...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBiological growth on activated carbon: an investigation by scanning electron microscopyWalter Weber, Jr., Massoud Pirbazari, and Gail MelsonCite this: Environ. Sci. Technol. 1978, 12, 7, 817–819Publication Date (Print):July 1, 1978Publication History Published online1 May 2002Published inissue 1 July 1978https://pubs.acs.org/doi/10.1021/es60143a005https://doi.org/10.1021/es60143a005research-articleACS PublicationsRequest reuse permissionsArticle...
Complete lymph node removal through conventional axillary dissection (ALND) has been standard treatment for breast cancer patients almost a century. In the 1990s, however, and in parallel with advent of sentinel (SLN) procedure, ALND came under increasing scrutiny due to its association significant patient morbidity. Several studies have since provided evidence suggest omission ALND, often favor radiation, selected clinically node-negative, SLN-positive patients, thus supporting current...
Abstract Circulating tumour cell (CTC) clusters have been proposed to be major players in the metastatic spread of breast cancer, particularly during advanced disease stages. Yet, it is unclear whether or not they manifest early as their occurrence patients with metastasis-free primary has thoroughly evaluated. In this study, exploiting nanostructured titanium oxide-coated slides for shear-free CTC identification, we detect clustered CTCs curative setting multiple cancer prior surgical...