A5070436002- Cancer Cells and Metastasis
- Wnt/β-catenin signaling in development and cancer
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Cancer-related gene regulation
- 3D Printing in Biomedical Research
- Immunotherapy and Immune Responses
- Cancer-related Molecular Pathways
- RNA Research and Splicing
- RNA Interference and Gene Delivery
- Peptidase Inhibition and Analysis
- Hormonal Regulation and Hypertension
- Kruppel-like factors research
- International Business and FDI
- interferon and immune responses
- Ion Transport and Channel Regulation
- Global trade and economics
- Cancer Research and Treatments
- Pancreatic function and diabetes
- Protease and Inhibitor Mechanisms
- Proteoglycans and glycosaminoglycans research
- Hereditary Neurological Disorders
- Chemokine receptors and signaling
- Genomics and Chromatin Dynamics
- Vasculitis and related conditions
Champalimaud Foundation
2022-2024
Weatherford College
2024
Disco (Germany)
2024
University Hospital of Basel
2019-2023
University of Basel
2019-2023
Friedrich Miescher Institute
2023
Hospital Pedro Hispano
2023
Hospitais da Universidade de Coimbra
2021-2022
Lawrence Berkeley National Laboratory
2011-2015
Universidade do Porto
2009-2013
Plasmon rulers, consisting of pairs gold nanoparticles, allow single-molecule analysis without photobleaching or blinking; however, current plasmon rulers are irreversible, restricting detection to only single events. Here, we present a reversible ruler, comprised coupled nanoparticles linked by aptamer, capable binding individual secreted molecules with high specificity. We show that the target ruler is characterized sensitivity, specificity, and reversibility. Such should enable dynamic...
Matrix metalloproteinases (MMPs) are crucial mediators in sculpting tissue architecture and required for many physiological pathological processes. MMP3 has been shown to regulate branching morphogenesis the mammary gland. Ectopic expression of proteolytically active mouse epithelia triggers supernumerary lateral and, eventually, tumors. Using a three-dimensional collagen-I (Col-1) gel assay that simulates epithelial invasion branching, we show it is hemopexin domain directs these three...
Background: Changes in junctional catenin expression may compromise cadherin-mediated adhesion, increasing cell malignant properties such as invasive and metastatic abilities. Altered of α-, β-, γ- p120-catenin has been reported to be associated with E-cadherin loss or decreased expression, both breast carcinomas cancer lines. Aims Methods: To investigate the subcellular localisation p120- β-catenin a series human carcinomas, correlate it biological markers clinicopathological parameters....
Article19 August 2020Open Access Prevention of dsRNA-induced interferon signaling by AGO1x is linked to breast cancer cell proliferation Souvik Ghosh orcid.org/0000-0003-4152-4460 Computational and Systems Biology, Biozentrum, University Basel, Switzerland Search for more papers this author Joao C Guimaraes Corresponding Author [email protected] orcid.org/0000-0002-1664-472X Manuela Lanzafame Institute Pathology, Hospital Alexander Schmidt Proteomics Core Facility, Afzal Pasha Syed Beatrice...
The development of the mammary gland involves formation a branched arboreal structure resulting from penetration and proliferation epithelial cells into fat pad. invade by remodeling their surrounding extracellular matrix (ECM), which are rich in proteins, glycans such as heparan sulfate proteoglycans (HSPGs). There is increasing literature on how interaction between signaling ECM metalloproteinases (MMPs) relevant to morphogenetic physiological contexts. Here we sought understand...
A genome-wide PiggyBac transposon-mediated screen and a resistance in PIK3CAH1047R-mutated murine tumor model reveal NF1 loss mammary tumors resistant to the phosphatidylinositol 3-kinase α (PI3Kα)-selective inhibitor alpelisib. Depletion of PIK3CAH1047R breast cancer cell lines patient-derived organoid shows that reduces sensitivity PI3Kα inhibition correlates with enhanced glycolysis lower levels reactive oxygen species (ROS). Unexpectedly, antioxidant N-acetylcysteine (NAC) sensitizes...
Abstract Plasticity delineates cancer subtypes with more or less favourable outcomes. In breast cancer, the subtype triple-negative lacks expression of major differentiation markers, e.g., estrogen receptor α (ERα), and its high cellular plasticity results in greater aggressiveness poorer prognosis than other subtypes. Whether itself represents a potential vulnerability cells is not clear. However, we show here that cell can be exploited to differentiate (TNBC). Using high-throughput...
Background : P120‐catenin is a member of the Armadillo protein family, which involved in intercellular adhesion and cell signalling. It directly interacts with classical cadherins juxtamembrane domain contributes for both junction formation its disassembly. Accumulating evidences indicate that p120‐catenin important tumour progression, although role their multiple spliced isoforms regulation cadherin‐mediated malignant cells still not well understood. We investigated expression collection...
Hypothalamic hamartomas are uncommon congenital malformations that present as precocious puberty, gelastic seizures and/or psychiatric disorders. Characteristic changes in MRI scans lead to a diagnosis. Treatment may include surgery or gonadotropin-releasing hormone agonists (GnRHa) depending on clinical manifestations. Here, we describe case of hypothalamic hamartoma diagnosed girl middle childhood, who presented with early development secondary sexual characteristics. Physical examination,...
Abstract The Arthur and Sandra Irving Cancer Immunology Symposium has been created as a platform for established cancer immunologists to mentor trainees young investigators they launch their research career in the field. By sharing different paths success, senior faculty mentors provide an invaluable resource support development of next generation leaders immunology community. This Commentary describes some key topics that were discussed during 2022 symposium: scientific trajectory,...