A5054718110- Cancer Immunotherapy and Biomarkers
- Prostate Cancer Treatment and Research
- Cancer Genomics and Diagnostics
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Pancreatic and Hepatic Oncology Research
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Research Studies
- Cancer, Hypoxia, and Metabolism
- COVID-19 Clinical Research Studies
- Melanoma and MAPK Pathways
- Renal cell carcinoma treatment
- Medical Imaging and Pathology Studies
- Lung Cancer Treatments and Mutations
- Long-Term Effects of COVID-19
- CAR-T cell therapy research
- Polyomavirus and related diseases
- Genetic and Kidney Cyst Diseases
- SARS-CoV-2 and COVID-19 Research
- Renal and related cancers
- Molecular Biology Techniques and Applications
- Genetic factors in colorectal cancer
- T-cell and B-cell Immunology
- Immune cells in cancer
- AI in cancer detection
University Hospital of Basel
2016-2025
Theological Seminary Bienenberg
2012-2024
Hospital Base
2016-2024
University of Basel
2020-2024
Psychiatry Baselland
2013-2024
Hospital Base
2024
University of Alabama at Birmingham
2023
Kantonsspital Baselland
2012-2023
Providence Pediatric Pulmonology & Cystic Fibrosis
2023
Taipei Institute of Pathology
2021
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has rapidly evolved into a sweeping pandemic. Its major manifestation is in the tract, and general extent of organ involvement microscopic changes lungs remain insufficiently characterised. Autopsies are essential to elucidate COVID-19-associated alterations.This article reports autopsy findings 21 COVID-19 patients hospitalised at University Hospital Basel Cantonal Baselland,...
Abstract Recent insights into the role of von-Hippel Lindau (VHL) tumor suppressor gene in hereditary and sporadic clear-cell renal cell carcinoma (ccRCC) have led to new treatments for patients with metastatic ccRCC, although virtually all eventually succumb disease. We performed an integrated, genome-wide analysis copy-number changes expression profiles 90 tumors, including both VHL disease-associated hopes identifying therapeutic targets ccRCC. identified 14 regions nonrandom change, 7...
BackgroundThe majority of prostate cancers harbor gene fusions the 5′-untranslated region androgen-regulated transmembrane protease serine 2 (TMPRSS2) promoter with erythroblast transformation–specific transcription factor family members. The common fusion between TMPRESS2 and v-ets erythroblastosis virus E26 oncogene homolog (avian) (ERG) is associated a more aggressive clinical phenotype, implying existence distinct subclass cancer defined by this fusion.
Abstract Tumor associated inflammation predicts response to immune checkpoint blockade in human melanoma. Current theories on regulation of center anti-tumor T cell responses. Here we show that tumor B cells are vital melanoma inflammation. Human express pro- and anti-inflammatory factors differentiate into plasmablast-like when exposed autologous secretomes vitro. This phenotype can be reconciled melanomas where also cell-recruiting chemokines CCL3, CCL4, CCL5. Depletion patients by...
Abstract Coronavirus Disease 19 (COVID-19) is a respiratory disease caused by severe acute syndrome coronavirus 2 (SARS-CoV-2), which has grown to worldwide pandemic with substantial mortality. Immune mediated damage been proposed as pathogenic factor, but immune responses in lungs of COVID-19 patients remain poorly characterized. Here we show transcriptomic, histologic and cellular profiles post mortem ( n = 34 tissues from 16 patients) normal lung 9 6 patients). Two distinct...
<h3>Background</h3> Immune checkpoint inhibitors targeting cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and programmed cell death 1 (PD-1) have been recently approved for treatment of patients with metastatic melanoma non-small lung cancer (NSCLC). Despite important clinical benefits, these therapies are associated a diverse spectrum immune-related adverse events (irAEs) that typically transient, but occasionally severe or even fatal. <h3>Case presentation</h3> This autopsy case...
Obesity, characterized by chronic low-grade inflammation of the adipose tissue, is associated with adverse coronavirus disease 2019 (COVID-19) outcomes, yet underlying mechanism unknown. To explore whether severe acute respiratory syndrome 2 (SARS-CoV-2) infection tissue contributes to pathogenesis, we evaluated COVID-19 autopsy cases and deeply profiled response SARS-CoV-2 in vitro. In cases, identified RNA adipocytes an inflammatory infiltrate. We two distinct cellular targets infection: a...
Abstract Purpose: More than 1,300,000 prostate needle biopsies are done annually in the United States with up to 16% incidence of isolated high-grade prostatic intraepithelial neoplasia (HGPIN). HGPIN has low predictive value for identifying cancer on subsequent prostate-specific antigen–screened populations. In contemporary series, is detected ∼20% repeat following a diagnosis HGPIN. Further, discrete histologic subtypes clinical implication management have not been characterized. The...
<h3>Objective</h3> Inflammatory bowel diseases (IBD) have been intrinsically linked to a deregulated cytokine network, but novel therapeutic principles are urgently needed. Here we identify the interleukin (IL)-33 and its receptor ST2 as key negative regulators of wound healing permeability in colon mice. <h3>Design</h3> Expression IL-33 was determined by qRT-PCR, ELISA, immunohistochemistry western-blot analysis. Wild-type <i>St2</i><sup>−/−</sup> mice were used experiments two experimental...
Recent studies have established that a significant fraction of prostate cancers harbor signature gene fusion between the 5' region androgen-regulated TMPRSS2 and an ETS family transcription factor, most commonly ERG. Studies on molecular mechanisms functional consequences this important chromosomal rearrangement are currently limited to VCaP cell line derived from vertebral bone metastasis hormone-refractory tumor. Here we report NCI-H660 line, metastatic site extrapulmonary small carcinoma...
Since the outbreak of coronavirus disease 2019 (COVID-19), there has been a debate whether pregnant women are at specific risk for COVID-19 and it might be vertically transmittable through placenta. We present series five placentas SARS 2 (SARS-CoV-2)-positive who had diagnosed with mild symptoms or asymptomatic before birth. provide detailed histopathologic description morphological changes accompanied by an analysis presence SARS-CoV-2 in placental tissue. All were term deliveries (40th...
Acute kidney injury (AKI) and chronic diseases are associated with high mortality morbidity. Although the underlying mechanisms determining transition from acute to not completely understood, immune-mediated processes critical in renal injury. We have performed a comparison of 2 mouse models leading either regeneration or fibrosis. Using global gene expression profiling we could identify immune-related pathways accounting for majority observed transcriptional changes during Unbiased...
In non-small cell lung cancer (NSCLC), immune checkpoint inhibitors (ICIs) significantly improve overall survival (OS). Tumor mutational burden (TMB) has emerged as a predictive biomarker for patients treated with ICIs. Here, we evaluated the power of TMB measured by Oncomine™ Mutational Load targeted sequencing assay in 76 NSCLC was assessed retrospectively receiving ICI therapy. Clinical data (RECIST 1.1) were collected and classified having either durable clinical benefit (DCB) or no...
There is increasing evidence that tertiary lymphoid structures (TLS) control not only local adaptive B cell responses at melanoma tumor sites but also the cellular composition and function of other immune cells. In human melanoma, however, a comprehensive analysis TLS phenotypes, density spatial distribution different disease stages lacking. Here we used 7-color multiplex immunostaining whole tissue sections from 103 samples to characterize phenotypes along expression established...
Abstract The TMPRSS2–ETS fusion prostate cancers comprise 50–70% of the prostate‐specific antigen (PSA)‐screened hospital‐based examined to date, making it perhaps most common genetic rearrangement in human cancer. variant involves androgen‐regulated TMPRSS2 and ERG , both located on chromosome 21. Emerging data from our group others suggests that TMPRSS2–ERG cancer is associated with higher tumour stage cancer‐specific death. goal this study was determine if somatic alteration a...
Colorectal cancer (CRC) develops through a multistep process and is modulated by inflammation. However, the inflammatory pathways that support intestinal tumors at different stages remain incompletely understood. Interleukin (IL)-33 signaling plays role in inflammation, yet its contribution to pathogenesis of CRC unknown.Using immunohistochemistry on 713 resected human specimens, we show here IL-33 receptor ST2 are expressed low-grade early-stage CRCs, lesser extent higher-grade more...