A5008614237- Prostate Cancer Treatment and Research
- Bladder and Urothelial Cancer Treatments
- Epigenetics and DNA Methylation
- Urinary and Genital Oncology Studies
- Prostate Cancer Diagnosis and Treatment
- Brain Metastases and Treatment
- RNA modifications and cancer
- Infectious Disease Case Reports and Treatments
- Cancer Cells and Metastasis
- Radiopharmaceutical Chemistry and Applications
- Cancer Genomics and Diagnostics
- Cancer Research and Treatments
- Glycogen Storage Diseases and Myoclonus
- Eosinophilic Esophagitis
- Lysosomal Storage Disorders Research
- Immune Cell Function and Interaction
- Gastrointestinal disorders and treatments
- Medical Imaging Techniques and Applications
- Helicobacter pylori-related gastroenterology studies
- IL-33, ST2, and ILC Pathways
- Skin Diseases and Diabetes
- Genetic factors in colorectal cancer
- PARP inhibition in cancer therapy
- Immunotherapy and Immune Responses
- Urologic and reproductive health conditions
University of Bern
2015-2024
University Hospital of Bern
2016-2024
University of Trento
2022
Taipei Institute of Pathology
2019
John Radcliffe Hospital
2018
University of Oxford
2018
Douglas College
2017
University Hospital Galway
2017
Abstract Therapy resistance and metastatic processes in prostate cancer (PCa) remain undefined, due to lack of experimental models that mimic different disease stages. We describe an androgen-dependent PCa patient-derived xenograft (PDX) model from treatment-naïve, soft tissue metastasis (PNPCa). RNA whole-exome sequencing the PDX organoids confirmed transcriptomic genomic similarity primary tumor. PNPCa harbors BRCA2 CHD1 somatic mutations, shows SPOP/FOXA1 -like signature microsatellite...
Bladder Cancer (BLCa) inter-patient heterogeneity is the primary cause of treatment failure, suggesting that patients could benefit from a more personalized approach. Patient-derived organoids (PDOs) have been successfully used as functional model for predicting drug response in different cancers. In our study, we establish PDO cultures BLCa stages and grades. PDOs preserve histological molecular parental tumors, including their multiclonal genetic landscapes, consistently share key...
Triggering receptor expressed on myeloid cells-1 (TREM-1) is a potent amplifier of pro-inflammatory innate immune reactions. While TREM-1-amplified responses likely aid an improved detection and elimination pathogens, excessive production cytokines oxygen radicals can also severely harm the host. Studies addressing pathogenic role TREM-1 during endotoxin-induced shock or microbial sepsis have so far mostly relied administration fusion proteins peptides representing part extracellular domain...
Abstract Although the introduction of novel targeted agents has improved patient outcomes in several human cancers, no such advance been achieved muscle-invasive bladder cancer (MIBC). However, recent sequencing efforts have begun to dissect complex genomic landscape MIBC, revealing distinct molecular subtypes and offering hope for implementation therapies. Her2 (ERBB2) is one most established therapeutic targets breast gastric but targeting not yet demonstrated anti-tumor activity MIBC....
Colorectal cancer (CRC) develops through a multistep process and is modulated by inflammation. However, the inflammatory pathways that support intestinal tumors at different stages remain incompletely understood. Interleukin (IL)-33 signaling plays role in inflammation, yet its contribution to pathogenesis of CRC unknown.Using immunohistochemistry on 713 resected human specimens, we show here IL-33 receptor ST2 are expressed low-grade early-stage CRCs, lesser extent higher-grade more...
Abstract Purpose Uncertain focal bone uptake (UBU) with intensive radiopharmaceutical avidity are frequently observed in patients undergoing [ 18 F]PSMA-1007 PET/CT for the detection of prostate cancer (PC). Such foci can pose diagnostic conundrums and risk incorrect staging. The aim this short communication is to share results PET-guided biopsies such foci. Methods A retrospective analysis revealed 10 who were referred our department biopsy UBU visible a previous PET/CT. F]-PSMA-1007 was...
Invasive fungal infections are associated with high mortality rates, and the lack of efficient treatment options emphasizes an urgency to identify underlying disease mechanisms. We report that disseminated Candida albicans infection is facilitated by interleukin-1 receptor antagonist (IL-1Ra) secreted from macrophages in two temporally spatially distinct waves. Splenic CD169+ release IL-1Ra into bloodstream, impeding early neutrophil recruitment. monocyte-derived tissue further impairs...
Several (pre-) clinical trials are currently investigating the benefit of HER2-targeted therapy in urothelial bladder cancer (UBC). Patients with HER2 amplified UBC could potentially profit from these therapies. However, little is known about histomorphology, protein expression patterns and occurrence alterations gene their tumors. Among 150 metastasizing primary UBC, 13 tumors were identified. Their histopathological features compared matched, non-amplified UBC. was determined by...
Metastases from primary prostate cancers to rare locations, such as the brain, are becoming more common due longer life expectancy resulting improved treatments. Epigenetic dysregulation is a feature of cancer, and distinct DNA methylation profiles have been shown be associated with mutually exclusive SPOP-mutant or TMPRSS2-ERG fusion genetic backgrounds. Using cohort cancer brain metastases (PCBM) 42 patients, matched tumors for 17 we carried out analysis examine epigenetic distinction...
Aims The Oxford Classification E score (endocapillary hypercellularity) predicts renal functional decline in IgA nephropathy (Ig AN ) patients free from steroid/immunosuppressive ( IS therapy, but is poorly reproducible. We hypothesise that endocapillary hypercellularity reflects glomerular inflammation and the presence of CD 68‐positive cells a more robust marker score. Methods results were quantified glomeruli tubulointerstitium biopsies 118 Ig patients, cell counts correlated with...
Improved survival rates for prostate cancer through more effective therapies have also led to an increase in the diagnosis of metastases infrequent locations such as brain. Here we investigate repertoire somatic genetic alterations present brain from 51 patients with (PCBM). We highlight clonal evolution occurring PCBM and demonstrate increased mutational burden, concomitant enrichment homologous recombination deficiency signature compared non-brain metastases. Focusing on known pathogenic...
Epstein-Barr virus (EBV)-associated gastric carcinomas (GC) represent a distinct and well-recognized subtype of cancer with prevalence around 10% all GC. In contrast, EBV has not been reported to play major role in esophageal adenocarcinomas (EAC) the gastro-esophageal junction (GEJ). We report our experiences on collections from two surgical centers discuss current state research this field. Tumor samples 465 primary resected (118 EAC, 73 GEJ 274 GC) were investigated. Presence was...
Aberrant interferon gamma (IFNγ) expression is associated with the pathogenesis of numerous autoimmune- and inflammatory disorders, including bowel diseases (IBD). However, requirement IFNγ for chronic intestinal inflammation remains controversial. The aim this study was thus to investigate role in experimental mouse models innate adaptive immune-cell mediated using genetically microbiota stabilized hosts. While we find that drives acute anti-CD40 colitis model an lymphoid cell...
Response classification after neoadjuvant chemotherapy in muscle-invasive bladder carcinoma is based on the TNM stage at radical cystectomy. We recently showed that histopathologic tumor regression grades (TRGs) add prognostic information to TNM. Our aim was validate significance of TRG cancer a multicenter setting. enrolled 389 patients who underwent cisplatin-based before cystectomy 8 centers between 2010 and 2016. Median follow-up 2.2 years. determined specimens by local pathologists....
Aberrant alternative pre-mRNA splicing (AS) events have been associated with several disorders. However, it is unclear whether deregulated AS directly contributes to disease. Here, we reveal a critical role of the regulator epithelial protein 1 (ESRP1) for intestinal homeostasis and pathogenesis. In mice, reduced ESRP1 function leads impaired barrier integrity, increased susceptibility colitis altered colorectal cancer (CRC) development. Mechanistically, these defects are produced in part by...
Current therapies to treat inflammatory bowel diseases have limited efficacy, significant side effects, and often wane over time. Little is known about the cellular molecular mechanisms operative in process of mucosal healing from colitis. To study such events, we developed a new model reversible colitis which adoptive transfer CD4+CD45RBhi T cells into Helicobacter typhlonius–colonized lymphopenic mice resulted rapid onset colonic inflammation that was through depletion colitogenic cells....
Fabry disease (FD) is a rare X-linked lysosomal storage disorder caused by mutations in the α-galactosidase A gene that obliterate or markedly reduce activity. This results systemic accumulation of its glycosphingolipid substrates body fluids and organs, including kidney. nephropathy can lead to end-stage renal requiring kidney transplantation. Little known about long-term outcomes overall patient survival after transplantation.Here, we report 17 patients (15 male 2 female subjects) who...
BACKGROUND TMPRSS2-ERG gene fusion is the most frequent genetic alteration in prostate cancer. However, information about its distribution lymph node positive cancers and prognostic significance these advanced tumors unknown. METHODS Gene status was determined by fluorescence situ hybridization on a tissue-microarray constructed from 119 hormone-naïve nodal positive, surgically treated containing samples primary corresponding metastases. Data were correlated with various tumor features...
Objective To conduct a central pathology review within randomized clinical trial on salvage radiation therapy ( RT ) in the presence of biochemical recurrence after prostatectomy to assess whether this results changes histopathological prognostic factors, such as Gleason score. Patients and Methods A total 350 patients were specimens from 279 (80%) centrally reviewed by dedicated genitourinary pathologist. score, tumour classification resection margin status reassessed compared with local...
Neuroendocrine serum markers released from prostate cancers have been proposed for monitoring disease and predicting survival. However, neuroendocrine differentiation (NED) in various tissue compartments of metastatic cancer is poorly described its correlation with specific tumor features unclear. NED was determined by Chromogranin A expression on immunostains a microarray 119 nodal positive, hormone treatment-naïve patients who underwent radical prostatectomy extended lymphadenectomy. the...