A5005970124- Bladder and Urothelial Cancer Treatments
- Urological Disorders and Treatments
- Urinary and Genital Oncology Studies
- Prostate Cancer Diagnosis and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Urinary Bladder and Prostate Research
- Prostate Cancer Treatment and Research
- Renal cell carcinoma treatment
- Pelvic floor disorders treatments
- Anesthesia and Pain Management
- Urologic and reproductive health conditions
- Enhanced Recovery After Surgery
- Abdominal Surgery and Complications
- Infectious Disease Case Reports and Treatments
- Renal and Vascular Pathologies
- Hemodynamic Monitoring and Therapy
- Urinary Tract Infections Management
- Kidney Stones and Urolithiasis Treatments
- Ureteral procedures and complications
- Clinical practice guidelines implementation
- Genital Health and Disease
- Pelvic and Acetabular Injuries
- Pediatric Urology and Nephrology Studies
- Organ Donation and Transplantation
- Acute Kidney Injury Research
The Royal Melbourne Hospital
2020-2024
St Thomas' Hospital
2023-2024
University of Bern
2016-2024
The University of Melbourne
2020-2024
University Hospital of Bern
1996-2024
Solothurner Spitäler
2023-2024
University College London
2024
Kantonsschule Olten
2024
Spitalzentrum Centre hospitalier Biel- Bienne
2024
Medical University of Vienna
2023-2024
Abstract Background DNA originating from degenerate tumour cells can be detected in the circulation many types, where it used as a marker of disease burden well to monitor treatment response. Although circulating (ctDNA) measurement has prognostic/predictive value metastatic prostate cancer, its utility localised is unknown. Methods We performed whole-genome sequencing tumour-normal pairs eight patients with clinically undergoing prostatectomy, identifying high confidence genomic...
Response classification after neoadjuvant chemotherapy in muscle-invasive bladder carcinoma is based on the TNM stage at radical cystectomy. We recently showed that histopathologic tumor regression grades (TRGs) add prognostic information to TNM. Our aim was validate significance of TRG cancer a multicenter setting. enrolled 389 patients who underwent cisplatin-based before cystectomy 8 centers between 2010 and 2016. Median follow-up 2.2 years. determined specimens by local pathologists....
To analyse urinary continence in long-term survivors after radical cystectomy (RC) and orthotopic bladder substitution (OBS) according to attempted nerve-sparing (NS) status.We analysed 180 consecutive patients treated at our department between 1985 2007, who underwent RC with OBS, survived ≥10 years RC. We stratified by NS status evaluated outcomes using descriptive statistics Cox proportional hazards regression models. A secondary analysis erectile function as a quality control for NS.The...
Objective To determine the oncological impact of extended pelvic lymph node dissection (ePLND) vs standard PLND (sPLND) during radical cystectomy (RC) in clinically node‐positive (cN+) bladder cancer (BCa). Patients and Methods In this retrospective, multicentre study we included 969 patients who underwent RC with sPLND (internal/external iliac obturator nodes) or ePLND (sPLND plus common presacral without platin‐based peri‐operative chemotherapy for cTany N1‐3 M0 BCa between 1991 2022. We...
The aim of the study was to determine whether forearm muscle strength correlates with sport climbing performance. Three different movements musculature in 25 recreational climbers (performance on sight (os) style mean F7a+, range 6b+ –
Patients with bladder cancer who present hydronephrosis may require drainage of the affected kidney before receiving further treatment. Drainage can be done by retrograde stenting or percutaneously. However, carries risk tumor cell spillage to upper urinary tract. The aim this study was evaluate whether patients are at higher for tract recurrence if has been performed prior radical cystectomy.We retrospectively analyzed records 1,005 consecutive underwent cystectomy our department between...
Orthotopic bladder substitution has been performed on a regular basis for more than 30 years and yet data long-term functional outcomes are still lacking.We evaluated 181 men 19 women who underwent radical cystectomy urinary diversion with ileal orthotopic from 1985 to 2004 had 10 or of followup.Median age at was 63 (IQR 57-69). Median followup 167 months 137-206). Daytime nighttime continence rates peaked 24 postoperatively decreased slightly thereafter during almost 2 decades. At 10, 15 20...
BACKGROUND The use of noradrenaline to enable a restrictive approach intra-operative fluid therapy avoid salt and water overload has gained increasing acceptance. However, concerns have been raised about the impact this on renal function. OBJECTIVES To identify risk factors for acute kidney injury (AKI) in patients undergoing cystectomy with urinary diversion determine whether administration hydration regimens affect early postoperative DESIGN Retrospective observational cohort study....
Introduction: Adjuvant therapy has no defined role for patients with positive surgical margins (PSMs) following radical cystectomy (RC) muscle-invasive bladder cancer (MIBC). The aim of our study was to describe loco-regional recurrence-free survival (LRFS), metastatic-free (MFS), (RFS), cancer-specific (CSS) and overall (OS) identify predictors each endpoint in PSMs RC MIBC. Methods: A collaborative retrospective cohort conducted on 394 who underwent MIBC between January 2000 December 2018...
To assess the long-term safety of nerve-sparing radical prostatectomy (NSRP) in men with high-risk prostate cancer (PCa) by comparing survival outcomes, disease recurrence, need for additional therapy, and perioperative outcomes patients undergoing NSRP to those having non-NSRP.
We performed a urine cytology analysis of pharmacologically induced diuresis for the diagnosis upper tract urothelial carcinoma. To evaluate diagnostic value forced diuresis, an initial cohort 77 consecutive patients with primary carcinoma treated via radical surgery was enrolled. as follow-up procedure, second 1250 who underwent cystectomy bladder cancer selected. In first cohort, sensitivity in invasive, high-grade, low-grade, and concomitant situ 8%, 9%, 0%, 14%, respectively. positive...
Objective To investigate the optimal number of induction chemotherapy cycles needed to achieve a pathological response in patients with clinically lymph node‐positive (cN+) bladder cancer (BCa) who received three or four followed by consolidative radical cystectomy (RC) pelvic node dissection. Patients and Methods We included 388 cisplatin/gemcitabine (dose‐dense) methotrexate, vinblastine, doxorubicin, cisplatin (MVAC), RC for cTanyN1–3M0 BCa. compared complete (pCR = ypT0N0) objective (pOR...